{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:45:53Z","timestamp":1787071553014,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>Vitamin D3 is crucial for various physiological functions in the body, playing a vital role in the maintenance and regulation of the skeletal, immune, muscular, and nervous systems. Excessive supplementation of Vitamin D3, despite its well-documented health benefits, can lead to toxicity. In severe cases, toxicity manifests as hypercalcemia, hypercalciuria, and multi-organ dysfunction. This report presents a case involving a 58-year-old woman with postmenopausal osteoporosis, who developed markedly elevated serum 25(OH)D3 levels of 556 ng\/mL due to uncontrolled cholecalciferol supplementation. Notably, the patient remained asymptomatic, with no abnormalities detected in calcium\u2013phosphate metabolism tests. Vitamin D3 levels normalized spontaneously five months after cessation of supplementation. This case underscores the importance of regular medical oversight when using cholecalciferol, particularly over-the-counter preparations, to monitor calcium\u2013phosphate balance parameters and prevent potential complications.<\/jats:p>","DOI":"10.4103\/jfmpc.jfmpc_225_25","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T11:02:49Z","timestamp":1764327769000},"page":"4907-4909","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Can a 25(OH)D3 level of 556 ng\/mL be asymptomatic? A case report of incorrect supplementation"],"prefix":"10.4103","volume":"14","author":[{"given":"Jakub","family":"Smyk","sequence":"first","affiliation":[{"name":"Ludwik Rydygier Memorial Hospital, Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrycja","family":"Major","sequence":"additional","affiliation":[{"name":"5th Military Clinical Hospital in Krak\u00f3w, Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicja","family":"Kami\u0144ska","sequence":"additional","affiliation":[{"name":"Stefan \u017beromski Specialist Hospital, Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Go\u0142ojuch","sequence":"additional","affiliation":[{"name":"Ludwik Rydygier Memorial Hospital, Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Przemys\u0142aw","family":"Borowy","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, J. Dietl Hospital, Krakow, Poland"},{"name":"Department of Rheumatology and Immunology, Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Pukal","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, J. Dietl Hospital, Krakow, Poland"},{"name":"Department of Rheumatology and Immunology, Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Batko","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, J. Dietl Hospital, Krakow, Poland"},{"name":"Department of Rheumatology and Immunology, Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,11,29]]},"reference":[{"key":"R1-20251211","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1080\/10408363.2022.2070595","article-title":"Vitamin D:Sources, physiological role, biokinetics, deficiency, therapeutic use, toxicity, and overview of analytical methods for detection of vitamin D and its metabolites","volume":"59","author":"Janou\u0161ek","year":"2022","journal-title":"Crit Rev Clin Lab Sci"},{"key":"R2-20251211","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1024\/0300-9831\/a000798","article-title":"Accidental vitamin D3 overdose in a young man","volume":"94","author":"Nekoukar","year":"2024","journal-title":"Int J Vitam Nutr Res"},{"key":"R3-20251211","doi-asserted-by":"crossref","first-page":"550","DOI":"10.3389\/fendo.2018.00550","article-title":"Vitamin D Toxicity-A clinical perspective","volume":"9","author":"Marcinowska-Suchowierska","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"key":"R4-20251211","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s40520-020-01678-x","article-title":"Vitamin D supplementation:Upper limit for safety revisited?","volume":"33","author":"Rizzoli","year":"2021","journal-title":"Aging Clin Exp Res"},{"key":"R5-20251211","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1177\/1352458517738131","article-title":"A review of vitamin D supplementation as disease-modifying therapy","volume":"24","author":"Shoemaker","year":"2018","journal-title":"Mult Scler"},{"key":"R6-20251211","doi-asserted-by":"crossref","first-page":"988","DOI":"10.3390\/nu12040988","article-title":"Evidence that Vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths","volume":"12","author":"Grant","year":"2020","journal-title":"Nutrients"},{"key":"R7-20251211","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ijtb.2023.04.026","article-title":"Effect of adjunct Vitamin D treatment in vitamin D deficient pulmonary tuberculosis patients:A randomized, double blind, active controlled clinical trial","volume":"71","author":"Chandra","year":"2024","journal-title":"Indian J Tuberc"},{"key":"R8-20251211","doi-asserted-by":"crossref","first-page":"695","DOI":"10.3390\/nu15030695","article-title":"Guidelines for preventing and treating Vitamin D deficiency:A 2023 update in Poland","volume":"15","author":"P\u0142udowski","year":"2023","journal-title":"Nutrients"},{"key":"R9-20251211","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1210\/endrev\/bnae009","article-title":"Consensus statement on vitamin D status assessment and supplementation:Whys, Whens, and Hows","volume":"45","author":"Giustina","year":"2024","journal-title":"Endocr Rev"},{"key":"R10-20251211","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/labmed\/lmx077","article-title":"Vitamin D toxicity:A 16-year retrospective study at an academic medical center","volume":"49","author":"Lee","year":"2018","journal-title":"Lab Med"},{"key":"R11-20251211","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/MED.0000000000000371","article-title":"Vitamin D in obesity","volume":"24","author":"Walsh","year":"2017","journal-title":"Curr Opin Endocrinol Diabetes Obes"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_225_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:48:09Z","timestamp":1787068089000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_225_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":11,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_225_25","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-02-06","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-16","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}