{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:38:41Z","timestamp":1787071121426,"version":"build-2736575974"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Acute febrile illness (AFI) is the common presentation in tropical countries like India, particularly during the monsoon season. The diagnostic challenge in resource-limited settings often leads to presumptive management without identifying the specific etiology. Understanding the clinical spectrum and etiology of AFI is crucial for timely diagnosis and effective treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To evaluate the clinical, biochemical, and radiological profiles of adult patients admitted with acute febrile illness during the monsoon months over three consecutive years and to identify the prevalent infections and their outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This cross-sectional observational study was conducted at a tertiary care hospital in Nagpur during the monsoon months (June to September) for three successive years (2022-2024). A total of 300 adult patients presenting with fever of less than 14 days duration were included after obtaining informed consent. Clinical history, examination, and relevant laboratory and radiological investigations were performed. The etiology was confirmed using serological tests, blood cultures, and imaging. Treatment and outcomes were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Out of the total 300 patients, dengue fever was the most common diagnosis (33%), followed by lower respiratory tract infections (12%), acute gastroenteritis (11.4%), upper respiratory tract infections (10.7%), and malaria (7.8%). Other etiologies included urinary tract infection, enteric fever, scrub typhus, acute viral hepatitis, meningitis\/encephalitis, and leptospirosis. In 8.5% of cases, the etiology remained unidentified. Most patients responded well to empirical therapy, and the overall outcome was favorable with low mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Dengue remains the predominant cause of AFI during the monsoon season, followed by bacterial and protozoal infections. Accurate etiological diagnosis supported by appropriate investigations can help reduce morbidity. The findings emphasize the need for improved diagnostic facilities and seasonal surveillance to manage AFI effectively in endemic regions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_797_25","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T12:01:26Z","timestamp":1774008086000},"page":"927-932","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Clinical profile of patients presenting with acute febrile illness during monsoon season for 3 successive years - A cross sectional observational study"],"prefix":"10.4103","volume":"15","author":[{"given":"Sunanda A.","family":"Chaoji","sequence":"first","affiliation":[{"name":"Department of Medicine, NKPSIMS and RC and LMH, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankita","family":"Shelke","sequence":"additional","affiliation":[{"name":"Department of Medicine, NKPSIMS and RC and LMH, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Diwakar","sequence":"additional","affiliation":[{"name":"Department of Medicine, NKPSIMS and RC and LMH, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,3,20]]},"reference":[{"key":"R1-20260325","first-page":"3399","article-title":"Clinical profile of dengue fever in a teaching hospital","volume":"4","author":"Kashinkunti","year":"2013","journal-title":"Int J Biol Med Res"},{"key":"R2-20260325","first-page":"623","article-title":"Frequency of leptospirosis in patients of acute febrile illness in Uttar Pradesh","volume":"52","author":"Manocha","year":"2004","journal-title":"J Assoc Physicians India"},{"key":"R3-20260325","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1186\/1471-2334-13-355","article-title":"Fever in the tropics: Aetiology and case-fatality - A prospective observational study in a tertiary care hospital in South India","volume":"13","author":"Abrahamsen","year":"2013","journal-title":"BMC Infect Dis"},{"key":"R4-20260325","doi-asserted-by":"crossref","first-page":"393","DOI":"10.4269\/ajtmh.2008.78.393","article-title":"Non-malarial acute undifferentiated fever in a rural hospital in central India","volume":"78","author":"Hoshi","year":"2008","journal-title":"Am J Trop Med Hyg"},{"key":"R5-20260325","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/trstmh\/trt120","article-title":"Time for a comprehensive approach to the syndrome of fever in the tropics","volume":"108","author":"Crump","year":"2014","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"R6-20260325","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4103\/0972-9062.213380","article-title":"Climate change and human health: Indian context","volume":"49","author":"Singh","year":"2012","journal-title":"J Vector Borne Dis"},{"key":"R7-20260325","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4103\/0255-0857.148381","article-title":"Chaudhury A seroprevalence of acute undifferentiated febrile illness at a tertiary care hospital","volume":"33","author":"Ramyasree","year":"2015","journal-title":"Indian J Med Microbiol"},{"key":"R8-20260325","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1046\/j.1365-3156.2002.00827.x","article-title":"Use of clinical algorithms for diagnosing malaria","volume":"7","author":"Chandramohan","year":"2002","journal-title":"Trop Med Int Health"},{"key":"R9-20260325","first-page":"122","article-title":"A study of acute febrile illness","volume":"45","author":"Abraham","year":"2015","journal-title":"Trop Doct"},{"key":"R10-20260325","first-page":"719","article-title":"Acute undifferentiated fever in Asia: A review of the literature","volume":"45","author":"Susilawati","year":"2014","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"R11-20260325","doi-asserted-by":"crossref","first-page":"757","DOI":"10.22207\/JPAM.12.2.36","article-title":"Clinical and microbiological profile of patients with acute febrile illness attending a tertiary care hospital in South India","volume":"12","author":"Arvind","year":"2018","journal-title":"J Pure Appl Microbiol"},{"key":"R12-20260325","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4103\/cmi.cmi_39_19","article-title":"Acute undifferentiated febrile illness in the elderly: A clinical profile","volume":"17","author":"Hazra","year":"2019","journal-title":"Curr Med Issues"},{"key":"R13-20260325","first-page":"1719","article-title":"To study the prevalence of aetiologies of acute undifferentiated febrile illnesses of the patients at a tertiary care centre in Uttar Pradesh, India","volume":"30","author":"Mishra","year":"2023","journal-title":"J Popul Ther Clin Pharmacol"},{"key":"R14-20260325","first-page":"37","article-title":"A study of clinical profile of patients presenting with complications of acute febrile illnesses during monsoon","volume":"65","author":"Salagre","year":"2017","journal-title":"J Assoc Physicians India"},{"key":"R15-20260325","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4103\/0974-777X.192966","article-title":"Acute undifferentiated febrile illness in patients presenting to a tertiary care hospital in South India: Clinical spectrum and outcome","volume":"8","author":"Abhilash","year":"2016","journal-title":"J Glob Infect Dis"},{"key":"R16-20260325","first-page":"109","article-title":"Distribution of typhoid fever in different rural and urban areas of lakhimpur district of Assam","volume":"1","author":"Sharma","year":"2013","journal-title":"Int J Res Dev Health"},{"key":"R17-20260325","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1097\/INF.0b013e3181e39f8b","article-title":"Incidence of typhoid bacteremia in infants and young children in southern coastal Pakistan","volume":"29","author":"Owais","year":"2010","journal-title":"Pediatr Infect Dis J"},{"key":"R18-20260325","doi-asserted-by":"crossref","first-page":"555","DOI":"10.17511\/jopm.2019.i08.08","article-title":"Prevalence of acute undifferentiated febrile illnesses in a tertiary care centre in Telangana, South India","volume":"5","author":"Mohan","year":"2019","journal-title":"Trop J Pathol Microbiol"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_797_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:41:47Z","timestamp":1787067707000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_797_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_797_25","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-05-08","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-09","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}