{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:04:49Z","timestamp":1787169889516,"version":"build-2736575974"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Posterior urethral valves (PUV) is the commonest obstructive uropathy with varied consequences. Though valve fulguration is the treatment of choice, appropriate bladder management modifies outcome and includes rational use of anticholinergics. Here, we aim to evaluate the effects of oxybutynin on the bladder and urinary tract morphology and function. Concurrently, we document adverse effects encountered, patient compliance, and medication adherence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective study of children below 5 years of age (2012\u20132017) post fulguration and on oxybutynin for at least 6 months. Patient demographics, clinical features, renal ultrasound, micturating cystourethrogram, dimercaptosuccinic acid scan, adverse effects, and pill count for medication adherence were collated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>48 children below the age of 5 years were included, and 12 were excluded either due to the presence of concomitant problems or were not on oxybutynin. Of the 36, four were lost to follow-up and one had died due to an unrelated condition. Thus, a total of 31 children were analyzed. At follow-up, 28\/31 patients were asymptomatic, two had daytime incontinence, and one had recurrent urinary tract infection. All patients except one have preserved renal function tests. On ultrasonography, hydroureteronephrosis worsened in only 1\/25 children and two showed significant post void residues. The resolution of vesicoureteral reflux was noted in almost 50%. 4\/31 renal units had progressive scars. Only two parents defaulted medication. Urodynamic study done in half of these children showed stable bladder pressures except in two.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Oxybutynin therapy following adequate valve fulguration aids upper tracts preservation by stabilizing deranged bladder dynamics. The medication is well tolerated with minimal or no side effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_2554_20","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T13:07:59Z","timestamp":1637327279000},"page":"3706-3711","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Effects of oxybutynin in children with posterior urethral valves post fulguration"],"prefix":"10.4103","volume":"10","author":[{"given":"Joshua Jonathan","family":"Norris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey Pradeep","family":"Raj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tia Teresa","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tijo Thomas","family":"Maleperambil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attibele Mahadevaiah","family":"Shubha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-29-20240828","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0095-5108(03)00060-5","article-title":"Distal urinary obstruction","volume":"30","author":"Kumar","year":"2003","journal-title":"Clin Perinatol"},{"key":"R2-29-20240828","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s00247-007-0495-0","article-title":"Congenital anomalies of the male urethra","volume":"37","author":"Levin","year":"2007","journal-title":"Pediatr Radiol"},{"key":"R3-29-20240828","first-page":"58","article-title":"Contrast-enhanced sonourethrography versus conventional micturition cystourethrography in the assessment of the urethra: Preliminary study","volume":"17","author":"Berrocal","year":"2004","journal-title":"Cir Pediatr"},{"key":"R4-29-20240828","doi-asserted-by":"crossref","first-page":"297","DOI":"10.4103\/jiaps.JIAPS_136_19","article-title":"Insight into posterior urethral valve from our experience: Paradigm appended to abate renal failure","volume":"25","author":"Chatterjee","year":"2020","journal-title":"J Indian Assoc Pediatr Surg"},{"key":"R5-29-20240828","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/S0022-5347(05)65796-5","article-title":"The valve bladder syndrome: 20 years later","volume":"166","author":"Glassberg","year":"2001","journal-title":"J Urol"},{"key":"R6-29-20240828","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4103\/0970-1591.41011","article-title":"Advantages of fulguration of posterior urethral valves by Nd: YAG laser","volume":"17","author":"Gupta","year":"2000","journal-title":"Indian J Urol"},{"key":"R7-29-20240828","first-page":"19","article-title":"Oxybutynin: An overview of the available formulations","volume":"2","author":"McCrery","year":"2006","journal-title":"Ther Clin Risk Manag"},{"key":"R9-29-20240828","first-page":"651","article-title":"Outcome of posterior urethral valve in 64 children","volume":"71","author":"Ezel \u00c7elakil","year":"2019","journal-title":"Single center experience of 22 years. 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The Ditropan XL study group","volume":"95","author":"Versi","year":"2000","journal-title":"Obstet Gynecol"},{"key":"R23-29-20240828","doi-asserted-by":"crossref","first-page":"e14832","DOI":"10.1111\/dth.14832","article-title":"Real-life experience with oral oxybutynin long-term continuous therapy in severe hyperhidrosis and systematic review of the literature","volume":"34","author":"Briatico","year":"2021","journal-title":"Dermatol Ther"},{"key":"R24-29-20240828","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.4103\/jfmpc.jfmpc_254_18","article-title":"Rural health scenario \u2013Role of family medicine: Academy of family physicians of India position paper","volume":"7","author":"Kumar","year":"2018","journal-title":"J Fam Med Prim Care"},{"key":"R25-29-20240828","doi-asserted-by":"crossref","first-page":"111.e1","DOI":"10.1016\/j.jpurol.2020.11.008","article-title":"Urodynamics in posterior urethral valve: Pursuit of prognostication or optimisation","volume":"17","author":"Guha Vaze","year":"2021","journal-title":"J Pediatr Urol"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_2554_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:14:30Z","timestamp":1787166870000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_2554_20"}},"subtitle":["Report in a select cohort of children"],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_2554_20","relation":{},"ISSN":["2249-4863"],"issn-type":[{"value":"2249-4863","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]}}}