{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:32:28Z","timestamp":1786739548877,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>Precocious puberty (PP) in pediatric office practice is challenging as the cause varies from benign to malignant conditions. Adrenocortical tumors are rare in childhood and pseudo-precocious puberty is the most common clinical presentation in children. We report a case of a 5-year-old boy who presented with features of abdominal distention and virilization, and his abdominal magnetic resonance imaging (MRI) revealed an adrenal tumor which was confirmed as adrenocortical carcinoma by biopsy. This case report highlights the importance of the awareness among general practioners and pediatricians to rule out adrenocortical tumors while evaluating a child with PP.<\/jats:p>","DOI":"10.4103\/jfmpc.jfmpc_376_22","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T05:53:22Z","timestamp":1667973202000},"page":"6523-6525","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Precocious puberty in a child: A rare cause and review of literature"],"prefix":"10.4103","volume":"11","author":[{"given":"Thulasiraj","family":"Saminathan","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Dhivyalakshmi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latha M.","family":"Sneha","sequence":"additional","affiliation":[{"name":"Department of Division of Pediatric Hematology and Oncology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena D.","family":"Joseph","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"R1-20260527","doi-asserted-by":"crossref","first-page":"625105","DOI":"10.1186\/1687-9856-2010-625105","article-title":"Nonclassic congenital adrenal hyperplasia","volume":"2010","author":"Witchel","year":"2010","journal-title":"Int J Pediatr 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precocious puberty-update 2017","volume":"15","author":"Neyman","year":"2017","journal-title":"Pediatr Endocrinol Rev"},{"key":"R6-20260527","doi-asserted-by":"crossref","first-page":"101273","DOI":"10.1016\/j.beem.2019.04.007","article-title":"Peripheral precocious puberty including congenital adrenal hyperplasia:Causes, consequences, management and outcomes","volume":"33","author":"Haddad","year":"2019","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"R7-20260527","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1590\/S0100-879X2000001000013","article-title":"Adrenocortical tumors in children","volume":"33","author":"Ribeiro","year":"2000","journal-title":"Braz J Med Biol Res"},{"key":"R8-20260527","first-page":"e6440","article-title":"Pseudo-precocious puberty associated with an adrenocortical tumor in a young child","volume":"11","author":"Kafi","year":"2019","journal-title":"Cureus"},{"key":"R9-20260527","first-page":"289","article-title":"Adrenocortical carcinoma presenting with heterosexual pseudoprecocious puberty shortly after birth:A case report and review","volume":"7","author":"Ghazizadeh","year":"2013","journal-title":"Ecancer Med Sci"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_376_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:29:55Z","timestamp":1786735795000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_376_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":9,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_376_22","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"2022-02-14","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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