{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:32:11Z","timestamp":1786739531999,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The old definitions of fever are based on cross-sectional surveys of the population without analyzing the associated symptomatology as fever is a sign, not symptom. Therefore, a longitudinal follow-up study is the need of hour to analyze associated symptoms with fever.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In a longitudinal study over one year, 196 participants recorded three temperature readings daily, one after waking up, one between 12 and 3 PM, one before sleeping, and filled the symptomatology questionnaire in a thermometry diary.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Per protocol analysis was done for febrile participants (n = 144). Fatigue (50.3%), warmth (47.3%), headache\/head heaviness (47.0%), feeling malaise\/general weakness (46.7%), loss of appetite (46.5%), muscle cramps\/muscle aches (45.6%), chills\/shivering (44.6%), increased sweating (43.0%), nausea (42.5%), irritability (38.9%), increased breathing rate (37.1%), and restlessness\/anxiety\/palpitations (36.5%) were the symptoms maximally seen during the febrile phase. A higher number of associated symptoms are associated with higher temperature readings. Dehydration suggested the numerically highest temperature values (100.86 \u00b1 1.70\u00b0F) but seen in few febrile patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Incorporation of symptom analysis in febrile patients is the need of the hour. Fatigue and warmth are found to be the most prevalent symptoms during febrile phase. Associated symptoms can help in predicting the intensity of fever also.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_360_22","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T05:53:22Z","timestamp":1667973202000},"page":"5990-6000","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["The symptomatology of fever: A step towards qualitative definition of fever"],"prefix":"10.4103","volume":"11","author":[{"given":"Mayank","family":"Kapoor","sequence":"first","affiliation":[{"name":"Department of Internal Medicine (Infectious Disease Division), All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (Infectious Disease Division), All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasan K.","family":"Panda","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (Infectious Disease Division), All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"R2-20260527","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1001\/jama.1992.03490120092034","article-title":"A critical appraisal of 98.6\u00b0F, the upper limit of the normal body temperature, and other legacies of carl reinhold August Wunderlich","volume":"268","author":"Mackowiak","year":"1992","journal-title":"JAMAJ Am Med Assoc"},{"key":"R4-20260527","article-title":"Harrison's Principles of Internal Medicine, 20e","author":"Larry Jameson","year":"2021"},{"key":"R5-20260527","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s13054-016-1375-5","article-title":"The pathophysiological basis and consequences of fever","volume":"20","author":"Walter","year":"2016","journal-title":"Crit Care"},{"key":"R7-20260527","doi-asserted-by":"crossref","first-page":"e49555","DOI":"10.7554\/eLife.49555","article-title":"Decreasing human body temperature in the United States since the industrial revolution","volume":"9","author":"Protsiv","year":"2020","journal-title":"Elife."},{"key":"R8-20260527","first-page":"580","article-title":"Range for normal body temperature in the general population of Pakistan","volume":"58","author":"Adhi","year":"2008","journal-title":"JPMA J Pak Med Assoc"},{"key":"R9-20260527","first-page":"25","article-title":"Comparison of body temperature of elderly with adult in South India","volume":"2","author":"Baby","year":"2016","journal-title":"Mpl J Nurs Health Sci"},{"key":"R10-20260527","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/gerona\/glr001","article-title":"Is older colder or colder older? The association of age with body temperature in 18,630 individuals","volume":"66","author":"Waalen","year":"2011","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"R11-20260527","doi-asserted-by":"crossref","first-page":"811","DOI":"10.4103\/ijccm.IJCCM_324_17","article-title":"Tropical fevers in Indian intensive care units:A prospective multicenter study","volume":"21","author":"Singhi","year":"2017","journal-title":"Indian J Crit Care Med"},{"key":"R12-20260527","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4103\/0972-5229.126074","article-title":"Tropical fevers:Management guidelines","volume":"18","author":"Singhi","year":"2014","journal-title":"Indian J Crit Care Med"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_360_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:29:46Z","timestamp":1786735786000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_360_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":9,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_360_22","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"2022-02-12","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-08","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}