{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:20:41Z","timestamp":1787772041075,"version":"build-2784847793"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,2]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Introduction:<\/jats:title>\n Drug-induced lichen planus is a cutaneous adverse effect that manifests as a systemic eruption of flat-topped, erythematous, or violaceous papules resembling lichen planus on the trunk and extremities. Although antitubercular therapy has been linked to cutaneous hypersensitivity reactions, the literature on such cases is scarce. Here, we present a case to contribute to this field, reporting on its presentation and management, and reviewing previous case studies.<\/jats:p>\n <\/jats:sec>\n \n Case Report:<\/jats:title>\n Our patient, a 63-year-old male, presented with black pigmented patches on the skin, having been diagnosed with pulmonary tuberculosis and on antitubercular therapy for the past two months. A diagnosis of ATT-induced lichen planus was made, and all ATT was stopped. The patient was treated with antihistamines, apremilast, tacrolimus, and corticosteroids, and rechallenge of each drug was performed consecutively. No new lesions appeared after rechallenge with isoniazid and rifampicin. However, ethambutol was not reintroduced due to strong suspicion, by exclusion, that it was the offending agent, whereas on rechallenge with isoniazid and rifampicin, the patient\u2019s skin lesions gradually improved with eventual resolution of hyperpigmentation.<\/jats:p>\n <\/jats:sec>\n \n Discussion and Conclusion:<\/jats:title>\n Lichenoid drug eruptions are characterized by type IV hypersensitivity reactions, and rechallenge is required to ensure safer treatment since the risk of disseminated and multi-drug-resistant tuberculosis increases with the cessation of antitubercular therapy.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_499_23","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T11:16:46Z","timestamp":1709637406000},"page":"438-443","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Antitubercular drug-induced lichen planus: A case study with a mini literature review"],"prefix":"10.4103","volume":"13","author":[{"given":"Sanjana C.","family":"Shanmukhappa","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Unity Hospital, Rochester, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winny","family":"John","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, KLE College of Pharmacy, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineeta","family":"Kevalramani","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, KLE College of Pharmacy, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srivatsa","family":"Lokeshwaran","sequence":"additional","affiliation":[{"name":"Department of Interventional Pulmonology, Aster CMI Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shireen","family":"Furtado","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Aster CMI Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh","family":"Nosenoor","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, KLE College of Pharmacy, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,3,6]]},"reference":[{"key":"R1-20240828","doi-asserted-by":"crossref","first-page":"205","DOI":"10.2147\/JAA.S251046","article-title":"Lichenoid reaction caused by antihistamines and corticosteroids","volume":"13","author":"Suryana","year":"2020","journal-title":"J Asthma Allergy"},{"key":"R2-20240828","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4103\/ijdd.ijdd_65_20","article-title":"A case series of generalized lichenoid drug eruption due to anti-tubercular drugs: Treated with immunosuppressant's while continuing anti-tubercular therapy","volume":"8","author":"Pathave","year":"2022","journal-title":"Indian J Drugs Dermatol"},{"key":"R3-20240828","first-page":"92","article-title":"Case report isoniazid induced generalized lichenoid drug eruption: An unusual offender","volume":"13","author":"Singh","year":"2020","journal-title":"Indian J Phar Pract"},{"key":"R4-20240828","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1136\/postgradmedj-2019-137435","article-title":"Rifampicin-induced lichenoid drug eruption","volume":"96","author":"Bhanja","year":"2020","journal-title":"Postgrad Med J"},{"key":"R6-20240828","doi-asserted-by":"crossref","first-page":"281","DOI":"10.4168\/aair.2017.9.3.281","article-title":"A Case of cycloserine-induced lichenoid drug eruption supported by the lymphocyte transformation test","volume":"9","author":"Kim","year":"2017","journal-title":"Allergy Asthma Immunol Res"},{"key":"R7-20240828","doi-asserted-by":"crossref","first-page":"95","DOI":"10.5021\/ad.1989.1.2.95","article-title":"Lichenoid drug eruption due to Ethambutol","volume":"1","author":"Seo","year":"1989","journal-title":"Ann Dermatol"},{"key":"R8-20240828","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2013-202346","article-title":"Rifampicin-induced lichenoid eruptions","author":"Shahul","year":"2014","journal-title":"BMJ Case Rep 2014"},{"key":"R9-20240828","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1097\/DAD.0b013e3182919e3a","article-title":"Lichenoid eruption associated with antituberculous drug;An unusual oral and follicular involvement","volume":"36","author":"Byun","year":"2014","journal-title":"Am J Dermatopathol"},{"key":"R10-20240828","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0190-9622(93)70176-T","article-title":"Lichenoid drug eruptions","volume":"29","author":"Halevy","year":"1993","journal-title":"J Am Acad Dermatol"},{"key":"R11-20240828","first-page":"53","article-title":"Diagnosis and treatment of lichen planus","volume":"84","author":"Usatine","year":"2011","journal-title":"Am Fam Physician"},{"key":"R13-20240828","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/jdv.18879","article-title":"Cutaneous lichenoid drug eruptions: A narrative review evaluating demographics, clinical features and culprit medications","volume":"37","author":"Maul","year":"2023","journal-title":"J Eur Acad Dermatol Venereol"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_499_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:25:21Z","timestamp":1787768721000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_499_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_499_23","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"2023-03-20","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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