{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:27:40Z","timestamp":1787758060257,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,6]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Objective:<\/jats:title>\n To determine the frequency of skeletal dysplasia in children with short stature presenting to the endocrine clinic of a tertiary care hospital.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n This descriptive cross-sectional study was performed in the Outpatient Department of Endocrinology of National Institute of Child Health, Karachi, for 6 months of duration. A total of 200 children coming to endocrine OPD of NICH of either gender, having the age less than 14 years and height more than -2.5 SD below the mean (<3\n rd<\/jats:sup>\n percentile), and growth failure (<4 cm\/yr) were enrolled. A complete general physical examination including height, weight, fronto-occipital circumference (FOC), arm span, and U\/L (upper\/lower) segment ratio (using SI units and SDS) was performed.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Out of 200 children with short stature, skeletal dysplasia was diagnosed in 23 (11.5%) children with the mean age of 4.7 (\u00b13.7) years. Proportion of skeletal dysplasia among short stature was high in females. Out of 75 girls, skeletal dysplasia was diagnosed in 10 (13.3%) girls, while out of 125 boys, skeletal dysplasia was diagnosed in 13 (10.4%) boys, whereas when we see proportion among skeletal dysplasia out of 23 children of skeletal dysplasia, 13 (56.5%) were boys, while 10 (43.5%) were girls.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n In this study, skeletal dysplasia was diagnosed in 11.5% children with short stature with the mean age of 4.7 years. It is concluded that the frequency of skeletal dysplasia in this institute is fairly high.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_2393_21","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T10:17:00Z","timestamp":1656584220000},"page":"3143-3147","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Frequency of skeletal dysplasia in children with short stature presenting to endocrine clinic: An observational study"],"prefix":"10.4103","volume":"11","author":[{"family":"Seema","sequence":"first","affiliation":[{"name":"Department of Pediatrics, National Institute of Child Health, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saira","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dow University Hospital\u2013Ojha Campus, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Nadeem","family":"Ahsan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dow University Hospital\u2013Ojha Campus, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Sohaib","family":"Asghar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Dow University Hospital\u2013Ojha Campus, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"B1-20240828","first-page":"493","article-title":"Etiology of short stature in children","volume":"18","author":"Sultan","year":"2008","journal-title":"J Coll Physicians Surg Pak"},{"key":"B2-20240828","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s12098-007-0183-y","article-title":"Spectrum of severe skeletal dysplasias in North India","volume":"74","author":"Puri","year":"2007","journal-title":"Indian J Pediatr"},{"key":"B3-20240828","doi-asserted-by":"crossref","first-page":"255","DOI":"10.7863\/jum.2003.22.3.255","article-title":"Antenatal detection of skeletal dysplasias","volume":"22","author":"Parilla","year":"2003","journal-title":"J Ultrasound Med"},{"key":"B4-20240828","first-page":"657","article-title":"Skeletal dysplasias in a hospital in southern India","volume":"32","author":"Kulkarni","year":"1995","journal-title":"Indian Pediatr"},{"key":"B5-20240828","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ajmg.a.31483","article-title":"Nosology and classification of genetic skeletal disorders: 2006 revision","volume":"143A","author":"Superti-Furga","year":"2007","journal-title":"Am J Med Genet A"},{"key":"B6-20240828","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1086\/377110","article-title":"Genetic disorders of the skeleton: A developmental approach","volume":"73","author":"Kornak","year":"2003","journal-title":"Am J Hum Genet"},{"key":"B7-20240828","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1002\/ajmg.a.33909","article-title":"Nosology and classification of genetic skeletal disorders: 2010 revision","volume":"155A","author":"Warman","year":"2011","journal-title":"Am J Med Genet A"},{"key":"B8-20240828","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00247-002-0855-8","article-title":"Radiological diagnosis of the constitutional disorders of bone. As easy as A, B, C?","volume":"33","author":"Offiah","year":"2003","journal-title":"Pediatr Radiol"},{"key":"B9-20240828","first-page":"35","article-title":"Etiology of short stature in east azerbaijan, Iran","volume":"19","author":"Shiva","year":"2009","journal-title":"Iran J Pediatr"},{"key":"B10-20240828","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1136\/jmg.27.6.348","article-title":"Consanguinity and its effect on fetal growth and development. A south Indian study","volume":"27","author":"Kulkarni","year":"1990","journal-title":"J Med Genet"},{"key":"B11-20240828","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1046\/j.1440-1754.1998.00308.x","article-title":"An aetiological profile of short stature in the Indian subcontinent","volume":"34","author":"Zargar","year":"1998","journal-title":"J Paediatr Child Health"},{"key":"B12-20240828","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0022-3476(94)70117-2","article-title":"Utah growth study: Growth standards and the prevalence of growth hormone deficiency","volume":"125","author":"Lindsay","year":"1994","journal-title":"J Pediatr"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_2393_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:01:51Z","timestamp":1787756511000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_2393_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_2393_21","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"2021-12-09","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-22","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}