{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:38:32Z","timestamp":1786649912365,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>\n                    <jats:italic toggle=\"yes\">Streptococcus intermedius<\/jats:italic>\n                    , a gram-positive, beta-hemolytic, catalase-negative member of the\n                    <jats:italic toggle=\"yes\">Streptococcus milleri<\/jats:italic>\n                    group, is a commensal organism within the human body that is known for its propensity to cause severe bacterial infections. This case report presents two distinct cases involving culture-positive\n                    <jats:italic toggle=\"yes\">S. intermedius<\/jats:italic>\n                    infections. The first case involves a 53-year-old man diagnosed with new liver, lung, and brain lesions in the setting of suspected renal cell carcinoma. In the second case, an 84-year-old woman was found to have\n                    <jats:italic toggle=\"yes\">S. intermedius<\/jats:italic>\n                    bacteremia with concurrent culture-positive liver abscesses. These cases illustrate the intricate nature of\n                    <jats:italic toggle=\"yes\">S. intermedius<\/jats:italic>\n                    infections, which may manifest with a diverse spectrum of clinically significant systemic symptoms. Presently, there are no standardized protocols for screening, and subsequently managing,\n                    <jats:italic toggle=\"yes\">S. intermedius<\/jats:italic>\n                    infections. Since\n                    <jats:italic toggle=\"yes\">S. intermedius<\/jats:italic>\n                    has the potential to mimic other infections or pathological conditions, it warrants space on a differential until a negative culture or PCR assay is obtained.\n                  <\/jats:p>","DOI":"10.4103\/jfmpc.jfmpc_723_24","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T09:02:34Z","timestamp":1736758954000},"page":"470-472","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Navigating a stealthy invader: Insights from two different Streptococcus intermedius cases"],"prefix":"10.4103","volume":"14","author":[{"given":"Erica Casey","family":"Anders","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Edward Via College of Osteopathic Medicine, Carolinas Campus, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Edward Via College of Osteopathic Medicine, Carolinas Campus, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"R1-20260109","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1086\/514658","article-title":"Clinical significance of bacteremia involving the \u201cStreptococcus milleri\u201dgroup: 51 cases and review","volume":"27","author":"Bert","year":"1998","journal-title":"Clin Infect Dis"},{"key":"R2-20260109","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1086\/320163","article-title":"Streptococcus intermedius, Streptococcus constellatus, and Streptococcus anginosus (\u201cStreptococcus milleri Group\u201d) are of different clinical importance and are not equally associated with abscess","volume":"32","author":"Clarridge","year":"2001","journal-title":"Clin Infect Dis"},{"key":"R3-20260109","doi-asserted-by":"crossref","first-page":"826","DOI":"10.3389\/fmicb.2020.00826","article-title":"From normal flora to brain abscesses: A review of Streptococcus intermedius","volume":"11","author":"Issa","year":"2020","journal-title":"Front Microbiol"},{"key":"R4-20260109","first-page":"e26786","article-title":"Streptococcus intermedius bacteremia and pyogenic liver abscess in a patient with no risk factors","volume":"14","author":"Kurkowski","year":"2022","journal-title":"Cureus"},{"key":"R5-20260109","doi-asserted-by":"crossref","first-page":"956677","DOI":"10.3389\/fmicb.2022.956677","article-title":"The clinical view on streptococcus anginosus group \u2013opportunistic pathogens coming out of hiding","volume":"13","author":"Pilarczyk-Zurek","year":"2022","journal-title":"Front Microbiol"},{"key":"R6-20260109","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s10096-012-1782-8","article-title":"The role of Streptococcus intermedius in brain abscess","volume":"32","author":"Mishra","year":"2013","journal-title":"Eur J Clin Microbiol Infect Dise"},{"key":"R7-20260109","doi-asserted-by":"crossref","first-page":"e6813","DOI":"10.1002\/ccr3.6813","article-title":"Acase report of multiple abscesses caused by Streptococcus intermedius","volume":"11","author":"Reyes","year":"2023","journal-title":"Clin Case Rep"},{"key":"R8-20260109","first-page":"932","article-title":"Role of hyaluronidase in Streptococcus intermedius biofilm","volume":"154","author":"Pecharki","year":"2008","journal-title":"Microbiology (N Y)"},{"key":"R9-20260109","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1128\/iai.64.8.3093-3100.1996","article-title":"intermedilysin, a novel cytotoxin specific for human cells, secreted by streptococcus intermedius UNS46 isolated from a human liver abscess","volume":"64","author":"Nagamune","year":"1996","journal-title":"Infect Immun"},{"key":"R10-20260109","doi-asserted-by":"crossref","first-page":"100689","DOI":"10.1016\/j.adro.2021.100689","article-title":"Streptococcus intermedius: A mimicker of brain metastases and a potential pitfall for radiation oncologists","volume":"6","author":"Casper","year":"2021","journal-title":"Adv Radiat Oncol"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_723_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:59:50Z","timestamp":1786647590000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_723_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_723_24","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-05-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-10","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}