{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:08:47Z","timestamp":1792415327622,"version":"4.4.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>Hemoglobinopathies and thalassemias are the commonest single gene disorders in India. In Terai region of India, Hemoglobinopathies and thalassemias are the most common in the Tharu community. Therefore, in this study, we aim to evaluate the Hb variant analysis of hemoglobinopathies and thalassemias in a Tharu population in Lakhimpur Kheri Districts of Uttar Pradesh, India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Total 493 individuals were recruited in this study. The demographic details and blood samples were collected from different location at Kheri district during mega health camp. Hb variant analysis was performed by high performance liquid chromatography (HPLC) system beta thalassemia short program in BIO-RAD VARIANT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Out of 493, 108 (21.9%) individual suffers with abnormal haemoglobinopathies. In which \u03b2-thalassemia trait is the commonest haemoglobinopathy (12.98%), followed by HbE trait (7.50%), and compound heterozygous HbS\/\u03b2-Thalassemia trait (1.42%) in overall population. The HbF was significantly greater in HbS heterozygous (1.45 \u00b1 1.41), whereas mean HbA2 was significantly greater in \u03b2-Thalassemia trait (5.17 \u00b1 1.36).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The high incidence of hemoglobinopathies and thalassemias were observed in Tharu community in Lakhimpur Kheri districts of Uttar Pradesh, Indian.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_879_20","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T05:57:47Z","timestamp":1598939867000},"page":"4305-4310","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":17,"title":["A demographic prevalence of \u03b2 Thalassemia carrier and other hemoglobinopathies in adolescent of Tharu population"],"prefix":"10.4103","volume":"9","author":[{"given":"Nitu","family":"Nigam","sequence":"first","affiliation":[{"name":"Department of Center for Advance Research (Cytogenetics Lab), King George's Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Kushwaha","sequence":"additional","affiliation":[{"name":"Department of Pathology, King George's Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geeta","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Pathology, King George's Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prithvi K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Center for Advance Research (Cytogenetics Lab), King George's Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Center for Advance Research (Cytogenetics Lab), King George's Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhupendra","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Clinical Hematology, King George's Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, King George's Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooran","family":"Chand","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, King George's Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailedra K.","family":"Saxena","sequence":"additional","affiliation":[{"name":"Department of Center for Advance Research, King George's Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madan Lal Brahma","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Department of Vice Chancellor, King George's Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,8]]},"reference":[{"key":"R1-20260817","doi-asserted-by":"crossref","first-page":"592","DOI":"10.2174\/156652408786241375","article-title":"Hemoglobinopathies worldwide: Present and future","volume":"8","author":"Weatherall","year":"2008","journal-title":"Curr Mol Med"},{"key":"R2-20260817","doi-asserted-by":"crossref","first-page":"e208","DOI":"10.1097\/HS9.0000000000000208","article-title":"EHA research roadmap on hemoglobinopathies and thalassemia: An update","volume":"3","author":"Iolascon","year":"2019","journal-title":"Hemasphere"},{"key":"R3-20260817","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s13023-017-0643-z","article-title":"Thalassemias in South Asia: clinical lessons learnt from Bangladesh","volume":"12","author":"Hossain","year":"2017","journal-title":"Orphanet J Rare Dis"},{"key":"R4-20260817","doi-asserted-by":"crossref","first-page":"850","DOI":"10.3126\/jpn.v5i10.15642","article-title":"Distribution of hemoglobinopathies in patients presenting for electrophoresis and comparison of result with High performance liquid chromatography","volume":"5","author":"Jha","year":"2015","journal-title":"J Pathol Nepal"},{"key":"R5-20260817","doi-asserted-by":"crossref","first-page":"e2011025","DOI":"10.4084\/mjhid.2011.025","article-title":"Thalassemia and venous thromboembolism","volume":"3","author":"Succar","year":"2011","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"R6-20260817","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1750-1172-5-11","article-title":"Beta-thalassemia","volume":"5","author":"Galanello","year":"2010","journal-title":"Orphanet J Rare Dis"},{"key":"R7-20260817","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1258\/jms.2010.009075","article-title":"Implementing neonatal screening for haemoglobinopathies in the Netherlands","volume":"17","author":"Bouva","year":"2010","journal-title":"J Med Screen"},{"key":"R8-20260817","doi-asserted-by":"crossref","first-page":"e2014046","DOI":"10.4084\/mjhid.2014.046","article-title":"Cost of hematopoietic stem cell transplantation in India","volume":"6","author":"Sharma","year":"2014","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"R9-20260817","first-page":"309","article-title":"Advantages in the use of high performance chromatography technique for screening hemoglobinopathies in Venezuela","volume":"45","author":"Bravo-Urquuiola","year":"2004","journal-title":"Invest Clin"},{"key":"R10-20260817","doi-asserted-by":"crossref","first-page":"219","DOI":"10.15406\/icpjl.2016.03.00077","article-title":"Current health status of Uttarakhand, Tharu TRIBE on the basis of blood clinical parameters: A bio-cultural perspective","volume":"3","author":"Rajpoot","year":"2016","journal-title":"Int Clin Pathol J"},{"key":"R11-20260817","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/BF02859390","article-title":"Prevention of thalassemia: A necessity in India","volume":"59","author":"Verma","year":"1992","journal-title":"Indian J Pediatr"},{"key":"R12-20260817","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4103\/0971-6866.64941","article-title":"Frequency of \u03b2-thalassemia trait and other hemoglobinopathies in northern and western India","volume":"16","author":"Madan","year":"2010","journal-title":"Indian J Hum Genet"},{"key":"R13-20260817","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.phoj.2017.10.002","article-title":"Burden of thalassemia in India: The road map for control","volume":"2","author":"Colah","year":"2018","journal-title":"Pediatr Hematol Oncol J"},{"key":"R14-20260817","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1365-2141.1991.tb04423.x","article-title":"The spectrum of beta thalassaemia mutations on the Indian subcontinent: The basis for prenatal diagnosis","volume":"78","author":"Varawalla","year":"1991","journal-title":"Br J Haematol"},{"key":"R15-20260817","first-page":"177","article-title":"The eco-friendly Tharu tribe: A study in socio-cultural dynamics","volume":"1","author":"Verma","year":"2010","journal-title":"J Asia Pac Stud"},{"key":"R16-20260817","first-page":"189","article-title":"Health care strategies, genetic load, and prevention of hemoglobinopathies in tribal communities in India","volume":"4","author":"Balgir","year":"2004","journal-title":"South Asian Anthropologist"},{"key":"R18-20260817","doi-asserted-by":"crossref","first-page":"505","DOI":"10.4103\/0971-5916.159488","article-title":"Haemoglobinopathies in tribal populations of India","volume":"141","author":"Ghosh","year":"2015","journal-title":"Indian J Med Res"},{"key":"R19-20260817","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1080\/10245330600840180","article-title":"Anemia and hemoglobinopathies in tribal population of Eastern and North eastern India","volume":"11","author":"De","year":"2006","journal-title":"Hematology"},{"key":"R21-20260817","doi-asserted-by":"crossref","first-page":"219","DOI":"10.4103\/2249-4863.141614","article-title":"Spectrum of hemoglobin variants in the population of northern region of West Bengal: An ethnogenetic proposition","volume":"3","author":"Goswami","year":"2014","journal-title":"J Family Med Prim Care"},{"key":"R22-20260817","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s12687-012-0114-0","article-title":"Prevalence of \u03b2-thalassemia and other haemoglobinopathies in six cities in India: A multicentre study","volume":"4","author":"Mohanty","year":"2013","journal-title":"J Community Genet"},{"key":"R23-20260817","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3126\/jpn.v3i6.8989","article-title":"Analysis of sickle hemoglobin","volume":"3","author":"Shrestha","year":"2013","journal-title":"J Pathol Nepal"},{"key":"R24-20260817","first-page":"148","article-title":"Changing pattern of Hb electrophoresis and HbA2 levels in \u03b2 thalassemia major","volume":"4","author":"Paunipagar","year":"2010","journal-title":"Indian J Prev Soc Med"},{"key":"R25-20260817","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s12288-008-0005-z","article-title":"Hematological profile of sickle cell disease in central India","volume":"23","author":"Shrikhande","year":"2007","journal-title":"Indian J Hematol Blood Transfus"},{"key":"R27-20260817","doi-asserted-by":"crossref","first-page":"748939","DOI":"10.5402\/2011\/748939","article-title":"Hemoglobin disorders in South India","volume":"2011","author":"Chandrashekar","year":"2011","journal-title":"ISRN Hematol"},{"key":"R28-20260817","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/labmed\/lmx083","article-title":"Comparison of HbA2, E, F and red cell parameters in homozygous HbE with and without \u03b10-thalassemia trait","volume":"49","author":"Pornprasert","year":"2018","journal-title":"Lab Med"},{"key":"R30-20260817","doi-asserted-by":"crossref","first-page":"305","DOI":"10.24953\/turkjped.2016.03.013","article-title":"\u201cSilent\u201d \u03b2-thalassemia mutation (promoter nt-101 C>T) with increased hemoglobin A2","volume":"58","author":"Aslan","year":"2016","journal-title":"Turk J Pediatr"},{"key":"R31-20260817","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1182\/asheducation-2007.1.79","article-title":"Hemoglobin e syndromes","author":"Vichinsky","year":"2007","journal-title":"Hematology Am Soc Hematol Educ Program"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_879_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:18:39Z","timestamp":1787843919000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_879_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":27,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_879_20","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"2020-05-16","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-02","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}