{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:18:44Z","timestamp":1789103924194,"version":"build-2803163510"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,8,27]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The primary objective of this study was to intervene with vitamin D supplementation in rural-based women with pre-diabetes (impaired fasting glucose or impaired glucose tolerance) to prevent development of type 2 diabetes (T2DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was an open-label randomized placebo-controlled trial conducted in rural women with pre-diabetes and vitamin D deficiency (Clinicaltrials.gov NCT02513888). Women aged 20-60 years with pre-diabetes were selected from rural Haryana (north India) and followed up for two years. A semi-structured questionnaire was used to collect information on socio-demographic and behavioral details, like sun exposure, dietary habits, etc., The intervention group received vitamin D supplementation while control group received lactose granules as placebo. Equal doses of calcium carbonate were given to both the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 132 participants were recruited in the study (58 each in the intervention and control groups). It was observed that there was no statistical significance in the incidence of diabetes in the control group as compared to the intervention group at the end of 2 years (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.701).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Though during the first year there was some delay in development of DM in the intervention group but at the end of two years there was no significant effect of vitamin D supplementation in delaying the incidence of diabetes in these women after two years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration:<\/jats:title>\n                    <jats:p>(Clinicaltrials.gov NCT02513888).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_311_21","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T12:53:08Z","timestamp":1630068788000},"page":"3122-3129","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":14,"title":["A Community Based Randomized Controlled Trial to See the Effect of Vitamin D Supplementation on Development of Diabetes Among Women with Prediabetes Residing in A Rural Community of Northern India"],"prefix":"10.4103","volume":"10","author":[{"given":"Puneet","family":"Misra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashi","family":"Kant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoop","family":"Misra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreya","family":"Jha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Kardam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishakar","family":"Thakur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surya P.","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-63-20240828","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1007\/s00198-009-0954-6","article-title":"Global vitamin D status and determinants of hypovitaminosis D","volume":"20","author":"Mithal","year":"2009","journal-title":"Osteoporos Int"},{"key":"R2-63-20240828","doi-asserted-by":"crossref","first-page":"1080S","DOI":"10.1093\/ajcn\/87.4.1080S","article-title":"Vitamin D deficiency: A worldwide problem with health consequences","volume":"87","author":"Holick","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"R3-63-20240828","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1024\/0300-9831\/a000151","article-title":"Vitamin D, an essential nutrient with versatile functions in nearly all organs","volume":"83","author":"St\u00f6cklin","year":"2013","journal-title":"Int J Vitam Nutr Res"},{"key":"R4-63-20240828","doi-asserted-by":"crossref","first-page":"130","DOI":"10.4161\/derm.23873","article-title":"Vitamin D status and sun exposure in India","volume":"5","author":"Harinarayan","year":"2013","journal-title":"Dermatoendocrinol"},{"key":"R5-63-20240828","doi-asserted-by":"crossref","first-page":"729","DOI":"10.3390\/nu6020729","article-title":"Vitamin D deficiency in India: Prevalence, causalities and interventions","volume":"6","author":"G","year":"2014","journal-title":"Nutrients"},{"key":"R6-63-20240828","doi-asserted-by":"crossref","first-page":"194","DOI":"10.4103\/ijph.IJPH_176_16","article-title":"Vitamin D status of adult females residing in Ballabgarh health and demographic surveillance system: A community-based study","volume":"61","author":"Misra","year":"2017","journal-title":"Indian J Public Health"},{"key":"R7-63-20240828","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1210\/en.2017-00265","article-title":"The role of vitamin D in the prevention of type 2 diabetes: To D or not to D?","volume":"158","author":"Angellotti","year":"2017","journal-title":"Endocrinology"},{"key":"R8-63-20240828","first-page":"1651","article-title":"The effects of vitamin D supplementation on glucose control and insulin resistance in patients with diabetes Type 2: A randomized clinical trial study","volume":"43","author":"Yousefi Rad","year":"2014","journal-title":"Iran J Public Health"},{"key":"R9-63-20240828","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.trsl.2011.05.002","article-title":"Vitamin D3 supplementation improves insulin sensitivity in subjects with impaired fasting glucose?","volume":"158","author":"Nazarian","year":"2011","journal-title":"Transl Res"},{"key":"R10-63-20240828","doi-asserted-by":"crossref","first-page":"e19034","DOI":"10.1097\/MD.0000000000019034","article-title":"Association between vitamin D and prediabetes: A PRISMA-compliant meta-analysis?","volume":"99","author":"Yu","year":"2020","journal-title":"Medicine (Baltimore"},{"key":"R12-63-20240828","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.2337\/dc12-0962","article-title":"Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: A meta-analysis of prospective studies","volume":"36","author":"Song","year":"2013","journal-title":"Diabetes Care"},{"key":"R13-63-20240828","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1093\/ije\/dyt055","article-title":"The Ballabgarh Health and Demographic Surveillance System (CRHSP-AIIMS)","volume":"42","author":"Kant","year":"2013","journal-title":"Int J Epidemiol"},{"key":"R14-63-20240828","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1210\/jc.2015-4013","article-title":"Vitamin D 20,000 IU per week for five years does not prevent progression from prediabetes to diabetes","volume":"101","author":"Jorde","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"R15-63-20240828","doi-asserted-by":"crossref","first-page":"730","DOI":"10.3390\/nu12030730","article-title":"Serum vitamin D concentration\u226575 nmol\/L is related to decreased cardiometabolic and inflammatory biomarkers, metabolic syndrome, and diabetes; and increased cardiorespiratory fitness in us adults","volume":"12","author":"Ganji","year":"2020","journal-title":"Nutrients"},{"key":"R16-63-20240828","doi-asserted-by":"crossref","first-page":"672653","DOI":"10.1155\/2015\/672653","article-title":"Glucose metabolism effects of vitamin D in prediabetes: The VitDmet randomized placebo-controlled supplementation study","volume":"2015","author":"Tuomainen","year":"2015","journal-title":"J Diabetes Res"},{"key":"R17-63-20240828","doi-asserted-by":"crossref","first-page":"387","DOI":"10.4103\/2230-8210.152783","article-title":"Effect of Vitamin D supplementation on glycemic parameters and progression of prediabetes to diabetes: A 1-year, open-label randomized study","volume":"19","author":"Kuchay","year":"2015","journal-title":"Indian J Endocrinol Metab"},{"key":"R18-63-20240828","doi-asserted-by":"crossref","first-page":"486","DOI":"10.3945\/ajcn.111.011684","article-title":"Effects of vitamin D and calcium supplementation on pancreatic \u03b2 cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: The Calcium and Vitamin D for diabetes mellitus (CaDDM) randomized controlled trial","volume":"94","author":"Mitri","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"R19-63-20240828","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/s41598-019-56904-y","article-title":"Vitamin D supplementation in overweight\/obese Asian Indian women with prediabetes reduces glycemic measures and truncal subcutaneous fat: A 78 weeks randomized placebo-controlled trial (PREVENT-WIN Trial)","volume":"10","author":"Bhatt","year":"2020","journal-title":"Sci Rep"},{"key":"R20-63-20240828","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4066\/AMJ.2014.1979","article-title":"The current state of diabetes mellitus in India","volume":"7","author":"Kaveeshwar","year":"2014","journal-title":"Australas Med J"},{"key":"R21-63-20240828","doi-asserted-by":"crossref","first-page":"980","DOI":"10.2337\/dc06-1994","article-title":"The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults","volume":"30","author":"Pittas","year":"2007","journal-title":"Diabetes Care"},{"key":"R22-63-20240828","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/j.1463-1326.2012.01605.x","article-title":"A randomized, placebo-controlled trial of vitamin D supplementation to improve glycaemia in overweight and obese African Americans","volume":"14","author":"Harris","year":"2012","journal-title":"Diabetes Obes Metab"},{"key":"R23-63-20240828","doi-asserted-by":"crossref","first-page":"260","DOI":"10.2337\/dc12-1204","article-title":"High-dose vitamin D supplementation in people with prediabetes and hypovitaminosis D","volume":"36","author":"Davidson","year":"2013","journal-title":"Diabetes Care"},{"key":"R24-63-20240828","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s40795-019-0311-x","article-title":"The effect of vitamin D supplementation on the glycemic control of pre-diabetic Qatari patients in a randomized control trial","volume":"5","author":"Al Thani","year":"2019","journal-title":"BMC Nutr"},{"key":"R26-63-20240828","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1210\/JC.2015-2105","article-title":"Seasonal variability in vitamin D levels no longer detectable in primary hyperparathyroidism","volume":"100","author":"Cong","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"R27-63-20240828","first-page":"535","article-title":"Seasonal variations in serum vitamin D according to age and sex","volume":"3","author":"Heidari","year":"2012","journal-title":"Casp J Intern Med"},{"key":"R28-63-20240828","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1399-3038.2010.01099.x","article-title":"The role of latitude, ultraviolet radiation exposure and vitamin D in childhood asthma and hayfever: An Australian multicenter study","volume":"22","author":"Hughes","year":"2011","journal-title":"Pediatr Allergy Immunol"},{"key":"R29-63-20240828","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1476-511X-11-42","article-title":"Influence of vitamin D supplementation on plasma lipid profiles: A meta-analysis of randomized controlled trials","volume":"11","author":"Wang","year":"2012","journal-title":"Lipids Health Dis"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_311_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:32:24Z","timestamp":1786735944000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_311_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,27]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_311_21","relation":{},"ISSN":["2249-4863"],"issn-type":[{"value":"2249-4863","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8,27]]}}}