{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:34:40Z","timestamp":1793424880021,"version":"4.5.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Anti-thyroid antibodies not only cause thyroid dysfunction but have independent adverse outcomes in the fetus and mother during pregnancy and after birth. Chronic lymphocytic thyroiditis as a presentation of immune system deregulation may be associated with a generalized activation of the immune system at the fetus\u2013maternal unit, the placenta. This interference could be associated with pregnancy morbidities in m o t h e r a n d fetus. This study was done to find out the frequency of autoimmune thyroid disease and its effect on maternal and fetal outcomes in a tertiary care facility in Jharkhand.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>This is an Observational Prospective Study done during an 18-month period on 254 pregnant women in their second trimester who came to the antenatal clinic (ANC) clinic with singleton pregnancy at RIMS Ranchi.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result:<\/jats:title>\n                    <jats:p>\n                      222 (87.4%) out of the 254 pregnant women had anti- TPO antibodies less than 35 IU\/ml. Anti-thyroid peroxidase (anti-TPO) antibody positivity with values greater than 35 IU\/ml was found in 32 patients (12.6%). Anti-TPO antibody mean value was 22.54 \u00b1 19.67 IU\/ml. Among the 222 individuals who tested negative for the anti-TPO antibody, 7 (3.3%) had miscarriages, 182 (88.3%) gave birth vaginally, and 33 (14.9%) underwent a cesarean section. Of the 32 individuals who tested positive for the anti-TPO antibody, 2 (6.3%) had miscarriages, 24 (75.0%) had vaginal deliveries, and 6 (18.8%) had cesarean sections. Using the Chi-square test, a\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value of 0.549 was calculated, indicating statistical insignificance (Pearson Chi-square test value = 0.200\n                      <jats:sup>a<\/jats:sup>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Anti-TPO antibody positivity was significantly related to miscarriage and anemia. Other complications like preterm delivery, pre-eclampsia, and low birth weight were higher in anti-TPO antibody-positive patients as compared to anti-TPO antibody-negative patients. However, these findings were not statistically significant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_485_24","type":"journal-article","created":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T04:01:48Z","timestamp":1731729708000},"page":"4916-4925","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["A study of autoimmune thyroid disease in pregnant women and its effect on fetal and maternal outcome"],"prefix":"10.4103","volume":"13","author":[{"given":"Shreyasi C.","family":"Ekka","sequence":"first","affiliation":[{"name":"Department of Physiology, Sheikh Bhikhari Medical College, Hazaribag, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mani Bhushan K.","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Physiology, RIMS, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Physiology, Sheikh Bhikhari Medical College, Hazaribag, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"R1-20250129","doi-asserted-by":"crossref","first-page":"250","DOI":"10.22270\/jddt.v13i12.6133","article-title":"A Review on Hashimoto's thyroiditis","volume":"13","author":"Geetha","year":"2023","journal-title":"J Drug Deliv Ther"},{"key":"R2-20250129","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.bpobgyn.2019.03.003","article-title":"Autoimmunity in obstetrics and autoimmune diseases in pregnancy","volume":"60","author":"De","year":"2019","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"R3-20250129","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.placenta.2014.02.004","article-title":"Potentiating maternal immune tolerance in pregnancy:A new challenging role for regulatory T cells","volume":"35","author":"Alijotas-Reig","year":"2014","journal-title":"Placenta"},{"key":"R4-20250129","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1001\/jama.1957.02980130015004","article-title":"Chronic thyroiditis and autoimmunization","volume":"164","author":"Witebsky","year":"1957","journal-title":"J Am Med Assoc"},{"key":"R5-20250129","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1089\/thy.1999.9.631","article-title":"What happens to the normal thyroid during pregnancy?","volume":"9","author":"Glinoer","year":"1999","journal-title":"Thyroid"},{"key":"R6-20250129","first-page":"4","article-title":"Establishment of reference range for maternal thyroid function of Gujarati women","volume":"12","author":"Patel","year":"2019","journal-title":"Med Int J of Biochemistry"},{"key":"R7-20250129","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1177\/0192623313482205","article-title":"The placenta in toxicology. 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