{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T13:47:36Z","timestamp":1785764856442,"version":"3.56.0"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    Varicella-zoster virus (VZV) meningitis has been reported during treatment with amenamevir (AMNV). Although case reports have raised concerns about its ability to prevent central nervous system (CNS) complications, cerebrospinal fluid (CSF) penetration has not been evaluated. We report the first case of VZV meningitis with measured CSF AMNV concentration. An 80-year-old man developed altered consciousness and dysarthria on day 7 of AMNV therapy for thoracic herpes zoster. The CSF AMNV concentration on admission was 0.086 \u00b5mol\/L (41.3 ng\/mL), measured 20\u201324 h after the last dose, within the reported\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    half-maximal effective concentration (EC\n                    <jats:sub>50<\/jats:sub>\n                    ) range for VZV (0.055\u20130.10 \u00b5mol\/L) in Japan; however, the clinical relevance of this comparison remains uncertain. The patient\u2019s condition improved rapidly after initiation of acyclovir therapy. This case provides the first direct evidence that AMNV reaches the CSF. However, whether CSF exposure is sufficient to prevent CNS complications or attenuate disease severity remains unclear.\n                  <\/jats:p>","DOI":"10.4103\/jfmpc.jfmpc_473_26","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T20:00:22Z","timestamp":1785182422000},"page":"2338-2340","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Varicella-zoster virus meningitis during amenamevir therapy with measured cerebrospinal fluid drug concentration: A case report"],"prefix":"10.4103","volume":"15","author":[{"given":"Rina","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Department of Critical Care and Emergency Medicine, National Hospital Organization Yokohama Medical Center, Yokohama City, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Horiuchi","sequence":"additional","affiliation":[{"name":"Department of Critical Care and Emergency Medicine, National Hospital Organization Yokohama Medical Center, Yokohama City, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of Critical Care and Emergency Medicine, National Hospital Organization Yokohama Medical Center, Yokohama City, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Critical Care and Emergency Medicine, National Hospital Organization Yokohama Medical Center, Yokohama City, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Furuya","sequence":"additional","affiliation":[{"name":"Department of Critical Care and Emergency Medicine, National Hospital Organization Yokohama Medical Center, Yokohama City, Kanagawa, 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amenamevir (ASP2151): Phase 1, open-label, single-dose, parallel-group studies","volume":"34","author":"Kusawake","year":"2017","journal-title":"Adv Ther"},{"key":"R10-20260803","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.cmi.2024.12.008","article-title":"Optimization of antiviral dosing in Herpesviridae encephalitis: A promising approach to improve outcome?","volume":"31","author":"Nau","year":"2025","journal-title":"Clin Microbiol Infect"},{"key":"R11-20260803","article-title":"Amenalief Tab. 200 mg Review Report 2017"}],"container-title":["Journal of Family Medicine and Primary 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