{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:05:12Z","timestamp":1788973512363,"version":"build-2803163510"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>Post-modernization has increased infertility globally. Infertility can cause ovarian, breast, and endometrial cancers. Recent studies have shown that a substantial proportion of couples undergoing infertility treatment develop cancer. However, existing studies yielded inconsistent results. Therefore, we conducted a meta-analysis to determine whether infertility increases the risk of ovarian cancer. Our systematic review and meta-analysis intended to identify the association between ovarian cancer and infertility based on the existing research. In accordance with PRISMA guidelines, this review contains studies on infertility and ovarian cancer as an outcome measure among ovarian cancer groups and those not having cancer. Two authors independently retrieved the articles through electronic databases such as PubMed and Scopus. This review includes 25 studies published worldwide between 2001 and 2022. This systematic review has been registered with the International Prospective Registry of Systematic Reviews (PROSPERO) (CRD CRD42021288860). The systematic review included 25 articles, while the meta-analysis included four. In total, data from 84,49,557 participants in 25 studies were extracted (21 cohort studies and 4 case-control studies). The global prevalence of ovarian cancer among women with a history of infertility was 0.5%. The calculated OR of developing ovarian cancer as a result of infertility was 1.35 (95% CI: 0.92\u20131.97). The pooled odds ratio of developing ovarian cancer as a result of infertility drug use was 0.93 (95% CI: 0.94\u20132.46). Pooled effect was shown to be stable and reliable by cumulative meta-analysis. The current meta-analysis showed that women who used infertility drugs had a higher risk of developing OC than those having a history of infertility.<\/jats:p>","DOI":"10.4103\/jfmpc.jfmpc_227_24","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T09:03:37Z","timestamp":1736759017000},"page":"15-21","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Infertility and risk of ovarian cancer: A systematic review and meta analysis"],"prefix":"10.4103","volume":"14","author":[{"given":"Indra","family":"Sambasivam","sequence":"first","affiliation":[{"name":"Research Scholar, School of Public Health, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Gladius","family":"Jennifer","sequence":"additional","affiliation":[{"name":"Associate Professor, School of Public Health, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saravanan","family":"Chinnaiyan","sequence":"additional","affiliation":[{"name":"Research Scholar, School of Public Health, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"R2-20260109","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/humupd\/dmr015","article-title":"Defining infertility--a systematic review of prevalence studies","volume":"17","author":"Gurunath","year":"2011","journal-title":"Hum Reprod Update"},{"key":"R3-20260109","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.cegh.2020.08.008","article-title":"Prevalence and potential determinants of primary infertility in India:Evidence from Indian demographic health survey","volume":"9","author":"Purkayastha","year":"2021","journal-title":"Clin Epidemiol Global Health"},{"key":"R4-20260109","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4103\/0974-1208.170370","article-title":"Trends of male factor infertility, an important cause of infertility:A review of literature","volume":"8","author":"Kumar","year":"2015","journal-title":"J Hum Reprod Sci"},{"key":"R5-20260109","doi-asserted-by":"crossref","first-page":"28","DOI":"10.4103\/0974-1208.178630","article-title":"Prevalence and predictors of infertility-specific stress in women diagnosed with primary infertility:A clinic-based study","volume":"9","author":"Patel","year":"2016","journal-title":"J Hum Reprod Sci"},{"key":"R6-20260109","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.sbspro.2012.01.114","article-title":"Genetic counselling in reproductive disorders","volume":"33","author":"Cozaru","year":"2012","journal-title":"Soc Behav Sci"},{"key":"R7-20260109","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/GCO.0000000000000370","article-title":"Use of fertility medications and cancer risk:A review and update","volume":"29","author":"Kroener","year":"2017","journal-title":"Curr Opin Obstetr Gynecol"},{"key":"R8-20260109","doi-asserted-by":"crossref","first-page":"9","DOI":"10.20892\/j.issn.2095-3941.2016.0084","article-title":"Epidemiology of ovarian cancer:A review","volume":"14","author":"Reid","year":"2017","journal-title":"Cancer Biol Med"},{"key":"R11-20260109","doi-asserted-by":"crossref","first-page":"129","DOI":"10.59566\/IJBS.2013.9129","article-title":"The effect of assisted reproductive technologies on gynecological cancer:Report of our experiences and literature review","volume":"9","author":"Zarchi","year":"2013","journal-title":"Int J Biomed Sci"},{"key":"R12-20260109","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1093\/humrep\/16.7.1372","article-title":"Use of fertility drugs and risk of ovarian cancer","volume":"16","author":"Parazzini","year":"2001","journal-title":"Human Reprod"},{"key":"R13-20260109","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1093\/aje\/kwh315","article-title":"A case-control study of ovarian cancer in relation to infertility and the use of ovulation-inducing drugs","volume":"160","author":"Rossing","year":"2004","journal-title":"Am J Epidemiol"},{"key":"R14-20260109","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1158\/1055-9965.EPI-12-0426","article-title":"Use of fertility drugs and risk of ovarian cancer:Results from a U. 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