{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:46:39Z","timestamp":1787071599089,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>Conn\u2019s syndrome or primary aldosteronism (PA) due to aldosterone-producing adrenal adenoma (APA) is the most frequent cause of hypokalemia and secondary hypertension. We are reporting a Primary Aldosteronism(PA) case in an indian male, who presented with recurrent lower limb weakness &amp; was admitted twice for management of his symptoms. On evaluating, laboratory reports revealed that his symptoms are due to refractory severe hypokalemia, metabolic alkalosis, raised serum aldosterone levels, and low plasma renin activity. Transtubular potassium gradient (TTKG) was suggestive of ongoing renal potassium loss. Computed Tomography (CT) angiography of adrenal glands during his first admission showed an 8-mm nodule in the right adrenal gland. CT angiography during his second admission with more severe similar complaints revealed an increase in the size of this nodule. The patient was managed with serum potassium correction and surgical intervention. He underwent laparoscopic right adrenalectomy. Following the surgery, the patient serum potassium normalized and he had a good clinical outcome. We suggest clinicians to consider screening for PA and offer surgical intervention wherever necessary in cases with refractory hypokalemia and secondary hypertension.<\/jats:p>","DOI":"10.4103\/jfmpc.jfmpc_2021_24","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T15:04:43Z","timestamp":1758639883000},"page":"3560-3564","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Recurrent hypokalemia induced by primary aldosteronism due to unilateral adrenal adenoma. A case report"],"prefix":"10.4103","volume":"14","author":[{"given":"Srinivas","family":"Nalloor","sequence":"first","affiliation":[{"name":"Department of Nephrology, Apollo BGS Hospital, Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GN","family":"Impana","sequence":"additional","affiliation":[{"name":"Department of Family Medicne, Apollo BGS Hospital, Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benaganahalli S.","family":"Sandeep","sequence":"additional","affiliation":[{"name":"Department of Radiology, Apollo BGS Hospital, Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VN","family":"Ranjitha","sequence":"additional","affiliation":[{"name":"Department of Pathology, Apollo BGS Hospital, Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Raghavendran","sequence":"additional","affiliation":[{"name":"Department of Urology, Apollo BGS Hospital, Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anish","family":"Behl","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Apollo BGS Hospital, Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"R1-20250924","doi-asserted-by":"crossref","first-page":"57","DOI":"10.20452\/pamw.79","article-title":"Micha\u0142Lity\u0144ski\u2014a forgotten author of the first description on primary hyperaldosteronism","volume":"117","author":"Kucharz","year":"2007","journal-title":"Pol Arch Med Wewn"},{"key":"R2-20250924","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/S0140-6736(98)06102-9","article-title":"Mineralocorticoid hypertension","volume":"353","author":"Stewart","year":"1999","journal-title":"Lancet"},{"key":"R3-20250924","doi-asserted-by":"crossref","DOI":"10.4061\/2011\/624691","article-title":"Adrenocortical causes of hypertension","volume":"2011","author":"Moraitis","year":"2011","journal-title":"Int J Hypertens"},{"key":"R4-20250924","doi-asserted-by":"crossref","first-page":"162804","DOI":"10.4061\/2011\/162804","article-title":"Changes in the perceived epidemiology of primary hyperaldosteronism","volume":"2011","author":"Fagugli","year":"2011","journal-title":"Int J Hypertens"},{"key":"R5-20250924","doi-asserted-by":"crossref","first-page":"e114","DOI":"10.3399\/bjgp18X694589","article-title":"Prevalence of primary aldosteronism in primary care:A cross-sectional study","volume":"68","author":"K\u00e4yser","year":"2018","journal-title":"Br J Gen Pract"},{"key":"R6-20250924","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1291\/hypres.27.193","article-title":"Prospective study on the prevalence of secondary hypertension among hypertensive patients visiting a general outpatient clinic in Japan","volume":"27","author":"Omura","year":"2004","journal-title":"Hypertens Res"},{"key":"R7-20250924","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/0002-9343(65)90122-1","article-title":"Conn's syndrome due to adrenal hyperplasia with hypertrophy of zona glomerulosa, relieved by unilateral adrenalectomy","volume":"39","author":"Ross","year":"1965","journal-title":"Am J Med"},{"key":"R8-20250924","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1210\/jc.2003-031337","article-title":"Increased diagnosis of primary aldosteronism, including surgically correctable forms, in centers from five continents","volume":"89","author":"Mulatero","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"R9-20250924","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1210\/jc.2016-1472","article-title":"Study heterogeneity and estimation of prevalence of primary aldosteronism:A systematic review and meta-regression analysis","volume":"101","author":"K\u00e4yser","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"R10-20250924","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1016\/j.jacc.2006.07.059","article-title":"PAPY study investigators. A prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients","volume":"48","author":"Rossi","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"R11-20250924","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/j.jacc.2017.01.052","article-title":"Prevalence and clinical manifestations of primary aldosteronism encountered in primary care practice","volume":"69","author":"Monticone","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"R12-20250924","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1161\/01.HYP.0000040261.30455.B6","article-title":"Hyperaldosteronism among black and white subjects with resistant hypertension","volume":"40","author":"Calhoun","year":"2002","journal-title":"Hypertension"},{"key":"R13-20250924","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/S0140-6736(08)60834-X","article-title":"Prevalence of primary hyperaldosteronism in resistant hypertension:A retrospective observational study","volume":"371","author":"Douma","year":"2008","journal-title":"Lancet"},{"key":"R14-20250924","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1001\/archsurg.141.5.497","article-title":"Primary Hyperaldosteronism:Effect of adrenal vein sampling on surgical outcome","volume":"141","author":"Nwariaku","year":"2006","journal-title":"Arch Surg"},{"issue":"(Suppl 1)","key":"R15-20250924","doi-asserted-by":"crossref","first-page":"S143","DOI":"10.1148\/rg.25si055514","article-title":"Adrenal vein sampling:How to make it quick, easy, and successful","volume":"25","author":"Daunt","year":"2005","journal-title":"Radiographics"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_2021_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:49:16Z","timestamp":1787068156000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_2021_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_2021_24","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2024-12-11","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-11","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}