{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:40:59Z","timestamp":1786653659734,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>\n                    Pheniramine maleate is an easily accessible, potent antihistaminic compound used for the treatment of various allergic conditions. It acts on histamine one (H\n                    <jats:sub>1<\/jats:sub>\n                    ) receptors on the central nervous system (CNS) and the peripheral tissues. It is a safe drug in therapeutic doses. However, overdoses as in suicidal cases, can result in serious, life-threatening drug-toxicity. These include atropine-like antimuscarinic effects like dryness of mucosal membranes, blurring of vision, hallucinations, CNS excitation such as irritability, insomnia, and seizures. Rhabdomyolysis can also occur as a result of its direct toxic effect on muscles, resulting in myoglobinuria, renal failure and electrolyte imbalance. Cardiotoxicity though rare, is also reported. We report a case of pheniramine maleate induced ventricular tachycardia, myoglobinuria with acute kidney injury (AKI) in a 20-year-old man who had consumed 50 tablets. He was incidentally also found to have SARS-CoV\n                    <jats:sub>2<\/jats:sub>\n                    infection. However, timely intervention and aggressive supportive therapy helped in the recovery of the patient.\n                  <\/jats:p>","DOI":"10.4103\/jfmpc.jfmpc_853_22","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T03:51:56Z","timestamp":1675050716000},"page":"7953-7956","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Spectrum of toxicity due to pheniramine overuse in a COVID-19 patient. How much do we know?"],"prefix":"10.4103","volume":"11","author":[{"given":"Sangita D.","family":"Kamath","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Tata Main Hospital, Tata Steel, Jamshedpur, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajatshatru","family":"Upadhaya","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Tata Main Hospital, Tata Steel, Jamshedpur, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelam","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Pathology and Tata Main Hospital, Tata Steel, Jamshedpur, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabhakar","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Tata Main Hospital, Tata Steel, Jamshedpur, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"key":"R2-20260204","doi-asserted-by":"crossref","first-page":"319","DOI":"10.4103\/0971-6580.155384","article-title":"Pheniramine maleate-induced rhabdomyolysis and AKI: Is it fatal?","volume":"21","author":"Venugopal","year":"2014","journal-title":"Toxicol Int"},{"key":"R3-20260204","doi-asserted-by":"crossref","first-page":"221","DOI":"10.4103\/0972-5229.60176","article-title":"Acute renal failure caused by pheniramine maleate induced rhabdomyolysis: An unusual case","volume":"13","author":"Paul","year":"2009","journal-title":"Indian J Crit Care Med"},{"key":"R4-20260204","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3109\/15563659309000418","article-title":"Non-traumatic rhabdomyolysis complicating antihistamine overdose","volume":"31","author":"Frankel","year":"1993","journal-title":"J Toxicol Clin Toxicol"},{"key":"R5-20260204","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1080\/00325481.1993.11701728","article-title":"Severe rhabdomyolysis after doxylamine overdose","volume":"93","author":"Soto","year":"1993","journal-title":"Postgrad Med"},{"key":"R6-20260204","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1136\/pgmj.69.811.333","article-title":"Drug- induced rhabdomyolysis: Mechanisms and management","volume":"69","author":"Prendergast","year":"1993","journal-title":"Postgrad Med J"},{"key":"R7-20260204","doi-asserted-by":"crossref","first-page":"525","DOI":"10.5144\/0256-4947.1998.525","article-title":"Drug-induced rhabdomyolysis","volume":"18","author":"Larbi","year":"1998","journal-title":"Ann Saudi Med"},{"key":"R8-20260204","first-page":"1978210201","article-title":"Cardiotoxicity of H1-antihistamines","volume":"7","author":"Mart\u00ednez","year":"2018","journal-title":"J Anal Pharm Res"},{"key":"R9-20260204","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s41232-020-00140-9","article-title":"Renal complications in coronavirus disease 2019: A systematic review","volume":"40","author":"Minami","year":"2020","journal-title":"Inflamm Regen"},{"key":"R10-20260204","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1345\/aph.1C241","article-title":"Rhabdomyolysis and acute renal failure following an ethanol and diphenhydramine overdose","volume":"37","author":"Haas","year":"2003","journal-title":"Ann Pharmacother"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_853_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:40:37Z","timestamp":1786650037000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_853_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":9,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_853_22","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"2022-04-13","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-23","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}