{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:38:25Z","timestamp":1787841505580,"version":"build-2784847793"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Laboratory markers like lymphopenia, thrombocytopenia, elevated D-dimer, and C-reactive protein (CRP) predict worse outcomes in coronavirus disease 2019 (COVID-19). However, a comprehensive analysis of hematologic and coagulation parameter alterations based on fever status is lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective study analyzed 300 COVID-19 patients hospitalized from March to December 2020. Demographic, clinical, and laboratory data were extracted from electronic medical records. Patients were stratified into fever (n = 200) and no fever (n = 100) groups. Hematologic, coagulation, and inflammatory markers were compared between groups using appropriate statistical tests. Multivariate regression identified independent predictors of fever.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Fever was associated with leukocytosis, neutrophilia, lymphopenia, thrombocytopenia, elevated CRP, D-dimer, procalcitonin, interleukin-6, neutrophil to lymphocyte ratio (NLR), and ferritin compared to no fever (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). D-dimer (r = 0.42), CRP (r = 0.52), NLR (r = 0.48), and interleukin-6 (r = 0.46) demonstrated the strongest correlation with fever (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). High D-dimer &gt;1000 ng\/mL (adjusted odds ratio 2.7), CRP &gt;100 mg\/L (3.1), lymphopenia &lt;1.0 \u00d7 109\/L (2.8), NLR &gt;4 (2.9), and thrombocytopenia &lt;150 \u00d7 109\/L (2.7) were significant independent predictors of fever status (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.005). These parameters had moderate sensitivity (40\u201360%) and high specificity (74\u201388%) for discriminating febrile patients with AUC of 0.85.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Marked alterations in hematologic, coagulation, and inflammatory markers occur in COVID-19 based on fever. Routine laboratory parameters can facilitate diagnosis and risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_226_24","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T02:03:54Z","timestamp":1721959434000},"page":"3220-3224","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Alterations in hematologic, coagulation, and inflammatory markers based on fever status in hospitalized COVID-19 patients: A retrospective study"],"prefix":"10.4103","volume":"13","author":[{"given":"Bijoya","family":"Chatterjee","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Shri MP Shah Government Medical College, Jamnagar, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikunj","family":"Modi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Shri MP Shah Government Medical College, Jamnagar, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khushi","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Trinity Health Livonia Hospital, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogesh","family":"Murugan","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Shri MP Shah Government Medical College, Jamnagar, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ami","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Shri MP Shah Government Medical College, Jamnagar, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"R2-20240828","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients 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procoagulant pattern of patients with COVID-19 acute respiratory distress syndrome","volume":"18","author":"Ranucci","year":"2020","journal-title":"J Thromb Haemost"},{"key":"R17-20240828","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.thromres.2020.09.026","article-title":"Therapeutic versus prophylactic anticoagulation for severe COVID-19: A randomized phase II clinical trial (HESACOVID)","volume":"196","author":"Lemos","year":"2020","journal-title":"Thromb Res"}],"container-title":["Journal of Family Medicine and Primary 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