{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:17:51Z","timestamp":1787847471620,"version":"build-2784847793"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:p>Recently coronavirus outbreak which started in Wuhan, China, has caused international concern that has affected more than 29 lakh people worldwide and with no vaccine or specific antiviral drugs present as well as oblivious testing of carriers who are generally asymptomatic, the use of general health intervention techniques are failing to comply. As compared to other epidemics like severe acute respiratory syndrome-coronavirus (SARS-CoV) and the Middle-East respiratory syndrome (MERS-CoV), coronavirus (also named as COVID-19) exhibit mild symptoms in the majority of cases. But in the case of a vulnerable population, it can prove to be life-threatening. Relying on proper barrier technique, use of chest computed tomography scans, managing co-morbid conditions of susceptible patients, identifying the pattern of disease spread as well as the use of polymerase chain reaction to assess the specificity of cases will eventually prove to be efficacious since most of the positive cases are asymptomatic at the beginning which poses a challenge to the primary health care physicians. The development of vaccines will also take some time so it is better to know about COVID-19 better and also follow quarantine restrictions properly till then. In this review, we try to put forward all the relevant studies which have been published by the end of March 2020 so as to summarize the natural history, diagnosis as well as treatment strategies for eradicating COVID-19, which will help in managing this pandemic.<\/jats:p>","DOI":"10.4103\/jfmpc.jfmpc_496_20","type":"journal-article","created":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T10:08:40Z","timestamp":1595758120000},"page":"3200-3204","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Novel coronavirus- A comprehensive review"],"prefix":"10.4103","volume":"9","author":[{"given":"Aparna M.","family":"Nair","sequence":"first","affiliation":[{"name":"Department of Periodontics, PMS College of Dental Science and Research, Trivandrum, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PH","family":"Shilpa","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, AIMST University, Bedong, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Shekhar","sequence":"additional","affiliation":[{"name":"Government Dental Surgeon, PHC Sampatchak, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul V. C.","family":"Tiwari","sequence":"additional","affiliation":[{"name":"CLOVE Dental and OMNI Hospitals, Visakhapatnam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izaz","family":"Shaik","sequence":"additional","affiliation":[{"name":"Rutgers School of Dental Medicine, Newark, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhargavi","family":"Dasari","sequence":"additional","affiliation":[{"name":"Rutgers School of Dental Medicine, Newark, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heena","family":"Tiwari","sequence":"additional","affiliation":[{"name":"PGDHHM, Government Dental Surgeon, Kondagaon, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,7]]},"reference":[{"key":"R1-20260813","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14744\/ejmo.2020.12220","article-title":"2019 novel coronavirus (COVID- 19) outbreak: A review of the current literature","volume":"4","author":"Sahin","year":"2020","journal-title":"EJMO"},{"key":"R2-20260813","doi-asserted-by":"crossref","DOI":"10.1007\/s11606-020-05762-w","article-title":"Review of the clinical characteristics of coronavirus disease 2019 (COVID-19)","author":"Jiang","year":"2020","journal-title":"J Gen Intern Med"},{"key":"R3-20260813","first-page":"200490","article-title":"Coronavirus disease 2019 (COVID-19): A perspective from China","author":"Zu","year":"2020","journal-title":"Radiology"},{"key":"R4-20260813","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1056\/NEJMe2002387","article-title":"Covid-19 \u2014 Navigating the uncharted","volume":"382","author":"Fauci","year":"2020","journal-title":"N Engl J Med"},{"key":"R5-20260813","article-title":"Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China","author":"Dong","year":"2020","journal-title":"Pediatrics"},{"key":"R6-20260813","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.2214\/AJR.20.22969","article-title":"Radiology perspective of coronavirus disease 2019 (COVID-19): Lessons from severe acute respiratory syndrome and Middle East respiratory syndrome","volume":"214","author":"Hosseiny","year":"2020","journal-title":"AJR Am J Roentgenol"},{"key":"R7-20260813","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.molmed.2020.02.008","article-title":"COVID-19: Epidemiology, evolution, and cross-disciplinary perspectives","volume":"26","author":"Sun","year":"2020","journal-title":"Trends Mol Med"},{"key":"R8-20260813","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0140-6736(20)30251-8","article-title":"Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding","volume":"395","author":"Lu","year":"2020","journal-title":"Lancet"},{"key":"R9-20260813","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"A pneumonia outbreak associated with a new coronavirus of probable bat origin","volume":"579","author":"Zhou","year":"2020","journal-title":"Nature"},{"key":"R10-20260813","doi-asserted-by":"crossref","first-page":"E135","DOI":"10.3390\/v12020135","article-title":"Return of the Coronavirus: 2019-nCoV","volume":"12","author":"Gralinski","year":"2020","journal-title":"Viruses"},{"key":"R11-20260813","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1056\/NEJMc2001272","article-title":"Importation and human-to-human transmission of a novel coronavirus in Vietnam","volume":"382","author":"Phan","year":"2020","journal-title":"N Engl J Med"},{"key":"R12-20260813","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1016\/S0140-6736(20)30313-5","article-title":"2019-nCoV transmission through the ocular surface must not be ignored","volume":"395","author":"Lu","year":"2020","journal-title":"Lancet"},{"key":"R13-20260813","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"R14-20260813","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0140-6736(20)30211-7","article-title":"Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study","volume":"395","author":"Chen","year":"2020","journal-title":"Lancet"},{"key":"R15-20260813","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1148\/radiol.2020200230","article-title":"CT imaging features of 2019 novel coronavirus (2019-nCoV)","volume":"295","author":"Chung","year":"2020","journal-title":"Radiology"},{"key":"R16-20260813","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0140-6736(20)30154-9","article-title":"A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster","volume":"395","author":"Chan","year":"2020","journal-title":"Lancet"},{"key":"R18-20260813","doi-asserted-by":"crossref","DOI":"10.1093\/cid\/ciaa237","article-title":"In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","author":"Yao","year":"2020","journal-title":"Clin Infect Dis"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_496_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:19:31Z","timestamp":1787843971000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_496_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":17,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_496_20","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"2020-03-29","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-28","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}