{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:32:36Z","timestamp":1786739556635,"version":"build-2736575974"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>\n                    Since March 2021, cases with unusual clots, particularly cerebral venous sinus thrombosis and splanchnic vein thrombosis, have been reported worldwide following adenoviral vector-based coronavirus disease 2019 (COVID-19) vaccination. This entity has been termed vaccine-induced thrombotic thrombocytopenia (VITT). We report a 23-year-old healthy female who developed seizures, altered sensorium, and left hemiparesis, 20 days after receiving the first dose of adenoviral vector-based COVID-19 vaccine \u201cCovishield\n                    <jats:sup>\u2122<\/jats:sup>\n                    .\u201d The patient had transient thrombocytopenia. The D-dimer level was 2460 ng\/mL. Magnetic resonance imaging (MRI) demonstrated occlusion of M2 segment of the middle cerebral artery and cerebral infarction. Platelet factor-4 antibodies level was normal. Treatment with aspirin and antiepileptic drugs resulted in a remarkable recovery. This is the first Indian case report of ischemic stroke and transient thrombocytopenia following SARS-CoV-2 ChAdOx1 nCoV-19 vaccination. Our case had clinical features consistent with the diagnosis of probable VITT. Familiarity with VITT is crucial because timely treatment with non-heparin anticoagulants and intravenous immunoglobulin improves the outcome.\n                  <\/jats:p>","DOI":"10.4103\/jfmpc.jfmpc_476_22","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T05:53:22Z","timestamp":1667973202000},"page":"6556-6559","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["A case of ischemic stroke and transient thrombocytopenia in a young female following adenoviral vector-based COVID-19 vaccination: Was the association incidental or causal?"],"prefix":"10.4103","volume":"11","author":[{"given":"Shweta","family":"Pandey","sequence":"first","affiliation":[{"name":"Department of Neurology, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra Kumar","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Neurology, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Neurology, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hardeep S.","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Neurology, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Neurology, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"R1-20260527"},{"key":"R5-20260527","doi-asserted-by":"crossref","first-page":"102941","DOI":"10.1016\/j.autrev.2021.102941","article-title":"Autoimmunity roots of the thrombotic events after COVID-19 vaccination","volume":"20","author":"Elrashdy","year":"2021","journal-title":"Autoimmun Rev"},{"key":"R6-20260527","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.pcad.2021.05.001","article-title":"Covid-19 vaccine- induced thrombosis and thrombocytopenia-a commentary on an important and practical clinical dilemma","volume":"67","author":"Gupta","year":"2021","journal-title":"Prog Cardiovasc Dis"},{"key":"R7-20260527","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/d41586-021-02291-2","article-title":"COVID vaccines and blood clots:What researchers know so far","volume":"596","author":"Ledford","year":"2021","journal-title":"Nature"},{"key":"R8-20260527","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1056\/NEJMoa2109908","article-title":"Clinical features of vaccine-induced immune thrombocytopenia and thrombosis","volume":"385","author":"Pavord","year":"2021","journal-title":"N Engl J Med"},{"key":"R9-20260527","doi-asserted-by":"crossref","first-page":"102184","DOI":"10.1016\/j.dsx.2021.06.021","article-title":"Anti-PF4 antibody negative cerebral venous sinus thrombosis without thrombocytopenia following immunization with COVID-19 vaccine in an elderly non-comorbid Indian male, managed with conventional heparin-warfarin based anticoagulation","volume":"15","author":"Dutta","year":"2021","journal-title":"Diabetes Metab Syndr"},{"key":"R10-20260527","first-page":"1","article-title":"Australian New Zealand approach to diagnosis and management of vaccine induced immune thrombosis and thrombocytopenia","volume":"10","author":"Chen","year":"2021","journal-title":"Med J Aust"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_476_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:29:57Z","timestamp":1786735797000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_476_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":7,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_476_22","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"2022-02-26","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-21","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}