{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:32:18Z","timestamp":1786739538379,"version":"build-2736575974"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>There is a significant increase in the number of mucormycosis cases in the setting of the coronavirus disease 2019 (COVID-19) pandemic. This study was undertaken to understand the clinical profile of such patients and the risk factors associated with increased mortality of this already deadly infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A retrospective observational study was conducted by including microbiologically confirmed cases of mucormycosis with the background of COVID-19 infection (COVID-19\u2013associated mucormycosis [CAM]). Data was segregated into those of survivors versus non-survivors and the two groups were analyzed for various risk factors. Early and late CAM were also compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The case fatality rate was 21.73% (5\/23 patients). Case fatality in early CAM was 33.3% versus 9.1% in late CAM. Rhino-orbital-cerebral mucormycosis (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01) and cranial nerve involvement (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0482) were associated with increased mortality. Diabetes and poor glycemic control were the common factors in all patients. Early CAM patients were more likely to have orbital or cerebral involvement (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0065). Patients having chronic liver disease had a higher risk of mortality (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0395). Sequential treatment or concurrent dual drug therapy with a combination of antifungal drugs was independently associated with better survival (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0395). The average duration of treatment with amphotericin-b required for cure by survivors was 29.05 \u00b1 17.05 days. The average duration of treatment with isavuconazole\/posaconazole for survivors was 50.32 \u00b1 25.23 days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Early CAM had a higher case fatality rate. Patients had better recovery rates with sequential or dual antifungal treatment. The raised incidence and mortality in the COVID-19 pandemic is probably related to the COVID-19\u2013induced immunosuppression with associated diabetes and excessive use of steroids.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_291_22","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T05:53:22Z","timestamp":1667973202000},"page":"6107-6114","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Mucormycosis and diabetes in the times of COVID-19: A Mumbai-based observational study"],"prefix":"10.4103","volume":"11","author":[{"given":"Anupa R. A.","family":"Hinduja","sequence":"first","affiliation":[{"name":"General Medicine, Nanavati Max Superspecialtiy Hospital, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul R.","family":"Tambe","sequence":"additional","affiliation":[{"name":"General Medicine, Nanavati Max Superspecialtiy Hospital, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purshottam A.","family":"Giri","sequence":"additional","affiliation":[{"name":"Community Medicine, IIMSR Medical College-Jalna, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suchithra","family":"Sunil","sequence":"additional","affiliation":[{"name":"General Medicine, Nanavati Max Superspecialtiy Hospital, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshad","family":"Limaye","sequence":"additional","affiliation":[{"name":"General Medicine, Nanavati Max Superspecialtiy Hospital, Maharashtra, 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