{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T04:27:21Z","timestamp":1792988841140,"version":"4.5.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Acanthosis nigricans (AN) is a common finding often associated with hyperinsulinemia and childhood obesity. There has been a lack of studies evaluating the association of AN with underlying cardio-metabolic risk factors in children and adolescents. Our objective was to study the association between AN and cardio-metabolic risk factors in children with overweight\/obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This cross-sectional study included school-going children (6\u201316 years of age) with overweight\/obesity. Physical examination, anthropometry, and blood pressure (BP) data were collected. Fasting blood samples were collected to measure insulin, glucose, homeostasis model assessment index (HOMAIR), and lipid profile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of 1930 children screened, 545 had overweight\/obesity, and were included. Boys to girls ratio was 1.27. AN was present in 46.4% of children. Children with AN had higher body mass index [BMI] (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01), waist circumference [WC] (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01), systolic (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03), and diastolic BP (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02), hyperglycemia (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02), hyperinsulinemia (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01), and a higher HOMA-IR (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01) compared to those without AN. HDL level was lower in children with AN.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Children with overweight\/obesity who have AN have significant elevations of BP, insulin level, and HOMA-IR. AN is a clinical marker that seems to be associated with cardio-metabolic risk factors in children with overweight\/obesity in the given study population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_866_24","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T09:04:37Z","timestamp":1736759077000},"page":"254-258","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Acanthosis nigricans and its association with cardio-metabolic risk factors in children with overweight\/obesity: A school-based cross-sectional study"],"prefix":"10.4103","volume":"14","author":[{"given":"Rashmi R.","family":"Das","sequence":"first","affiliation":[{"name":"Department of Pediatrics, AIIMS, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manaswini","family":"Mangaraj","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, AIIMS, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurav","family":"Nayak","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, AIIMS, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit K.","family":"Satapathy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, AIIMS, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samarendra","family":"Mahapatro","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, AIIMS, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"R1-20260109","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4103\/0970-0218.112452","article-title":"Insulin resistance and cardio metabolic abnormalities among overweight South Indian children:Chennai slim and fit programme","volume":"38","author":"Tharkar","year":"2013","journal-title":"Indian J Community Med"},{"key":"R2-20260109","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/sj.ijo.0802704","article-title":"High prevalence of insulin resistance in postpubertal Asian Indian children is associated with adverse truncal body fat patterning, abdominal adiposity and excess body fat","volume":"28","author":"Misra","year":"2004","journal-title":"Int J Obes Relat Metab Disord"},{"key":"R3-20260109","doi-asserted-by":"crossref","first-page":"44","DOI":"10.4103\/2230-8210.91187","article-title":"Metabolic syndrome in South Asians","volume":"16","author":"Pandit","year":"2012","journal-title":"Indian J Endocrinol Metab"},{"key":"R4-20260109","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/apa.15031","article-title":"Acanthosis nigricans in childhood:A cutaneous marker that should not be underestimated, especially in obese children","volume":"109","author":"Maguolo","year":"2020","journal-title":"Acta Paediatr"},{"key":"R5-20260109","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1590\/S0365-05962012000400002","article-title":"Acanthosis nigricans and insulin resistance in overweight children and adolescents","volume":"87","author":"Kluczynik","year":"2012","journal-title":"An Bras Dermatol"},{"key":"R6-20260109","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.jpeds.2014.02.018","article-title":"Waist circumference percentiles in 2-18 year old Indian children","volume":"164","author":"Khadilkar","year":"2014","journal-title":"J Pediatr"},{"key":"R7-20260109","doi-asserted-by":"crossref","first-page":"e20171904","DOI":"10.1542\/peds.2017-1904","article-title":"Subcommittee on screening and management of high blood pressure in children. 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