{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:29:21Z","timestamp":1786739361481,"version":"build-2736575974"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Background:<\/jats:title>\n There remains equivocal evidence in terms of glucose-6-phosphate dehydrogenase (G6PD) and malaria occurrence. A case-control study was performed to assess protective relationship of G6PD and other lifestyle factors with malaria.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n One-hundred twenty six medical professionals were randomly selected from a tertiary care clinical institute. Along with demographic and lifestyle details, subjects were interviewed about their history of occurrence of malaria at all in previous 10 years. Their hematological, biochemical, and metabolic profile was assessed clinically as well as by investigations. The analysis was carried out with two groups: (1) those who were subjected with malaria at least once in past 10 years (\n Malaria Ever Group<\/jats:italic>\n ); (2) those who never encountered malaria (Malaria Never Group).\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Out of 126, 65 subjects were in\n Malaria Ever Group<\/jats:italic>\n and 61were in\n Malaria Never Group<\/jats:italic>\n . There was no difference in lifestyle measures, hematological, and biochemical parameters. Mean G6PD levels were found similar in both the groups. Of 61 subjects in \u201cmalaria-never\u201d group, 1 had deficient (1.1 unit\/gm of Hb), 9 had low normal (between 2.5 and 10 units\/gm of Hb), 48 had normal (10.1\u201320.5 units\/gm of Hb), and 3 had higher than normal (>20.5 units\/gm of Hb) G6PD levels. In comparison, 65 participants from \u201cmalaria ever\u201d group, none was deficient, 6 had low normal, 58 had normal, and none had higher than normal G6PD levels. HPLC-based hemoglobin analysis showed significant higher number of participants in \u201cmalaria-never\u201d group having altered hemoglobin. 12 participants had increased hemoglobin A2 levels, of which 10 were in \u201cMalaria Occurrence Never\u201d group; of them 6 could be diagnosed having hemoglobinopathy of specified variety. 3 of these 10 participants of \u201cmalaria-never\u201d group had low G6PD levels also.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Malaria Protection Hypothesis was not found to be true as per our findings, but there were subtle hints that G6PD protection with or without change in hemoglobin alteration maybe operable.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_947_20","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T08:45:28Z","timestamp":1606725928000},"page":"5638-5645","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of protective relationship of G6PD and other lifestyle factors with Malaria: A case-control study of medical professionals from a teaching medical institute, Gujarat"],"prefix":"10.4103","volume":"9","author":[{"given":"Niraj","family":"Pandit","sequence":"first","affiliation":[{"name":"Prof and Head, Department of Community Medicine, SBKS Medical Institute and Research Centre and Dhiraj Hospital, Sumandeep Deemed University, Piparia, (Dist :Vadodara) Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejaskumar","family":"Kalaria","sequence":"additional","affiliation":[{"name":"Ex. Assistant Professor in Biochemistry, SBKS Medical Institute and Research Centre and Dhiraj Hospital, Sumandeep Deemed University, Piparia, (Dist :Vadodara) Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitendra D.","family":"Lakhani","sequence":"additional","affiliation":[{"name":"Professor of Medicine and Academic Director, SBKS Medical Institute and Research Centre and Dhiraj Hospital, Sumandeep Deemed University, Piparia, (Dist :Vadodara) Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmin","family":"Jasani","sequence":"additional","affiliation":[{"name":"Professor of Pathology and Incharge Central Laboratory, SBKS Medical Institute and Research Centre and Dhiraj Hospital, Sumandeep Deemed University, Piparia, (Dist :Vadodara) Gujarat, 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