{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:10:41Z","timestamp":1788826241762,"version":"build-2803163510"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5]]},"abstract":"\n Context:<\/jats:title>\n A complex dysregulation of glucose homeostasis, Diabetes Mellitus (DM) is an iceberg disease with an ever-rising global (8.5%, 2018) and national prevalence (7.3% - ICMR-INDIAB study, 2017) amidst adults. Besides the micro and macrovascular complications, in virtue of diverse mechanisms that downplay the immune system culminating in an array of infections especially UTIs are commoner in routine diabetic clinics. The spectrum of UTI ranges from asymptomatic bacteriuria (ASB) to serious complications such as emphysematous pyelonephritis, renal abscesses that are encountered frequently among Diabetics than the general population. The risk stratification and varying modalities of presentation of UTIs in diabetics in contrast with non-diabetics are being studied.<\/jats:p>\n <\/jats:sec>\n \n Methods and Material:<\/jats:title>\n A prospective comparative cross-sectional study was conducted in 250 adult consenting participants with equal diabetics and non-diabetics with culture-proven UTI, at the Department of Internal Medicine in a tertiary care hospital of National Capital Territory (NCT) of India, after fulfilling appropriate criteria. Alongside socio-demographic details and vitals parameters, glycaemic status assessment and relevant investigations were done in either group.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Mean age of the participants was 52.18 \u00b1 9.06 with age and gender being reasonably distributed in both the groups. Fever (\n P<\/jats:italic>\n <0.01), dysuria (\n P<\/jats:italic>\n <0.01), urgency (\n P<\/jats:italic>\n <0.01) and urinary frequency (\n P<\/jats:italic>\n <0.01) found frequently among non-diabetics wherein vomiting (\n P<\/jats:italic>\n <0.01) and incontinence (\n P<\/jats:italic>\n <0.01) relatively commoner among diabetics. E. coli, Klebsiella sp., were the most common organisms in both groups with Proteus sp., and Pseudomonas sp., higher among diabetics. Severe infection and Pyelonephritis were frequent (AOR 2.64, 95% CI- 2.01-3.27,\n P<\/jats:italic>\n <0.05) among diabetics. Antimicrobial sensitivity patterns were not significantly different among both groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Primary care physicians are to be acquinted with the possibility that UTI in diabetics could exhibit relatively lesser symptoms or more severe forms of UTI at presentation and less favorable outcomes. Further validation from a larger cohort of diabetics is warranted in terms of symptomatology, diagnostic approach, and sensitivity patterns.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_2017_21","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T07:41:10Z","timestamp":1653464470000},"page":"1902-1906","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":20,"title":["Urinary tract infection and Diabetes Mellitus\u2014Etio-clinical profile and antibiogram"],"prefix":"10.4103","volume":"11","author":[{"given":"Subramani","family":"Jagadeesan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brijendra K.","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranav","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subramanian","family":"Muthathal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-51-20240828","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2991\/jegh.k.191028.001","article-title":"Epidemiology of type 2 diabetes-Global Burden of Disease and forecasted trends","volume":"10","author":"Khan","year":"2020","journal-title":"J Epidemiol Glob Health"},{"key":"R3-51-20240828","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.2147\/DMSO.S262760","article-title":"Bacterial profiles and their associated factors of UTI and detection of extended spectrum beta-lactamase producing Gram-negative uropathogens among patients with diabetes mellitus at Dessie Referral Hospital Northeastern Ethiopia","volume":"13","author":"Alemu","year":"2020","journal-title":"Diabetes Metab Syndr Obes"},{"key":"R4-51-20240828","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/aje\/kwi078","article-title":"Pregnancy outcomes following hospitalization for motor vehicle crashes in Washington State from 1989 to 2001","volume":"161","author":"Schiff","year":"2005","journal-title":"Am J Epidemiol"},{"key":"R5-51-20240828","doi-asserted-by":"crossref","first-page":"510","DOI":"10.2337\/diacare.26.2.510","article-title":"Quantifying the risk of infectious diseases for people with diabetes","volume":"26","author":"Shah","year":"2003","journal-title":"Diabetes Care"},{"key":"R6-51-20240828","doi-asserted-by":"crossref","first-page":"3638","DOI":"10.4103\/jfmpc.jfmpc_71_21","article-title":"Pattern of uropathogens and antibiotic sensitivity in diabetes patients attending to out\u2013Patient department and diabetes clinic of a teaching hospital:A cross-sectional study","volume":"10","author":"Nath","year":"2021","journal-title":"J Fam Med Prim Care"},{"key":"R7-51-20240828","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2337\/diacare.28.1.177","article-title":"Urologic complications of diabetes","volume":"28","author":"Brown","year":"2005","journal-title":"Diabetes Care"},{"key":"R8-51-20240828","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/j.transproceed.2012.12.011","article-title":"Risk factors for recurrent urinary tract infection in kidney transplant recipients","volume":"45","author":"Lim","year":"2013","journal-title":"Transplant Proc"},{"key":"R9-51-20240828","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1007\/BF01643424","article-title":"The epidemiology of urinary tract infection and the concept of significant bacteriuria","volume":"18","author":"Hooton","year":"1990","journal-title":"Infection"},{"key":"R10-51-20240828","doi-asserted-by":"crossref","first-page":"S80","DOI":"10.1016\/S0002-9343(02)01062-8","article-title":"Urinary tract infections in patients with diabetes","volume":"113","author":"Stapleton","year":"2002","journal-title":"Am J Med"},{"key":"R11-51-20240828","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1016\/j.ijantimicag.2007.07.042","article-title":"Urinary tract infections in patients with diabetes mellitus:Epidemiology, pathogenesis and treatment","volume":"31","author":"Geerlings","year":"2008","journal-title":"Int J Antimicrob Agents"},{"key":"R12-51-20240828","first-page":"985","article-title":"Asymptomatic bacteriuria in adults","volume":"74","author":"Colgan","year":"2006","journal-title":"Am Fam Physician"},{"key":"R13-51-20240828","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/clinids\/21.2.316","article-title":"Prevalence of asymptomatic bacteriuria and associated host factors in women with diabetes mellitus. 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