{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:21:34Z","timestamp":1787840494239,"version":"build-2784847793"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Dietary sodium and renin-angiotensin system activity are pivotal in causing primary hypertension. Vitamin D levels inversely relate to the renin\u2013angiotensin system. Our study investigates the association between vitamin D fluctuations and blood pressure control in hypertensive patients undergoing general health checkups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>A cross-sectional study enrolled participants with essential hypertension from family medicine clinics at the Aga Khan University Hospital, Karachi, coming for a general health checkup. Data including demographics, Vitamin D levels, blood pressure, factors associated with hypertension, and vitamin D deficiency were noted and analyzed using SPSS 20. Post-stratification chi-square test was applied to check for the association between different categorical variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In a study of 203 hypertensive subjects (mean age: 58.07 \u00b1 11 years, 56.2% male, 63.5% Urdu speaking), 41.4% were smokers, and 63.1% had other comorbidities along with hypertension. Significant vitamin D deficiency was observed in 81.8%, with 55.7% exhibiting uncontrolled blood pressure. Vitamin D levels were significantly associated with blood pressure changes, sun exposure, gender, physical activity, and salt restriction. Smoking and obesity are also correlated with blood pressure changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Pakistan faces significant hypertension and vitamin D deficiency burdens. Our study found a potential link between varying vitamin D levels and blood pressure fluctuations in hypertensive patients, warranting further research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_905_24","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T07:01:00Z","timestamp":1740034860000},"page":"549-555","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Determining correlation between changes in blood pressure and vitamin D levels: Analyzing influencing factors in hypertensive adults at Family Medicine Clinics"],"prefix":"10.4103","volume":"14","author":[{"given":"Aayesha","family":"Butt","sequence":"first","affiliation":[{"name":"Department Family Medicine, Dow University of Health Sciences, Karachi, Sindh, 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