{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T13:47:50Z","timestamp":1785764870913,"version":"3.56.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Colorectal cancer (CRC) is the third most common cancer worldwide and a leading cause of death. The fecal occult blood test (FOBT) is a widely used initial screening test; however, its results can be influenced by multiple factors. This study aimed to evaluate the prevalence of negative FOBT among patients with CRC and possible etiologies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>This case-control study included patients aged 50 years and older who were diagnosed with CRC and underwent FOBT. Risk factors and comorbidities were recorded. FOBT results, Colonoscopy findings, tumor location, and type were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 118 patients diagnosed with CRC, who underwent FOBT were included in this study. Of the 118 patients, 63 were males, and 55 were females, with a mean age of 61.3 years and a mean body mass index of 28.87. The most common comorbidity was hypertension (44.9%). Furthermore, 47.5% of the participants had positive FOBT, and 52.5% had negative FOBT. The most common colonoscopy finding was a mass lesion (49%), which was in the rectum (42.4%). Adenocarcinoma was the most common histopathological diagnosis (81.4%). No significant relationship was observed between FOBT results and other variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>More than half of the CRC cases had negative FOBT despite the distal location and type of the tumor. Screening options should be discussed with patients, and further studies are needed to evaluate noninvasive stool-based tests.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_2252_25","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T20:00:21Z","timestamp":1785182421000},"page":"2224-2229","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["The prevalence of negative fecal occult blood test (FOBT) among colorectal cancer patients in a tertiary care center"],"prefix":"10.4103","volume":"15","author":[{"given":"Layla M.","family":"AlBreacan","sequence":"first","affiliation":[{"name":"Department of Family Medicine and Polyclinics, King Faisal Specialist Hospital and Research Centre Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussam","family":"Jnaid","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Polyclinics, King Faisal Specialist Hospital and Research Centre Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momo","family":"Arai","sequence":"additional","affiliation":[{"name":"College of Medicine, Alfaisal University, Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziad","family":"Helaly","sequence":"additional","affiliation":[{"name":"College of Medicine, Alfaisal University, Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"R1-20260803","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.4103\/jfmpc.jfmpc_16_22","article-title":"The yield of fecal occult blood testing as a screening tool for colon cancer in a primary care setting","volume":"11","author":"Almoneef","year":"2022","journal-title":"J Family Med Prim Care"},{"key":"R2-20260803","first-page":"366","article-title":"The effectiveness of FOBT vs. FIT: A meta-analysis on colorectal cancer screening test","volume":"30","author":"Mousavinezhad","year":"2016","journal-title":"Med J Islam Repub Iran"},{"key":"R3-20260803","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1093\/annonc\/mdq653","article-title":"Alcohol drinking and colorectal cancer risk: An overall and dose-response meta-analysis of published studies","volume":"22","author":"Fedirko","year":"2011","journal-title":"Ann Oncol"},{"key":"R4-20260803","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1001\/jama.2008.839","article-title":"Smoking and colorectal cancer","volume":"300","author":"Botteri","year":"2008","journal-title":"JAMA"},{"key":"R5-20260803","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1093\/aje\/kwu357","article-title":"Weight change and risk of colorectal cancer: a systematic review and meta-analysis","volume":"181","author":"Karahalios","year":"2015","journal-title":"Am J Epidemiol"},{"key":"R6-20260803","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1001\/archinte.166.17.1871","article-title":"Diabetes mellitus and the risk of cancer: Results from a large-scale population-based cohort study in Japan","volume":"166","author":"Inoue","year":"2006","journal-title":"Arch Intern Med"},{"key":"R7-20260803","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1001\/jama.2021.6238","article-title":"Screening for colorectal cancer: US preventive services task force recommendation statement","volume":"325","author":"Davidson","year":"2021","journal-title":"JAMA"},{"key":"R8-20260803","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1136\/gutjnl-2011-301583","article-title":"Random comparison of repeated faecal immunochemical testing at different intervals for population-based colorectal cancer screening","volume":"62","author":"van Roon","year":"2013","journal-title":"Gut"},{"key":"R9-20260803","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1053\/j.gastro.2016.08.053","article-title":"Recommendations on fecal immunochemical testing to screen for colorectal neoplasia: A consensus statement by the US multi-society task force on colorectal cancer","volume":"152","author":"Robertson","year":"2017","journal-title":"Gastroenterology"},{"key":"R11-20260803","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.surge.2020.02.003","article-title":"FIT negative cancers: A right-sided problem? 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