{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:23:10Z","timestamp":1787840590107,"version":"build-2784847793"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Erectile dysfunction (ED) is a prevalent condition among male patients with coronary artery disease (CAD), often reflecting underlying vascular problems. Recent studies suggest that serum low-density lipoprotein (LDL) levels, a key factor in atherosclerosis, might serve as an indirect marker of ED in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims &amp; Objectives:<\/jats:title>\n                    <jats:p>The aim of our study is to analyse correlation between serum LDL level and severity of erectile dysfunction. To assess the prevalence of erectile dysfunction in male CAD patients. To evaluate other potential risk factors contributing to erectile dysfunction in male CAD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>From September 2022 to August 2023, 240 CAD patients were analysed for organic ED with the help of IIEF-5 score, and their lipid profile (Cholesterol, Triglyceride, HDL, LDL) were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Mean age in the study group is 47.61\u00b1 7.82 years. The overall prevalence of ED among MALE CAD patients was found out to be 73%, with Mean IIEF-5 score of 16.9 with SD 4.89. LDL cholesterol level had a positive correlation with Severity of ED (p value 4.88\u00d710-16, r=-0.7052, r2=0.49). Mean LDL 95.83mg\/dl with a standard deviation of 31.37. Serum cholesterol level had a positive correlation with Severity of ED (p value= 2.84\u00d710-9). Mean Cholesterol level is 165.5mg\/dl with a SD of 38.66.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Treatment for hyperlipidaemia plays a crucial role in preventing ED, as evidenced by the impact of total cholesterol and LDL in particular on men\u2019s erectile function. This highlights the need for a comprehensive approach to managing ED patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_2073_24","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:01:54Z","timestamp":1761742914000},"page":"4317-4321","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Serum LDL level as an indirect marker of erectile dysfunction in male CAD patients"],"prefix":"10.4103","volume":"14","author":[{"given":"Hariom","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of General Medicine, Shyam Shah Medical College and Associated Hospitals, Rewa, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umesh Pratap","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Shyam Shah Medical College and Associated Hospitals, Rewa, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil K.","family":"Ahuja","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Shyam Shah Medical College and Associated Hospitals, Rewa, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dheerendra Kumar","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Govt. Medical College and Associated Hospitals, Satna, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh","family":"Bendawade","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Shyam Shah Medical College and Associated Hospitals, Rewa, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"R1-20251105","first-page":"e50644","article-title":"Updates in the management of coronary artery disease: A review article","volume":"15","author":"Bansal","year":"2023","journal-title":"Cureus"},{"key":"R2-20251105","first-page":"qeaf014","article-title":"Understanding the erectile dysfunction\u2013cardiovascular disease connection: Clinical and pathophysiological insights","author":"An","year":"2025","journal-title":"Sex Med Rev"},{"key":"R3-20251105","first-page":"1","article-title":"Erectile dysfunction","volume":"2","author":"Yafi","year":"2016","journal-title":"Nat Rev Dis Prim"},{"key":"R4-20251105","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2174\/138945011605150504114041","article-title":"Pathophysiology of erectile dysfunction","volume":"16","author":"Matsui","year":"2015","journal-title":"Curr Drug Targets"},{"key":"R5-20251105","doi-asserted-by":"crossref","first-page":"400","DOI":"10.4103\/aja.aja_73_17","article-title":"Erectile dysfunction is associated with subclinical carotid vascular disease in young men lacking widely-known risk factors","volume":"20","author":"Yao","year":"2018","journal-title":"Asian J Androl"},{"key":"R6-20251105","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2174\/1570161118666200414102556","article-title":"Erectile dysfunction as a cardiovascular risk factor: Time to step up?","volume":"19","author":"Imprialos","year":"2021","journal-title":"Curr Vasc Pharmacol"},{"key":"R7-20251105","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/S0022-5347(05)67900-1","article-title":"Incidence of erectile dysfunction in men 40 to 69 years old: Longitudinal results from the Massachusetts male aging study","volume":"163","author":"Johannes","year":"2000","journal-title":"J Urol"},{"key":"R8-20251105","doi-asserted-by":"crossref","first-page":"307","DOI":"10.4103\/0971-5916.198669","article-title":"Erectile dysfunction: A present day coronary disease risk equivalent","volume":"144","author":"Kapoor","year":"2016","journal-title":"Indian J Med Res"},{"key":"R9-20251105","first-page":"183","article-title":"Endothelial dysfunction: Cardiovascular risk factors, therapy, and outcome","volume":"1","author":"Hadi","year":"2005","journal-title":"Vasc Health Risk Manag"},{"key":"R10-20251105","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.2174\/092986707781058931","article-title":"Dyslipidemia as a risk factor for erectile dysfunction","volume":"14","author":"Vrentzos","year":"2007","journal-title":"Curr Med Chem"},{"key":"R11-20251105","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.3390\/ijms22083850","article-title":"Endothelial dysfunction, inflammation and coronary artery disease: Potential biomarkers and promising therapeutical approaches","volume":"22","author":"Medina-Leyte","year":"2021","journal-title":"Int J Mol Sci"},{"key":"R12-20251105","doi-asserted-by":"crossref","first-page":"461","DOI":"10.4103\/1008-682X.123678","article-title":"The role of statins in erectile dysfunction: A systematic review and meta-analysis","volume":"16","author":"Cai","year":"2014","journal-title":"Asian J Androl"},{"key":"R13-20251105","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/sj.ijir.3900481","article-title":"Reply to 'The sexual health inventory for men (IIEF-5)'by JA Vroege","volume":"11","author":"Cappelleri","year":"1999","journal-title":"Int J Impot Res"},{"key":"R14-20251105","first-page":"6151669","article-title":"Prevalence of erectile dysfunction among patients with coronary artery disease","author":"Mohamed","year":"2024","journal-title":"Andrologia 2024"},{"key":"R15-20251105","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/sj.ijir.3901468","article-title":"Vascular risk factors and erectile dysfunction in a cohort of healthy men","volume":"18","author":"Ponholzer","year":"2006","journal-title":"Int J Impot Res"},{"key":"R16-20251105","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/sj.ijir.3901350","article-title":"The relationship between lipid profile and erectile dysfunction","volume":"17","author":"Nikoobakht","year":"2005","journal-title":"Int J Impot Res"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_2073_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:25:34Z","timestamp":1787837134000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_2073_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_2073_24","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2024-12-20","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-22","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}