{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:14:31Z","timestamp":1791227671110,"version":"4.1.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The metabolic syndrome (MetS), according to the Adult Treatment Panel III of the National Cholesterol Education Programme, is a collection of metabolic abnormalities that includes one, two, or all three of the following traits: obesity in the abdomen, dyslipidemia, hypertension, fasting blood sugar, or insulin resistance. This study\u2019s aim was to assess the relationship between fasting serum leptin and MetS in elderly adults with T2DM in the Northern Indian population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>The following information was collected from all the participants: (1) anthropometric data, (2) biochemical data, and (3) a lifestyle questionnaire on sociodemographic data, dietary practices, smoking, and alcohol intake to identify their risk factors for diabetes mellitus, CVD, and hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 36 older participants (56.30%) had a history of hypertension, while 29 elderly participants (44.61%) had diabetes mellitus. A total of 32 elderly participants (49.2%) had MetS, and this group had higher serum leptin (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      0.003), body weight (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.019), BMI (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      0.001), waist circumference (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      0.001), CRP (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.021), insulin (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001), and HOMA-IR (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003) values as well as higher percentages of females (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001), and those with type 2 diabetes mellitus (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002) and hypertension (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.039) than those in the non-MetS group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In older persons with T2DM, our study discovered a favorable correlation between serum leptin and MetS. It can act as a standalone indicator of MetS, offering a way to spot populations at risk for associated consequences and enabling early intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_2008_23","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T14:19:55Z","timestamp":1725977995000},"page":"3633-3638","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Exploring the link between leptin levels and metabolic syndrome in elderly Indian patients: Implications for family medicine and primary care practices"],"prefix":"10.4103","volume":"13","author":[{"given":"Arjun Kumar","family":"Singhal","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine and Health Sciences, SGT, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Microbiology, ESIC Medical College and Hospital, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shravan Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Medical Health and Family Welfare, Plibhit, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Busi","family":"Karunanand","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine and Health Sciences, SGT, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gagan","family":"Gunjan","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonu K.","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Consultant Microbiologist, Vimta Labs. 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