{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:52:02Z","timestamp":1790628722362,"version":"4.1.0"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Rh immunoprophylaxis has helped to decrease the prevalence of Rh D associated Haemolytic disease of New-born and Foetus. 50 different RBC antigens have been reported to be associated with HDFN. The current incidence of alloimmunization due to non-RhD antibodies in Western countries is 0.28\u20130.33%. A study on 707 neonates showed antigen-positivity and evidence of HDFN in 37%, with the most severe with DAT-positive anti-Rh antibodies, C, D, e, E. Early detection, monitoring, and planned interventions would help to prevent severe HDFN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The Study included 370 pregnant women attending the antenatal clinic of our hospital and excluded those with a history of transfusion, haemolytic disease, intrauterine bleeding or intrauterine death. Irregular antibodies were checked by the Indirect Coombs Test (ICT) using ID Diacell I-II-III, Diamed, Switzerland. Specific antibody identification was performed using ID Diapanel, Diamed, Switzerland.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Analysis:<\/jats:title>\n                    <jats:p>Statistical analysis was done using IBM SPSS Statistics 20.0. Pearson\u2019s Chi-square test was applied. Odds ratio and their 95% CI were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Red cell antibody screening was positive in 3.5% (13). Antibodies identified as anti-D (30.8%), anti-c (15.4%), anti-C + D (15.4%), anti-K (15.4%), anti-Le b + Jka (7.7%), anti-E (7.7%), and anti-c + Jka (7.7%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The maternal alloimmunization prevalence was 3.5%. The potential for severe HDFN associated with antibodies such as anti-K, anti-E, and anti-c necessitates vigilant monitoring at the primary care level.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_407_25","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T15:04:34Z","timestamp":1758639874000},"page":"3538-3541","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence of alloantibodies among antenatal women attending a teaching hospital in central Kerala"],"prefix":"10.4103","volume":"14","author":[{"given":"Rose Mary","family":"Jacob Vatakencherry","sequence":"first","affiliation":[{"name":"Department of Physiology, Amrita School of Medicine, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"John","sequence":"additional","affiliation":[{"name":"Department of Physiology, Amrita School of Medicine, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veena","family":"Shenoy","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Amrita School of Medicine, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Saraswathy","sequence":"additional","affiliation":[{"name":"Department of Physiology, Amrita School of Medicine, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, 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