{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:26:38Z","timestamp":1787757998348,"version":"build-2784847793"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Most studies have focussed on short and medium-term survival in dilated cardiomyopathy (DCM) patients. We aimed to study the profile and changes in left ventricular ejection fraction (LVEF) of nonischemic DCM patients who survived more than 10 years on medical management alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a retrospective analysis of patients in the nonischemic DCM cohort recruited from April 2003 to January 2007 with LVEF \u226440%. All patients who survived at least 10 years from the initial DCM diagnosis and were on medical therapy alone were included in the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Forty of 127 (31.5%) patients survived over 10 years. Mean follow-up duration was 145.48 \u00b1 16.8 months. Baseline left ventricular (LVEF) was 30.01 \u00b1 7.89%. Of these, 26 (65%) patients showed recovery of LVEF. Eight (30.8%) of these had a relapse following initial recovery. 14 patients (35%) did not show improvement in LVEF. Multivariate analysis showed that only variable associated with sustained recovery of LVEF was shorter QRS duration with a mean QRS duration of 95.2 \u00b1 11.3 ms versus 117.4 \u00b1 22.6 ms in the two groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>31. 5% of patients with nonischemic DCM survived more than 10 years with medical therapy alone. Almost two-thirds of these long-term survivors showed recovery of LVEF. Narrow QRS duration predicted sustained recovery of LVEF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_434_21","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T10:17:00Z","timestamp":1656584220000},"page":"2389-2392","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Profile of nonischemic dilated cardiomyopathy patients with long-term survival \u226510 years on medical therapy alone"],"prefix":"10.4103","volume":"11","author":[{"given":"Inderjeet S.","family":"Monga","sequence":"first","affiliation":[{"name":"Department of Cardiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parminder","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Bahl","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"B1-20240828","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1056\/NEJM198706043162301","article-title":"Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS)","volume":"316","year":"1987","journal-title":"N Engl J Med"},{"key":"B2-20240828","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1056\/NEJM199108013250501","article-title":"Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure","volume":"325","author":"Yusuf","year":"1991","journal-title":"N Engl J Med"},{"key":"B3-20240828","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM199909023411001","article-title":"The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators","volume":"341","author":"Pitt","year":"1999","journal-title":"N Engl J Med"},{"key":"B4-20240828","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1016\/S0140-6736(99)04440-2","article-title":"Effect of metoprolol CR\/XL in chronic heart failure:Metoprolol CR\/XL randomised intervention trial in congestive heart failure (MERIT-HF)","volume":"353","year":"1999","journal-title":"Lancet"},{"key":"B5-20240828","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1161\/01.CIR.0000035653.72855.BF","article-title":"Effect of carvedilol on the morbidity of patients with severe chronic heart failure:Results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study","volume":"106","author":"Packer","year":"2002","journal-title":"Circulation"},{"key":"B6-20240828","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1056\/NEJMoa1409077","article-title":"Angiotensin-neprilysin inhibition versus enalapril in heart failure","volume":"371","author":"McMurray","year":"2014","journal-title":"N Engl J Med"},{"key":"B7-20240828","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1056\/NEJMoa1911303","article-title":"Dapagliflozin in patients with heart failure and reduced ejection fraction","volume":"381","author":"McMurray","year":"2019","journal-title":"N Engl J Med"},{"key":"B8-20240828","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1056\/NEJMoa1009540","article-title":"Cardiac-resynchronization therapy for mild-to-moderate heart failure","volume":"363","author":"Tang","year":"2010","journal-title":"N Engl J Med"},{"key":"B9-20240828","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jacc.2020.05.075","article-title":"Heart failure with recovered left ventricular ejection fraction:JACC scientific expert panel","volume":"76","author":"Wilcox","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"B10-20240828","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.cardfail.2011.03.005","article-title":"Heart failure with recovered ejection fraction:A distinct clinical entity","volume":"17","author":"Punnoose","year":"2011","journal-title":"J Card Fail"},{"key":"B11-20240828","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.ihj.2020.07.016","article-title":"Long-term outcomes of non-ischemic dilated cardiomyopathy patients with left ventricular ejection fraction\u226419% on medical therapy","volume":"72","author":"Agstam","year":"2020","journal-title":"Indian Heart J"},{"key":"B12-20240828","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.amjcard.2014.06.021","article-title":"Frequency of recovery and relapse in patients with nonischemic dilated cardiomyopathy on guideline-directed medical therapy","volume":"114","author":"Gupta","year":"2014","journal-title":"Am J Cardiol"},{"key":"B13-20240828","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0140-6736(18)32484-X","article-title":"Withdrawal of pharmacological treatment for heart failure in patients with recovered dilated cardiomyopathy (TRED-HF):An open-label, pilot, randomised trial","volume":"393","author":"Halliday","year":"2019","journal-title":"Lancet"},{"key":"B14-20240828","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1161\/CIRCULATIONAHA.113.006855","article-title":"Heart failure with recovered ejection fraction:clinical description, biomarkers, and outcomes","volume":"129","author":"Basuray","year":"2014","journal-title":"Circulation"},{"key":"B15-20240828","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S1388-9842(00)00150-1","article-title":"Frequency, prognosis and predictors of improvement of systolic left ventricular function in patients with 'classical'clinical diagnosis of idiopathic dilated cardiomyopathy","volume":"3","author":"Cicoira","year":"2001","journal-title":"Eur J Heart Fail"},{"key":"B16-20240828","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ahj.2007.08.010","article-title":"Recovery of normal ventricular function in patients with dilated cardiomyopathy:predictors of an increasingly prevalent clinical event","volume":"155","author":"Binkley","year":"2008","journal-title":"Am Heart J"},{"key":"B17-20240828","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ijcard.2016.07.090","article-title":"Left ventricular size as a predictor of outcome in patients of non-ischemic dilated cardiomyopathy with severe left ventricular systolic dysfunction","volume":"221","author":"Gupta","year":"2016","journal-title":"Int J Cardiol"},{"key":"B18-20240828","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1186\/s12872-021-02124-0","article-title":"Temporal trends in outcome and patient characteristics in dilated cardiomyopathy, data from the Swedish Heart Failure Registry 2003-2015","volume":"21","author":"Sj\u00f6land","year":"2021","journal-title":"BMC Cardiovasc Disord"},{"key":"B19-20240828","first-page":"100821","article-title":"Effects and clinical implications of sacubitril\/valsartan on left ventricular reverse remodeling in patients affected by chronic heart failure:A 24-month follow-up","volume":"35","author":"Paolini","year":"2021","journal-title":"Int J Cardiol Heart Vasc"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_434_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:01:22Z","timestamp":1787756482000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_434_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_434_21","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"2021-03-04","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-05","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}