{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:24:33Z","timestamp":1787757873580,"version":"build-2784847793"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>In recent times, single-sitting root canal therapy has gained momentum over multiple-sitting root canal therapy due to its superior clinical outcome and less time required for treating the patient. Aim: Thus, the aim of current study was to compare the expression of interleukin-6 (IL-6), tumor necrosis factor-\u03b1 (TNF-\u03b1), and high-sensitivity C-reactive protein (hs-CRP) in the serum of patients undergoing single-sitting and multiple-sitting root canal treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      This cross-sectional experimental study was conducted on 300 subjects who were indicated for root canal treatment. Subjects were categorized into Group I (single visit) and Group II (multiple visits).Clinical data was obtained and serum samples were collected both before and after 1 week of treatment completion. Inclusion criteria were those patients (a) over 18 years of age, (b) without any disease of inflammatory etiology, and (c) who had not previously received endodontic treatment or any related therapeutic treatment. Exclusion criteria were those (a) without a complete clinical history, (b) with greater than one indicated tooth, (c) who did not complete their treatment, and (d) with any periodontal disease. Chi-square and Student\u2019s\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test were applied.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>It was found that in single-sitting root canal treatment, there was a statistically significant reduction in these inflammatory biomarkers, although no difference in clinical efficacy was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Single-visit root canal treatment is a better option for treatment of pulpitis compared to multiple-sitting treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_846_21","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T07:41:10Z","timestamp":1653464470000},"page":"1918-1922","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Expression of IL-6, TNF-\u03b1, and hs-CRP in the serum of patients undergoing single-sitting and multiple-sitting root canal treatment"],"prefix":"10.4103","volume":"11","author":[{"given":"Rohit","family":"Agrawal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Bhardwaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonita","family":"Doley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhigyan","family":"Manas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabu Mahin Syed","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prajakta B.","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishore K.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-54-20240828","first-page":"44","article-title":"Postoperative pain following treatment of teeth with irreversible pulpitis:A review","volume":"83","author":"Mohammadi","year":"2017","journal-title":"N Y State Dent J"},{"key":"R2-54-20240828","first-page":"669","article-title":"Comparative study of pain releasing effect of two approaches to acute pulpitis in the night emergency","volume":"26","author":"Liu","year":"2017","journal-title":"Shanghai Kou Qiang Yi Xue"},{"key":"R3-54-20240828","first-page":"966","article-title":"Evaluation of salivary total proteins albumin, globulin, and A\/G ratio among healthy individuals and patients with chronic pulpitis","volume":"10","author":"Karthikeson","year":"2018","journal-title":"Drug Invent Today"},{"key":"R4-54-20240828","first-page":"259","article-title":"Comparative molecular analysis of gram-negative bacteria in primary teeth with irreversible pulpitis or periapical pathology","volume":"40","author":"Nelson-Filho","year":"2018","journal-title":"Pediatr Dent"},{"key":"R5-54-20240828","doi-asserted-by":"crossref","first-page":"1","DOI":"10.17796\/1053-4628-40.1.1","article-title":"Does smear layer removal influence root canal therapy outcome?A systematic review","volume":"40","author":"Pintor","year":"2016","journal-title":"J Clin Pediatr Dent"},{"key":"R6-54-20240828","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.joen.2013.09.024","article-title":"Comparison between prescription of regular or on-demand ibuprofen on postoperative pain after single-visit root canal treatment of teeth with irreversible pulpitis","volume":"40","author":"Parirokh","year":"2014","journal-title":"J Endod"},{"key":"R7-54-20240828","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/j.1600-051X.1997.tb01192.x","article-title":"Substance P and neurokinin A in gingival crevicular fluid in periodontal health and disease","volume":"24","author":"Linden","year":"1997","journal-title":"J Clin Periodontol"},{"key":"R8-54-20240828","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1056\/NEJM199902113400607","article-title":"Acute-phase proteins and other systemic responses to inflammation","volume":"340","author":"Gabay","year":"1999","journal-title":"N Engl J Med"},{"key":"R9-54-20240828","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1161\/01.CIR.0000053730.47739.3C","article-title":"Clinical application of C-Reactive protein for cardiovascular disease detection and prevention","volume":"107","author":"Redker,","year":"2003","journal-title":"Circulation"},{"key":"R10-54-20240828","first-page":"106","article-title":"Interleukin-6 and high sensitivity C-reactive protein correlation in atherosclerosis in Iraqi type 2 diabetic patients","volume":"5","author":"Rasheed","year":"2013","journal-title":"Int J Drug Dev Res"},{"key":"R12-54-20240828","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/iej.13467","article-title":"The global prevalence of apical periodontitis:A systematic review and meta-analysis","volume":"54","author":"Tib\u00farcio-Machado","year":"2021","journal-title":"Int Endod J"},{"key":"R13-54-20240828","doi-asserted-by":"crossref","first-page":"2","DOI":"10.25259\/AJOHAS_1_2020","article-title":"Pre- and post-treatment levels of serum high-sensitivity C-reactive protein in patients with lesions of endodontic origin:A clinical pilot study","volume":"10","author":"Bains","year":"2020","journal-title":"Asian J Oral Health Allied Sci"},{"key":"R14-54-20240828","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/0300060519879287","article-title":"Therapeutic effect of one-time root canal treatment for irreversible pulpitis","volume":"48","author":"Lu","year":"2020","journal-title":"J Int Med Res"},{"key":"R15-54-20240828","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1111\/iej.12567","article-title":"Association between apical periodontitis lesions and plasmatic levels of C-reactive protein, interleukin 6 and fibrinogen in hypertensive patients","volume":"49","author":"Vidal","year":"2016","journal-title":"Int Endod J"},{"key":"R16-54-20240828","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.joen.2014.12.021","article-title":"C-reactive protein expression is upregulated in apical lesions of endodontic origin in association with interleukin-6","volume":"41","author":"Garrido","year":"2015","journal-title":"J Endod"},{"key":"R17-54-20240828","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/iej.13444","article-title":"Impact of root canal treatment on high-sensitivity C-reactive protein levels in systemically healthy adults with apical periodontitis-a preliminary prospective, longitudinal interventional study","volume":"54","author":"Poornima","year":"2021","journal-title":"Int Endod J"},{"key":"R18-54-20240828","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.joen.2010.04.018","article-title":"Biologic markers for odontogenic periradicular periodontitis","volume":"36","author":"Burgener","year":"2010","journal-title":"J Endod"},{"key":"R19-54-20240828","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/sj.bdj.2015.340","article-title":"Does apical periodontitis have systemic consequences?The need for well-planned and carefully conducted clinical studies","volume":"218","author":"Van Der Waal","year":"2015","journal-title":"Br Dent J"},{"key":"R20-54-20240828","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1177\/154405910608500113","article-title":"Full-mouth tooth extraction lowers systemic inflammatory and thrombotic markers of cardiovascular risk","volume":"85","author":"Taylor","year":"2006","journal-title":"J Dent Res"},{"key":"R21-54-20240828","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1067\/moe.2001.115025","article-title":"Effect of interleukin-6 deficiency on the formation of periapical lesions after pulp exposure in mice","volume":"92","author":"Huang","year":"2001","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R22-54-20240828","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S1079-2104(03)00067-2","article-title":"Immunolocalization of interleukin 4 interleukin 6, and lymphotoxin alpha in dental granulomas","volume":"96","author":"de Sa","year":"2003","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R23-54-20240828","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.joen.2013.06.014","article-title":"Can apical periodontitis modify systemic levels of inflammatory markers?A systematic review and meta-analysis","volume":"39","author":"Gomes","year":"2013","journal-title":"J Endod"},{"key":"R24-54-20240828","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1016\/j.joen.2009.09.028","article-title":"Identify and define all diagnostic terms for periapical\/periradicular health and disease states","volume":"35","author":"Gutmann","year":"2009","journal-title":"J Endod"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_846_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:56:09Z","timestamp":1787756169000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_846_21"}},"subtitle":["A comparative study"],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_846_21","relation":{},"ISSN":["2249-4863"],"issn-type":[{"value":"2249-4863","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]}}}