{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:46:39Z","timestamp":1787071599045,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>Marchiafava\u2013Bignami disease (MBD) is a rare neurological disorder characterized by demyelination and necrosis of the corpus callosum, often seen in people with alcohol use disorder, and chronic malnutrition leads to hypovitaminosis (vitamin B1 deficiency), decreased synthesis of neurotransmitters, failure to synthesize glutamine, and decreased myelin synthesis, leading to decreased self-defense against oxidative stress. This case report describes a 32-year-old man with a complex medical history, including alcohol dependence, who presented with neurological symptoms such as altered sensorium and convulsion. Diagnostic imaging via magnetic resonance imaging (MRI) confirmed MBD. Given the patient\u2019s nutritional status, treatment focused on parenteral B vitamin supplementation, particularly thiamine and other B vitamins, which are critical for neurological function. The patient showed no significant improvement in neurological symptoms following vitamin therapy, which highlights a poor prognosis in chronic alcoholism.<\/jats:p>","DOI":"10.4103\/jfmpc.jfmpc_1988_24","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T15:05:00Z","timestamp":1758639900000},"page":"3571-3574","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Marchiafava\u2013Bignami disease: A rare entity in chronic alcoholic with a poor prognosis"],"prefix":"10.4103","volume":"14","author":[{"given":"Parth","family":"Jani","sequence":"first","affiliation":[{"name":"Department of General Medicine, All India Institute of Medical Sciences, Rajkot, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Akholkar","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Government Medical College, Bhavnagar, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devarshi","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Government Medical College, Bhavnagar, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meet","family":"Kachhadia","sequence":"additional","affiliation":[{"name":"Department of Medicine, P.D.U. Medical College, Rajkot, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Government Medical College, Bhavnagar, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"R1-20250924","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1552-6569.2012.00755.x","article-title":"Acute Marchiafava-Bignami disease with extensive diffusion restriction and early recovery:Case report and review of the literature","volume":"24","author":"Wenz","year":"2014","journal-title":"J Neuroimaging"},{"key":"R2-20250924","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1590\/S0103-507X2013000100013","article-title":"Marchiafava-Bignami disease:A rare entity with a poor outcome","volume":"25","author":"Carrilho","year":"2013","journal-title":"Rev Bras Ter 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left-hander","volume":"48","author":"Rosa","year":"1991","journal-title":"Arch Neurol"},{"key":"R9-20250924","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1212\/01.wnl.0000171348.55820.89","article-title":"Marchiafava-Bignami disease:Diffusion-weighted MRI in corpus callosum and cortical lesions","volume":"65","author":"M\u00e9n\u00e9gon","year":"2005","journal-title":"Neurology"},{"key":"R10-20250924","doi-asserted-by":"crossref","first-page":"3922","DOI":"10.1016\/j.radcr.2023.08.032","article-title":"Marchiafava-Bignami disease:Case presentation and radiological imaging","volume":"18","author":"Waack","year":"2023","journal-title":"Radiol Case Rep"},{"key":"R11-20250924","doi-asserted-by":"crossref","first-page":"e9626","DOI":"10.1097\/MD.0000000000009626","article-title":"Clinical and radiological features of Marchiafava-Bignami disease","volume":"97","author":"Dong","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"R12-20250924","first-page":"100174","article-title":"Marchiafava-Bignami disease presenting with psychiatric symptoms:A case report","volume":"2","author":"S\u00f6nmez","year":"2023","journal-title":"Psychiatry Res Case Rep"},{"key":"R13-20250924","doi-asserted-by":"crossref","first-page":"18516","DOI":"10.1038\/s41598-023-45431-6","article-title":"Clinico-radiologic subtypes and therapeutic observation of acute Marchiafava-Bignami disease","volume":"13","author":"Zhang","year":"2023","journal-title":"Sci Rep"}],"container-title":["Journal of Family Medicine and Primary 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