{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:21:31Z","timestamp":1787840491473,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,2]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Background:<\/jats:title>\n Young adults suffering from Type 1 Diabetes mellitus may have diabetic peripheral neuropathy without any signs and symptoms, as one of the complications. Nerve conduction study is routinely used for evaluation of neuromuscular function. This study aimed to conduct a nerve conduction study in insulin-dependent type 1 diabetes mellitus in children and adolescents.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n It was a cross-sectional, descriptive study conducted on 16 diagnosed cases of diabetes mellitus in children aged between 5\u201315 years and 16 healthy controls. Children were selected based on inclusion criteria from Pediatric and adolescent diabetic clinics who came for follow-up. A motor nerve conduction study of the median, tibial, and common peroneal nerves was recorded, and a sensory nerve conduction study of the median and sural nerves was recorded.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n The percentage of females was 46.4% and males were 53.6%. The age of diabetic children was (mean \u00b1 SD) 9.75 \u00b1 3.53 and healthy control was 10.75 \u00b1 3.14. A comparison of sensory nerve conduction parameters between type one diabetes in children and healthy control; onset latency of the sural nerve was prolonged on the bilateral side in diabetes children. Similarly, the SNAP amplitude of the median and sural nerves was decreased in diabetes children.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n In type 1 diabetes in children, peripheral nerves get affected even in asymptomatic patients in children. More disease duration and uncontrolled glucose levels will lead to the involvement of nerves getting affected. Proper follow-up is needed for better management.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_884_24","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T07:03:06Z","timestamp":1740034986000},"page":"633-636","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of nerve conduction studies in insulin-dependent diabetes in children and adolescents at the tertiary care center in eastern Nepal"],"prefix":"10.4103","volume":"14","author":[{"given":"Shital","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Basic and Clinical Physiology, B.P. Koirala Institute of Health Sciences, Dharan, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Khadka","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Physiology, B.P. Koirala Institute of Health Sciences, Dharan, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priza","family":"Subedi","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Physiology, B.P. Koirala Institute of Health Sciences, Dharan, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmala","family":"Limbu","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Physiology, B.P. Koirala Institute of Health Sciences, Dharan, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti","family":"Agrawal","sequence":"additional","affiliation":[{"name":"P.T. Birta City Hospital and Research Centre, Birtamod, Jhapa, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilip","family":"Thakur","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Physiology, B.P. Koirala Institute of Health Sciences, Dharan, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,2,21]]},"reference":[{"issue":"(Suppl 1)","key":"R2-20260109","first-page":"S1","article-title":"Introduction: Standards of Medical Care in Diabetes-2018","volume":"41","year":"2018","journal-title":"Diabetes Care"},{"issue":"(Suppl 27)","key":"R4-20260109","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/pedi.12742","article-title":"ISPAD clinical practice consensus guidelines 2018: Microvascular and macrovascular complications in children and adolescents","volume":"19","author":"Donaghue","year":"2018","journal-title":"Pediatr Diabetes"},{"key":"R5-20260109","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/pedi.13153","article-title":"Diabetic neuropathy in children and youth: New and emerging risk factors","volume":"22","author":"Akinci","year":"2021","journal-title":"Pediatr 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diabetes","volume":"24","author":"Riihimaa","year":"2001","journal-title":"Diabetes Care"},{"key":"R9-20260109","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1399-5448.2006.00213.x","article-title":"Neuropathies in children and adolescents with diabetes: The tip of the iceberg","volume":"7","author":"Vinik","year":"2006","journal-title":"Pediatr Diabetes"},{"key":"R10-20260109","first-page":"132","article-title":"Prevalence and related risk-factors of peripheral neuropathy in children with insulin-dependent diabetes mellitus","volume":"18","author":"Hasani","year":"2013","journal-title":"J Res Med Sci"},{"key":"R11-20260109","doi-asserted-by":"crossref","first-page":"583","DOI":"10.18203\/2349-3291.ijcp20190691","article-title":"Clinical Profile of type 1 diabetes mellitus among children in eastern Nepal","volume":"6","author":"Muktan","year":"2019","journal-title":"Int J Contemp Pediatr"},{"key":"R12-20260109","doi-asserted-by":"crossref","first-page":"184","DOI":"10.4236\/jbbs.2019.94016","article-title":"Frequency and determinants of peripheral neuropathy in diabetic children in Sohag, Egypt","volume":"9","author":"Mohamed","year":"2019","journal-title":"J Behav Brain Sci"},{"key":"R13-20260109","article-title":"Electrophysiological characterization of neuropathy complicating type 1 diabetes mellitus","author":"Abuelwafaa","year":"2019","journal-title":"J Diabetes Res 2019"},{"key":"R14-20260109","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.braindev.2022.01.001","article-title":"Vitamin D and nerve conduction in pediatric type-1 diabetes mellitus","volume":"44","author":"Polat","year":"2022","journal-title":"Brain Dev"},{"key":"R15-20260109","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.diabres.2004.07.017","article-title":"The electrophysiological findings of subclinical neuropathy in patients with recently diagnosed type 1 diabetes mellitus","volume":"67","author":"Karsidag","year":"2005","journal-title":"Diabetes Res Clin Pract"},{"key":"R16-20260109","doi-asserted-by":"crossref","first-page":"386","DOI":"10.2337\/diacare.14.5.386","article-title":"Role of height and glycosylated hemoglobin in abnormal nerve conduction in pediatric patients with type I diabetes mellitus after 4-9 yr of disease","volume":"14","author":"Duck","year":"1991","journal-title":"Diabetes Care"},{"key":"R17-20260109","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1089\/ars.2009.2484","article-title":"Hyperglycemia and glycation in diabetic complications","volume":"11","author":"Negre-Salvayre","year":"2009","journal-title":"Antioxid Redox Signal"}],"container-title":["Journal of Family Medicine and Primary 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