{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:02:54Z","timestamp":1787169774950,"version":"build-2736575974"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:p>Primary cutaneous apocrine carcinoma (PCAC) is an extremely rare malignancy. Distinguishing apocrine carcinoma from breast carcinoma metastasis is difficult. Only a few cases reported as PCAC of the scalp and primarily treated by wide local excision. The usual presentation is a skin lesion that rapidly progresses over the duration of a few weeks to few months. We reported a 56-year-old man with a right scalp ulcerative lesion diagnosed as a CAC. The patient underwent wide local excision. 1.5 years later, the patient developed neck lymph node metastasis that treated with neck dissection and adjuvant radiotherapy. No chemotherapy was given due to limited literature, suggesting substantial benefits of adjuvant chemotherapy for such cases. Review literature was performed to assess the clinical presentation, treatment, and prognosis of such malignancies. PCAC of the scalp is a challenging malignancy in the diagnosis and management.<\/jats:p>","DOI":"10.4103\/jfmpc.jfmpc_833_19","type":"journal-article","created":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T00:29:28Z","timestamp":1574036968000},"page":"3758-3762","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Apocrine carcinoma of the scalp with neck lymph node metastasis: A case report and review of the literature"],"prefix":"10.4103","volume":"8","author":[{"given":"Hadi","family":"Al-Hakami","sequence":"first","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, King Abdullah International Medical Research Center, National Guard Health Affairs, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baraa I.","family":"Awad","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, King Abdullah International Medical Research Center, National Guard Health Affairs, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Al-Garni","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, King Abdullah International Medical Research Center, National Guard Health Affairs, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haneen A.","family":"Al-Maghrabi","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noura","family":"Al-Shareef","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, King Abdullah International Medical Research Center, National Guard Health Affairs, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,11]]},"reference":[{"key":"R1-20260528","doi-asserted-by":"crossref","first-page":"356","DOI":"10.15761\/GOD.1000188","article-title":"Treatment of primary cutaneous apocrine carcinoma of the scalp-case and review of the literature","volume":"3","author":"Brown","year":"2016","journal-title":"Glob Dermatol"},{"key":"R2-20260528","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1177\/030089160008600608","article-title":"Clinical management of a case of recurrent apocrine gland carcinoma of the scalp: Efficacy of a chemotherapy schedule with methotrexate and bleomycin","volume":"86","author":"Morabito","year":"2000","journal-title":"Tumori"},{"key":"R3-20260528","first-page":"209","article-title":"Apocrine carcinoma of the scalp with aggressive clinical course--A case report and review of the literature","volume":"36","author":"Vucini\u0107","year":"2012","journal-title":"Coll Antropol"},{"key":"R4-20260528","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/jso.22023","article-title":"Cutaneous apocrine adenocarcinoma: Defining epidemiology, outcomes, and optimal therapy for a rare neoplasm","volume":"105","author":"Hollowell","year":"2012","journal-title":"J Surg Oncol"},{"key":"R5-20260528","first-page":"141","article-title":"The elusive differential diagnosis of cutaneous apocrine adenocarcinoma vs. metastasis: The current role of clinical correlation","volume":"18","author":"Fernandez-Flores","year":"2009","journal-title":"Acta Dermatovenerol Alp Pannonica Adriat"},{"key":"R6-20260528","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0190-9622(79)80100-0","article-title":"Malignant neoplasms associated with nevus sebaceus of Jadassohn","volume":"1","author":"Domingo","year":"1979","journal-title":"J Am Acad Dermatol"},{"key":"R7-20260528","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1136\/jcp.2004.019794","article-title":"Axillary apocrine carcinoma with benign apocrine tumours: A case report involving a pathological and immunohistochemical study and review of the literature","volume":"58","author":"Miyamoto","year":"2005","journal-title":"J Clin Pathol"},{"key":"R8-20260528","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1159\/000335244","article-title":"Primary cutaneous apocrine carcinoma of sweat glands: A rare case report","volume":"4","author":"Vasilakaki","year":"2011","journal-title":"Case Rep Oncol"},{"key":"R9-20260528","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/1097-0142(19930115)71:2<375::AID-CNCR2820710218>3.0.CO;2-4","article-title":"Apocrine carcinoma of the skin. A clinicopathologic, immunocytochemical, and ultrastructural study","volume":"71","author":"Paties","year":"1993","journal-title":"Cancer"},{"key":"R10-20260528","doi-asserted-by":"crossref","first-page":"e412","DOI":"10.1200\/JCO.2009.26.1891","article-title":"Metastatic apocrine carcinoma of the scalp: Prolonged response to systemic chemotherapy","volume":"28","author":"Tlemcani","year":"2010","journal-title":"J Clin Oncol"},{"key":"R11-20260528","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3126\/kumj.v10i2.7356","article-title":"Apocrine carcinoma developing in a naevus sebaceous of scalp","volume":"10","author":"Paudel","year":"2012","journal-title":"Kathmandu Univ Med J (KUMJ)"},{"key":"R12-20260528","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/00000372-199808000-00012","article-title":"Tubular apocrine carcinoma arising in a nevus sebaceus of Jadassohn","volume":"20","author":"Jacyk","year":"1998","journal-title":"Am J Dermatopathol"},{"key":"R13-20260528","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s11060-005-9039-3","article-title":"Brain metastases from apocrine carcinoma of the scalp: Case report","volume":"77","author":"Shimato","year":"2006","journal-title":"J Neurooncol"},{"key":"R14-20260528","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1097\/PAS.0b013e3181590ba4","article-title":"Primary cutaneous apocrine carcinoma: A clinico-pathologic analysis of 24 cases","volume":"32","author":"Robson","year":"2008","journal-title":"Am J Surg Pathol"},{"key":"R15-20260528","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1016\/j.bjps.2011.11.001","article-title":"Primary apocrine carcinoma of scalp: Report of primary scalp cutaneous apocrine carcinoma indistinguishable from cutaneous metastasis of breast carcinoma","volume":"65","author":"Kim","year":"2012","journal-title":"J Plast Reconstr Aesthetic Surg"},{"key":"R16-20260528","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/00000421-199904000-00005","article-title":"Apocrine gland carcinoma of the axilla: Review of the literature and recommendations for treatment","volume":"22","author":"Chamberlain","year":"1999","journal-title":"Am J Clin Oncol"},{"key":"R17-20260528","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1097\/00005537-200310000-00031","article-title":"Cutaneous head and neck squamous cell carcinoma metastatic to cervical lymph nodes (nonparotid): A better outcome with surgery and adjuvant radiotherapy","volume":"113","author":"Veness","year":"2003","journal-title":"Laryngoscope"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_833_19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:12:33Z","timestamp":1787166753000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_833_19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":17,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_833_19","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"2019-09-26","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-13","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}