{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:46:02Z","timestamp":1788176762047,"version":"build-2803163510"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Background:<\/jats:title>\n Sepsis, the second most common cause of neonatal mortality, causes more than one million deaths annually. India has the highest incidence of clinical sepsis (17000\/100000 live birth).<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n This study aimed to determine the risk factors and organisms of early-onset neonatal sepsis (EONS) in a tertiary care hospital in Northeast India.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n It was a case\u2013control study conducted in the neonatal unit of MGM Medical College, Kishanganj, Bihar, from January 2022 to April 2023. All neonates admitted to the neonatal intensive care unit (NICU) within 72 hours of life constituted the study population. Neonates diagnosed as EONS by clinical and laboratory parameters were considered as cases and those not diagnosed for EONS as controls. Maternal and newborn information and laboratory parameters were collected and analyzed. For risk factor identification, the bivariate logistic regression was used.<\/jats:p>\n <\/jats:sec>\n \n Result:<\/jats:title>\n \n An equal number of cases (78) and control (78) were enrolled in the study. Maternal age >30 years (adjusted odds ratio [aOR] = 3.017, confidence interval [CI]: 1.238 to 7.352;\n P<\/jats:italic>\n < 0.015), maternal urinary tract infection (UTI) in the third trimester (aOR = 5.435, CI: 2.647 to 11.158;\n P<\/jats:italic>\n < 0.0001), and premature rupture of membranes (PROM) (aOR = 2.918, CI: 4.61 to 33.73,\n P<\/jats:italic>\n < 0.004) were significant predictors of EONS. Pseudomonas (41.02%), Klebsiella (16.66%), and coagulase-negative\n Staphylococcus aureus<\/jats:italic>\n (20.51%) were commonly isolated organisms, which were highly resistant to cephalosporin, meropenem, aminoglycosides, and quinolones.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Proper and adequate antenatal screening for diagnosis and treatment of maternal infection and high-risk pregnancies for perinatal management of newborn is recommended to prevent neonatal sepsis-related morbidity and mortality. Rational use of antibiotics may minimize the hazard of antibiotic resistance.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_807_23","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T06:07:57Z","timestamp":1707372477000},"page":"54-58","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Risk factors and etiology of early-onset neonatal sepsis in Northeastern part of India: Case\u2013control study"],"prefix":"10.4103","volume":"13","author":[{"given":"Sudesh","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Pediatric Medicine, MGM Medical College, Kishanganj, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyali","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Department of Pediatric Medicine, MGM Medical College, Kishanganj, Bihar, 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