{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:34:57Z","timestamp":1787070897471,"version":"build-2736575974"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose:<\/jats:title>\n                    <jats:p>According to the role of 25-hydroxyvitamin D (25OHD) in glucose homeostasis and immune modulation, vitamin D deficiency may be associated with type 1 diabetes and diabetic ketoacidosis (DKA). Therefore, this study was conducted with the aim of investigation of the relationship between the vitamin D level and severity of diabetic ketoacidosis in new cases of type 1 diabetes in children referred to Hazrat-E-Ali-Asghar Hospital in 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The present study is based on a cross-sectional study. The population studied in this research includes new cases of children with type 1 diabetes referred to Ali Asghar Children\u2019s Hospital in Tehran in 2021. The data analysis was performed using SPSS version 23 software and a significance level of less than 0.05 was considered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In total, 112 people were included in the study. The difference between the three groups of severity of ketoacidosis in blood pH and bicarbonate level was significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). The comparison of serum vitamin D levels in different severity of ketoacidosis showed a significant difference between the three groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.013), which seems to be caused by the significant difference between the severe and mild ketoacidosis groups. There was observed no significant difference between the gender subgroups and different serum vitamin D levels and also different severity of ketoacidosis (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.801) and (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.25).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Based on the findings of our study, there is a significant relationship between vitamin D and the severity of diabetic ketoacidosis in children with type 2 diabetes. We suggest that routine evaluation of vitamin D levels in diabetic patients and prescribing vitamin D supplements to patients with vitamin D deficiency to prevent the risk of diabetic ketoacidosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_375_24","type":"journal-article","created":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T04:02:19Z","timestamp":1731729739000},"page":"4943-4948","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["The investigation of the relationship between vitamin D level and severity of diabetic ketoacidosis in new cases of type 1 diabetes in children referred to Hazrat-E- Ali-Asghar Hospital in 2021"],"prefix":"10.4103","volume":"13","author":[{"given":"Seyed Salaheddin","family":"Nabavi","sequence":"first","affiliation":[{"name":"Department of General Surgery, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahimeh","family":"Soheilipour","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Endocrinology, School of Medicine, Iran University of Medical Sciences, Aliasghar Children Hospital, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motahare Aghajani","family":"Delavar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Iran University of Medical Sciences, Aliasghar Children Hospital, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsa","family":"Javaherchian","sequence":"additional","affiliation":[{"name":"Emergency Medicine Management Research Center, Health Management Research Institute, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pegah","family":"Karimian","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Endocrinology, School of Medicine, Iran University of Medical Sciences, Aliasghar Children Hospital, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabahang","family":"Jafarnejad","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, School of Medicine, Iran University of Medical Sciences, Aliasghar Children Hospital, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamidreza Khoshnezhad","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, School of Medicine, Iran University of Medical Sciences, Aliasghar Children Hospital, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atoosa","family":"Mostafavi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine, Tehran University of Medical Sciences, Shariati Hospital, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyedeh Mahsa Mahmoudinezhad","family":"Dezfouli","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, School of Medicine, Iran University of Medical Sciences, Aliasghar Children Hospital, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayeh","family":"Esmaeilian","sequence":"additional","affiliation":[{"name":"Emergency Medicine Management Research Center, Health Management Research Institute, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeideh","family":"Iranmanesh","sequence":"additional","affiliation":[{"name":"Emergency Medicine Management Research Center, Health Management Research Institute, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"R1-20250129","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/j.1476-4431.2009.00488.x","article-title":"Measurements of microvascular perfusion in healthy anesthetized dogs using orthogonal polarization spectral imaging","volume":"19","author":"Silverstein","year":"2009","journal-title":"J Vet Emerg Crit Care (San Antonio)"},{"key":"R2-20250129","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00592-008-0071-6","article-title":"High prevalence of vitamin D deficiency in type 1 diabetes mellitus and healthy children","volume":"46","author":"Bener","year":"2009","journal-title":"Acta Diabetol"},{"key":"R3-20250129","doi-asserted-by":"crossref","first-page":"h1265","DOI":"10.1136\/bmj.h1265","article-title":"More children showing early signs of serious diabetes complications, audit finds","volume":"350","author":"Kmietowicz","year":"2015","journal-title":"BMJ"},{"key":"R4-20250129","first-page":"59","article-title":"Treatment of diabetic ketoacidosis in children and adolescents","volume":"74","author":"Vanelli","year":"2003","journal-title":"Acta Biomed"},{"key":"R5-20250129","first-page":"e4497","article-title":"Correlation between Vitamin D deficiency and diabetic ketoacidosis","volume":"11","author":"Iqbal","year":"2019","journal-title":"Cureus"},{"key":"R6-20250129","first-page":"290","article-title":"Type 1 diabetes in children:Emergency management","volume":"39","author":"Siafarikas","year":"2010","journal-title":"Aust Fam Physician"},{"key":"R7-20250129","doi-asserted-by":"crossref","first-page":"e1258","DOI":"10.1542\/peds.2007-1105","article-title":"Presence of diabetic ketoacidosis at diagnosis of diabetes mellitus in youth:The search for diabetes in youth study","volume":"121","author":"Rewers","year":"2008","journal-title":"Pediatrics"},{"key":"R8-20250129","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1111\/j.1464-5491.2007.02200.x","article-title":"Diabetic ketoacidosis and cerebral oedema in Sweden\u2014A 2-year paediatric population study","volume":"24","author":"Hanas","year":"2007","journal-title":"Diabet Med"},{"key":"R9-20250129","first-page":"28","article-title":"Assessment of disease severity and risk factors of diabetic ketoacidosis in diabetic patients in Khorramabad Shohada Ashayer hospital","volume":"17","author":"Kavyani","year":"2015","journal-title":"Yafte"},{"key":"R10-20250129","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/sji.12188","article-title":"The role of toll-like receptors and vitamin D in diabetes mellitus type 1\u2013A review","volume":"80","author":"Adamczak","year":"2014","journal-title":"Scand J Immunol"},{"key":"R11-20250129","first-page":"1591","article-title":"Correlation of serum vitamin D level with type 1 diabetes mellitus in children:A meta-analysis","volume":"32","author":"Liu","year":"2015","journal-title":"Nutr Hosp"},{"key":"R12-20250129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/0004-2730000002535","article-title":"Vitamin D and diabetes mellitus:An update 2013","volume":"58","author":"Griz","year":"2014","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"R13-20250129","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1399-5448.2008.00439.x","article-title":"The association between ketoacidosis and 25 (OH)-vitamin D3 levels at presentation in children with type 1 diabetes mellitus","volume":"10","author":"Huynh","year":"2009","journal-title":"Pediatr Diabetes"},{"key":"R14-20250129","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/pedi.12342","article-title":"Low vitamin D level in pediatric patients with new onset type 1 diabetes is common, especially if in ketoacidosis","volume":"17","author":"Al-Zubeidi","year":"2016","journal-title":"Pediatr Diabetes"},{"key":"R15-20250129","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/dme.12200","article-title":"Vitamin D levels during and after resolution of ketoacidosis in children with new onset Type 1 diabetes","volume":"30","author":"Devidayal","year":"2013","journal-title":"Diabet Med"},{"key":"R16-20250129","doi-asserted-by":"crossref","first-page":"523","DOI":"10.54005\/geneltip.1301387","article-title":"Vitamin D level of children with diabetic ketoacidosis in pediatric intensive care unit","volume":"33","author":"Yazici","year":"2023","journal-title":"Genel T\u0131p Dergisi"},{"key":"R17-20250129","first-page":"1","article-title":"Correlation between ketoacidosis and vitamin D levels in children with type 1 diabetes","volume":"20","author":"Gheini","year":"2015","journal-title":"Sci J Kurdistan Univ Med Sci"},{"key":"R18-20250129","doi-asserted-by":"crossref","first-page":"997631","DOI":"10.3389\/fendo.2022.997631","article-title":"Free, bioavailable 25-hydroxyvitamin D levels and their association with diabetic ketoacidosis in children with type 1 diabetes at diagnosis","volume":"13","author":"Choe","year":"2022","journal-title":"Front Endocrinol"},{"key":"R19-20250129","doi-asserted-by":"crossref","first-page":"111596","DOI":"10.1016\/j.mce.2022.111596","article-title":"Vitamin D protects against high glucose-induced pancreatic b-cell dysfunction via AMPK-NLRP3 inflammasome pathway","volume":"547","author":"Wu","year":"2022","journal-title":"Mol Cell Endocrinol"},{"key":"R20-20250129","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.2147\/DMSO.S389609","article-title":"Association between serum vitamin D levels and ketosis episodes in hospitalized patients with newly diagnosed ketosis-prone type 2 diabetes","volume":"15","author":"He","year":"2022","journal-title":"Diabetes Metab Syndr Obes"},{"key":"R21-20250129","doi-asserted-by":"crossref","first-page":"870","DOI":"10.4103\/jfmpc.jfmpc_2411_20","article-title":"Effects of vitamin D on bone density in healthy children:A systematic review","volume":"11","author":"Karimian","year":"2022","journal-title":"J Family Med Prim Care"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_375_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:38:30Z","timestamp":1787067510000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_375_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_375_24","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"2024-03-07","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-03","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}