{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:30:44Z","timestamp":1787841044139,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Dengue fever is a major vector-borne disease worldwide, with a spectrum ranging from mild febrile illness to severe complications such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Identifying clinical and biochemical predictors of mortality is crucial for optimizing management strategies and improving outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To identify clinical and biochemical determinants associated with mortality in hospitalized dengue patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A prospective observational study was conducted at Shyam Shah Medical College, Rewa, over 6 months (July to December 2023). A total of 146 patients with laboratory-confirmed dengue fever were enrolled and monitored. Demographic, clinical, and biochemical parameters were analyzed, and multivariate logistic regression identified independent predictors of mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Mortality was significantly associated with advanced age, abdominal pain, breathlessness, and weakness. Biochemical predictors included thrombocytopenia, elevated transaminases (Serum Glutamic-Oxaloacetic Transaminase Test [SGOT]), bilirubin, and renal markers such as urea and creatinine. Non-survivors also showed a higher prevalence of systemic complications like pleural effusion and ascites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Early identification of risk factors such as advanced age, severe thrombocytopenia, organ dysfunction, and systemic complications can guide timely interventions and reduce dengue-related mortality. These findings are particularly relevant for primary care physicians, who are often the first point of contact in dengue-endemic areas and are key to early diagnosis, risk stratification, and referral for advanced care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_2066_24","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:00:15Z","timestamp":1759006815000},"page":"3856-3860","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Clinical determinants of mortality in dengue fever: A hospital-based study"],"prefix":"10.4103","volume":"14","author":[{"given":"Umesh Pratap","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Medicine, Shyam Shah Medical College and Associated Hospitals, Rewa, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dheerendra K.","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Government Medical College and Associated Hospitals, Satna, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Gangwar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shyam Shah Medical College and Associated Hospitals, Rewa, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramod","family":"Kushwaha","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Shyam Shah Medical College and Associated Hospitals, Rewa, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"R1-20251009","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013","journal-title":"Nature"},{"key":"R2-20251009","doi-asserted-by":"crossref","first-page":"107588","DOI":"10.1016\/j.actatropica.2025.107588","article-title":"Epidemiological and molecular typing of dengue viruses circulating in Jorhat district, Assam, India","volume":"264","author":"Gogoi","year":"2025","journal-title":"Acta Trop"},{"key":"R3-20251009","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0140-6736(14)60572-9","article-title":"Dengue","volume":"385","author":"Guzman","year":"2015","journal-title":"Lancet"},{"key":"R4-20251009","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/S0140-6736(07)61687-0","article-title":"Dengue","volume":"370","author":"Halstead","year":"2007","journal-title":"Lancet"},{"key":"R5-20251009","first-page":"105107","article-title":"Clinical and laboratory determinants of mortality in patients with severe dengue","volume":"152","author":"Sharma","year":"2023","journal-title":"J Clin Virol"},{"key":"R6-20251009","first-page":"820","article-title":"Dengue vaccines: Progress and challenges","volume":"384","author":"Wilder-Smith","year":"2014","journal-title":"Lancet"},{"key":"R7-20251009","first-page":"422","article-title":"Dengue: Clinical and laboratory findings of patients in an endemic area","volume":"28","author":"Souza","year":"2023","journal-title":"Trop Med Int Health"},{"key":"R8-20251009","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1590\/S1020-49892006001100007","article-title":"Dengue in the Americas and Southeast Asia: Do they differ?","volume":"20","author":"Halstead","year":"2006","journal-title":"Rev Panam Salud Publica"},{"key":"R9-20251009","first-page":"35","article-title":"Dengue: A new insight into pathogenesis and therapeutic strategies","volume":"30","author":"Yacoub","year":"2024","journal-title":"Clin Microbiol Infect"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_2066_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:40:08Z","timestamp":1787838008000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_2066_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":9,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_2066_24","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2024-12-19","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-20","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}