{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:21:36Z","timestamp":1789586496689,"version":"build-2803163510"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>Coronavirus disease 2019 (COVID-19) and tuberculosis (TB), are presently the major infectious diseases imposing a consequential public health threat and their coinfection has a significant impact on the outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To evaluate the clinical features and outcomes of COVID-19-TB coinfected cases compared to solely COVID-19-infected cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings and Design:<\/jats:title>\n                    <jats:p>A retrospective observational study was conducted between August 1, 2020, to February 28, 2022, at a tertiary care hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>In this case-control study, an equal number of gender-age-matched COVID-19 and TB coinfected patients and COVID-19 cases without TB were included using simple random sampling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Analysis Used:<\/jats:title>\n                    <jats:p>\n                      The data was analyzed using SPSS v 26. Categorical variables were compared using the Chi-square test, and an independent\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test or Mann-Whitney U test was applied for the quantitative variables in the univariate analysis. A\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      -value of less than 0.05 was considered significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 27 patients were included in each group. Upper lobe involvement (44%) and pleural effusion (22%) were significantly more common in TB-COVID-19 cases when compared to the control group (7% and 4%, respectively;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). Moreover, median levels of C-reactive protein and ferritin were significantly higher in TB-COVID-19 coinfection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Chest radiology and a higher level of certain biomarkers like C-reactive protein and ferritin can help to suspect TB in COVID-19 patients and vice-versa.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_791_23","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T16:06:22Z","timestamp":1702915582000},"page":"3200-3203","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["COVID-19 and tuberculosis coinfection: A case\u2013control study from a tertiary care center in South India"],"prefix":"10.4103","volume":"12","author":[{"given":"Druti","family":"Hazra","sequence":"first","affiliation":[{"name":"Department of Microbiology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayana","family":"Siddalingaiah","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Chawla","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Ravindra","family":"Prabhu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Datta","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisha","family":"Khader","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilna Muttickal","family":"Swaminathan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kasturba Medical College, 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