{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:44:03Z","timestamp":1792464243184,"version":"4.5.0"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disease that affects 0.5\u20131% of the general population and is characterized by a chronic, debilitating, and destructive form of arthritis. Rheumatoid factor (RF) is a frequently used diagnostic test for RA.<\/jats:p>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To evaluate the significance of anti-CCP and RF antibodies in RA diagnosis, to assess diagnostic utility of anti-CCP antibody for RA in relation to RF, and to assess the combined approach (anti-CCP + RF) for early prognosis of RA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>93 patients clinically suspected of RA attending Medicine OPD at ESIC (Employees State Insurance Corporation) Hospital, Bangalore, were included in the study. About 5 ml of blood was collected aseptically from clinically suspected RA patients. Serum was separated and tested for RA factor and anti-CCP antibodies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Analysis:<\/jats:title>\n                    <jats:p>Sensitivity, specificity, and positive predictive value were calculated using 2 \u00d7 2 table, with fixed row margins (a + b) and column margins (c + d); conventionally, disease is on top and test is on the side.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>RA factor is positive in 12 RA patients, anti-CCP patients in 24 RA patients, combined RA and anti-CCP positive in 8 patients, sensitivity of RA factor 33.3%, anti-CCP 66.6%, and RA + Anti CCP 33.3% Specificity of RA factor 17.54%, Anti CCP 1.75%, and RA + Anti CCP 7% positive Predictive value of RA Factor 54.5%, Anti CCP 100%, and RA + Anti CCP 66.6%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Anti-CCP antibodies have a high sensitivity and positive predictive value, making them an excellent tool for differentiating RA from other forms of arthritis. Because of its high specificity, RF is a useful screening marker for RA diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_391_25","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:00:15Z","timestamp":1759006815000},"page":"3873-3876","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Use of anti-cyclic citrullinated peptide antibodies and rheumatoid factor in diagnosis of rheumatoid arthritis in a tertiary care hospital"],"prefix":"10.4103","volume":"14","author":[{"given":"Prathiba","family":"Mahadevaiah","sequence":"first","affiliation":[{"name":"Department of Microbiology, ESICMC and PGIMSR, Rajajinagar, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raksha","family":"Yoganand","sequence":"additional","affiliation":[{"name":"Department of Microbiology, ESICMC and PGIMSR, Rajajinagar, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi G.","family":"Siddappa","sequence":"additional","affiliation":[{"name":"Department of Microbiology, ESICMC and PGIMSR, Rajajinagar, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pareyam","family":"Pooja","sequence":"additional","affiliation":[{"name":"Department of Microbiology, ESICMC and PGIMSR, Rajajinagar, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"R2-20251009","doi-asserted-by":"crossref","first-page":"94","DOI":"10.4103\/2277-5706.241258","article-title":"Metabolic syndrome in patients with rheumatoid arthritis:Clinical implications","volume":"2","author":"Kumar","year":"2013","journal-title":"J Clin Sci Res"},{"key":"R3-20251009","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s12016-007-8023-4","article-title":"The role of anti-cyclic cytrullinate antibodies testing in rheumatoid arthritis","volume":"34","author":"Alessandri","year":"2008","journal-title":"Clin Rev Allergy Immunol"},{"key":"R4-20251009","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1136\/ard.62.9.870","article-title":"Clinical utility of the anti-CCP assay in patients with rheumatic diseases","volume":"62","author":"Lee","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"R5-20251009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1573397052954208","article-title":"Anti-CCP Antibody detection facilities early diagnosis and prognosis of Rheumatoid Arthritis","volume":"1","author":"Pruijn","year":"2005","journal-title":"Curr Rheumatol Rev"},{"key":"R6-20251009","first-page":"48","article-title":"An epidemiological study on clinically suspected Rheumatoid Arthritis patients of eastern Uttar Pradesh","volume":"2","author":"Ahmad","year":"2014","journal-title":"India Scholars World-IRMJCR"},{"key":"R7-20251009","first-page":"689","article-title":"Role of anti cyclic citrullanated peptide antibodies in erosive disease in patients with Rheumatoid arthritis","volume":"124","author":"Shankar","year":"2006","journal-title":"Indian J Med Res"},{"key":"R8-20251009","first-page":"137","article-title":"A comparative study in the Diagnosis of Rheumatoid Arthritis in a Tertiary Care Hospital","volume":"3","author":"Dedwal","year":"2017","journal-title":"Int J Med Microbiol Trop Dis"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_391_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:48:54Z","timestamp":1787068134000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_391_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":7,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_391_25","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-03-07","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-22","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}