{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:27:28Z","timestamp":1786728448892,"version":"build-2736575974"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>While visco-supplementation is being used for the treatment of knee osteoarthritis (OA), the published reports vary widely in benefits afforded by this treatment. It was therefore proposed to assess the objective parameters along with subjective outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>Our study assessed the radiological and clinical efficacy of single-dose high-molecular-weight intra-articular hyaluronic acid (HMW-IAHA) injection in knee OA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings and Design:<\/jats:title>\n                    <jats:p>This interventional cohort study was conducted in a calculated sample size of 44 patients with knee OA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Visual analog scale (VAS) and knee OA and outcome score (KOOS) were used for clinical assessment, and whole organ magnetic resonance imaging score (WORMS) for radiological assessment. The subjects were given a single dose of HMW-IAHA injection, 90 mg\/3 ml, and were assessed on day 0 and day 90.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Analysis:<\/jats:title>\n                    <jats:p>Statistical Package for Social Sciences (SPSS) software was used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>At the day 90 follow-up, there was an improvement in mean \u00b1 standard deviation values of VAS score (day 0: 8.53 \u00b1 0.81, day 90: 5.97 \u00b1 0.87), KOOS score (day 0: 27.33 \u00b1 15.18, day 90: 57.26 \u00b1 14.26), and the cartilage signal and morphology in the medial femorotibial joint (day 0: 11.02 \u00b1 6.26 and day 90: 10.91 \u00b1 6.22) and patellofemoral joint (day 0: 10.35 \u00b1 4.36 and day 90: 10.28 \u00b1 4.39) compartments. There was a decrease in synovitis score from 2.3 \u00b1 1.61 to 1.3 \u00b1 1.3 in the medial femorotibial joint compartment and total WORMS score (day 0: 66.57 \u00b1 36.06, day 90: 65.14 \u00b1 35.62).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>A single dose of intra-articular injection with high-molecular-weight hyaluronic acid produces improvement in the clinical symptoms and quality of life as well as is effective in maintaining the articular cartilage integrity and reducing synovial inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_486_23","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T13:03:50Z","timestamp":1693227830000},"page":"1692-1696","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Clinical and radiological efficacy of single-dose intra-articular high-molecular-weight hyaluronic acid in knee osteoarthritis"],"prefix":"10.4103","volume":"12","author":[{"given":"Anjana","family":"Babu","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chethan","family":"Channaveera","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, New Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh K.","family":"Mittal","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Subharti Medical College, Meerut, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepthi S.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,8,29]]},"reference":[{"key":"R1-20240828","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.joca.2014.01.003","article-title":"OARSI guidelines for the non-surgical management of knee osteoarthritis","volume":"22","author":"McAlindon","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"key":"R2-20240828","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/ar623","article-title":"Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: Mechanisms of action","volume":"5","author":"Moreland","year":"2003","journal-title":"Arthritis Res Ther"},{"key":"R3-20240828","first-page":"59","article-title":"Rheological properties of synovial fluids","volume":"44","author":"Fam","year":"2007","journal-title":"Biorheology"},{"key":"R4-20240828","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.joca.2019.06.011","article-title":"OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis","volume":"27","author":"Bannuru","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"key":"R5-20240828","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/art.1780290816","article-title":"Development of criteria for the classification and reporting of osteoarthritis. 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