{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:27:04Z","timestamp":1786739224265,"version":"build-2736575974"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10]]},"abstract":"\n Introduction:<\/jats:title>\n Neonatal sepsis is an infection in newborns that may be caused by bacteria, fungi, or viruses and has a high death and morbidity rate. The clinical presentation of sepsis may be rather general, making it challenging to make a diagnosis. While blood culture is the most accurate method to diagnose sepsis, it is also time-consuming. Because of this, it is crucial to locate other biomarkers like C-reactive protein (CRP), high sensitive C-reactive protein (hs-CRP), and procalcitonin (PCT) that may aid in early identification.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n To learn about the bacterial composition of suspected cases of neonatal sepsis in a tertiary care hospital in western Uttar Pradesh and how that composition relates to the biomarkers CRP, hs-CRP, and PCT<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n Hundred people who fulfilled the study\u2019s inclusion criteria were included. All neonatal venous blood samples have been obtained after receiving written informed permission from either parent. The conventional method was used to perform the blood culture. The ELISA technique has been used to determine hs-CRP along with serum PCT levels, while the latex agglutination test was utilized for CRP detection.<\/jats:p>\n <\/jats:sec>\n \n Result:<\/jats:title>\n A total of 100 cases were enrolled, 78% presented within 3 days of birth. Blood culture was positive in 33 neonates (33%). There were 17 Gram-positive, 15 Gram-negative, and in all 2 cases with poly bacterial culture. CRP positivity rate was significantly higher in culture positive (57.6%) as compared to culture-negative neonates (25.4%). It was shown that a CRP >6 mg\/l level was sensitive at 57.6% and specific at 74.6%. hs-CRP has a 100% sensitivity and 47.8% specificity. The PCT\u2019s sensitivity was 69.7%, whereas its specificity was 89.6%.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n PCT is more specific for detecting sepsis, but hs-CRP is more sensitive than CRP. The combination of PCT along with hs-CRP has a negative predictive value and high sensitivity compared to other markers. Thus, the most accurate predictors of neonatal sepsis would be a combination of factors.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_269_23","type":"journal-article","created":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T16:12:05Z","timestamp":1696867925000},"page":"2313-2317","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["A study on bacteriological profile in suspected cases of neonatal sepsis and its correlation with various biomarkers in the rural population of a university hospital"],"prefix":"10.4103","volume":"12","author":[{"given":"Khilika","family":"Sethi","sequence":"first","affiliation":[{"name":"Department of Microbiology, Uttar Pradesh University of Medical Sciences, Saifai, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh K.","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Uttar Pradesh University of Medical Sciences, Saifai, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh K.","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Uttar Pradesh University of Medical Sciences, Saifai, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharmendra P.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Uttar Pradesh University of Medical Sciences, Saifai, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sweta","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Uttar Pradesh University of Medical Sciences, Saifai, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,10,11]]},"reference":[{"key":"R1-20260203","first-page":"142","article-title":"Neonatal sepsis","volume":"54","author":"Odabasi","year":"2020","journal-title":"Med Bull Sisli Etfal Hosp"},{"key":"R2-20260203","first-page":"e25539","article-title":"Bacteriological profile and outcome of culture-positive neonatal sepsis in a special newborn care unit setting, Odisha","volume":"14","author":"Mohakud","year":"2022","journal-title":"Cureus"},{"key":"R3-20260203","doi-asserted-by":"crossref","first-page":"e0215683","DOI":"10.1371\/journal.pone.0215683","article-title":"Risk factors of neonatal sepsis in India:A systematic review and meta-analysis","volume":"14","author":"Murthy","year":"2019","journal-title":"PLoS One"},{"key":"R4-20260203","first-page":"509","article-title":"Estimating the diagnostic accuracy of high sensitive C-reactive protein (hs-CRP) in early detection of neonatal sepsis","volume":"33","author":"Lohiya","year":"2021","journal-title":"J Pharm Res Int"},{"key":"R5-20260203","first-page":"157","article-title":"Biomarkers for neonatal sepsis:Recent developments","volume":"4","author":"Mally","year":"2014","journal-title":"Research and Reports in Neonatology"},{"key":"R6-20260203","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1080\/14767058.2017.1322060","article-title":"Biomarkers for diagnosis of neonatal sepsis:A literature review","volume":"31","author":"Sharma","year":"2018","journal-title":"J Matern Fetal Neonatal Med"},{"key":"R7-20260203","doi-asserted-by":"crossref","first-page":"417","DOI":"10.4103\/0972-5229.186226","article-title":"The role of C-reactive protein as a diagnostic predictor of sepsis in a multidisciplinary Intensive Care Unit of a tertiary care center in Nepal","volume":"20","author":"Pradhan","year":"2016","journal-title":"Indian journal of critical care medicine:peer-reviewed, official publication of Indian Society of Critical Care Medicine"},{"key":"R8-20260203","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.pedneo.2018.05.001","article-title":"Validity of biomarkers in screening for neonatal sepsis - A single center -hospital based study","volume":"60","author":"Rashwan","year":"2019","journal-title":"Pediatr Neonatol"},{"key":"R9-20260203","doi-asserted-by":"crossref","first-page":"e572","DOI":"10.1161\/01.CIR.0000148986.52696.07","article-title":"CDC, AHA. 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