{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:31:20Z","timestamp":1787772680052,"version":"build-2784847793"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,6]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n SARS-CoV-2 associated coagulopathy may manifest as hypocoagulability with a propensity for bleeding. Here we report a COVID-19 patient with fatal subdural hematoma (SDH) shortly after thrombendarteriectomy (TEA), and anticoagulation together with anti-thrombotic treatment. A 83-year-old male developed sudden-onset fever triggering a first ever tonic-clonic seizure. His previous history was positive for diabetes, hypertension, hyperlipidemia, aorto-coronary bypass grafting, percutaneous, transluminal coronary angioplasty with stent implantation, peripheral occlusive artery disease with percutaneous, transluminal angioplasty of the left popliteal artery, hypoacusis, and atrial fibrillation. He had undergone TEA 10 days prior to admission because of a non-symptomatic, right-sided 70% common carotid artery stenosis. He was on clopidogrel and edoxaban on admission. He presented with coma, non-reacting, unrounded pupils, stretch synergisms, reduced tendon reflexes, and positive pyramidal signs. Cerebral CT revealed an extensive SDH over the left hemisphere with edema and mass effect and a midline shift to the right. After acute decompression surgery had been declined, the patient expired a few hours after admission. Fatal SDH may occur under clopidogrel and edoxaban during a mild COVID-19 disease after a seizure triggered by fever. Whether hypocoagulation due to COVID-19 increased the bleeding risk and thus contributed to the fatal bleeding remains speculative, but is conceivable.<\/jats:p>","DOI":"10.4103\/jfmpc.jfmpc_2133_21","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T10:17:00Z","timestamp":1656584220000},"page":"3336-3338","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["SARS-CoV-2 triggered seizure complicated by fatal subdural hematoma under edoxaban and clopidogrel"],"prefix":"10.4103","volume":"11","author":[{"given":"Josef","family":"Finsterer","sequence":"first","affiliation":[{"name":"Radiology Department, Klinik Landstrasse, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Korn","sequence":"additional","affiliation":[{"name":"Radiology Department, Klinik Landstrasse, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"B1-20240828","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.21037\/jtd-20-3062","article-title":"Coagulation disorders and thromboembolic disease in COVID-19: Review of current evidence in search of a better approach","volume":"13","author":"Garc\u00eda-Ortega","year":"2021","journal-title":"J Thorax Dis"},{"key":"B2-20240828","first-page":"e13207","article-title":"Multiple arterial thrombosis in a COVID patient with no known comorbidities with mild elevation of D-dimer","volume":"13","author":"Mekheal","year":"2021","journal-title":"Cureus"},{"key":"B3-20240828","doi-asserted-by":"crossref","first-page":"13791","DOI":"10.18632\/aging.103511","article-title":"Pathophysiology of SARS-CoV-2 infection in patients with intracerebral hemorrhage","volume":"12","author":"Dong","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"B4-20240828","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jocn.2020.08.026","article-title":"Intracranial hemorrhage in critically ill patients hospitalized for COVID-19","volume":"81","author":"Fayed","year":"2020","journal-title":"J Clin Neurosci"},{"key":"B5-20240828","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jocn.2020.07.033","article-title":"Olfactory gyrus intracerebral hemorrhage in a patient with COVID-19 infection","volume":"79","author":"Thu","year":"2020","journal-title":"J Clin Neurosci"},{"key":"B6-20240828","doi-asserted-by":"crossref","first-page":"e23862","DOI":"10.1097\/MD.0000000000023862","article-title":"Subarachnoid hemorrhage and COVID-19: Association or coincidence?","volume":"99","author":"Cezar-Junior","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"B7-20240828","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s12028-021-01202-7","article-title":"Intracerebral hemorrhage in COVID-19 patients with pulmonary failure: A propensity score-matched registry study","volume":"34","author":"Lang","year":"2021","journal-title":"Neurocrit Care"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_2133_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:08:43Z","timestamp":1787771323000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_2133_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":7,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_2133_21","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"2021-10-25","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-03","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}