{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:25:50Z","timestamp":1792074350889,"version":"4.4.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Chronic suppurative otitis media (CSOM) is a major cause of hearing disability and morbidity in poor socioeconomic developing countries with prevalence of 4%. Indiscriminate use of antibiotics and poor follow up of patients has resulted in treatment failure, emergence of resistant strains, super infection, intra-cranial and extra-cranial complications in CSOM patients.\n                      <jats:italic toggle=\"yes\">Staphylococcus aureus, P. aeruginosa, Proteus spp. and Klebsiella spp<\/jats:italic>\n                      . are most common organisms causing infection. Knowledge of microbial profile and susceptibility pattern is essential for efficacious treatment of this disorder.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      To determine the clinico-bacteriological profile of CSOM, to analyze the susceptibility pattern of various antibiotics and to evaluate the\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      efficacy of aminoglycosides over fluoroquinolones against the aerobic bacterial isolates from CSOM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We studied 153 clinically suspected CSOM cases from March 2018 to October 2018 in Microbiology and Otorhinolaryngology department. The ear swabs were aerobically cultured and identification of the isolate was done by standard bacteriological methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Safe type CSOM was a major cause of disease. Moderate (35.3%) and mild degree (32.7%) of hearing loss was seen in most of the CSOM cases. The culture positivity rate was 82.4% and the most common isolate was\n                      <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                      (55.8%) followed by\n                      <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                      (27.5%).\n                      <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Enterobacteriaceae<\/jats:italic>\n                      spp. showed high sensitivity to colistin, piperacillin-tazobactam, ceftazidime-tazobactam and good sensitivity for cefepime and amikacin; 33.3%\n                      <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                      isolates were Methicillin-resistant which was sensitive to gentamicin, vancomycin and linezolid.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Knowledge of the spectrum of microorganisms causing ear discharge is important for effective treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_2480_20","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T11:10:32Z","timestamp":1627557032000},"page":"2572-2579","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":23,"title":["Clinico-bacteriological and antibiotic drug resistance profile of chronic suppurative otitis media at a tertiary care hospital in Western Rajasthan"],"prefix":"10.4103","volume":"10","author":[{"given":"Sarika Prabhakar","family":"Kombade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navneet","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sourabha Kumar","family":"Patro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya Lakshmi","family":"Nag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-23-20240828","first-page":"1","article-title":"Mucosal type of chronic suppurative otitis media and the long-term impact on hearing loss","volume":"12","author":"Rajput","year":"2020","journal-title":"Cureus"},{"key":"R2-23-20240828","doi-asserted-by":"crossref","first-page":"358","DOI":"10.5001\/omj.2015.72","article-title":"Prevalence of chronic suppurative otitis media (CSOM) and associated hearing impairment among school-aged children in Yemen","volume":"30","author":"Muftah","year":"2015","journal-title":"Oman Med J"},{"key":"R3-23-20240828","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1007\/s12070-019-01627-9","article-title":"Prevalence of chronic suppurative otitis media among school children residing in Rural Area of Belagavi, South India","volume":"71","author":"Bellad","year":"2019","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"R6-23-20240828","first-page":"1443","article-title":"Clinical vs bacteriological and mycological evaluation in chronic suppurative otitis media","volume":"3","author":"Bhan","year":"2016","journal-title":"Int J Contemporary Med Res"},{"key":"R7-23-20240828","first-page":"27","article-title":"Bacteriological profile and drug sensitivity patterns inchronic suppurative otitis media patientsat J.L.N. 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