{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:35:15Z","timestamp":1786988115798,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To evaluate salivary ferritin levels in children with severe early childhood caries (ECC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>One hundred twenty participants were split into a study group that consisted of 60 children with severe ECC (dmft \u22655) and a control group that was free of caries. Both groups were age and gender-matched. Saliva was collected from both groups. Salivary ferritin was assessed using chemiluminescence microparticle immunoassay. The data obtained were statistically analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Salivary ferritin levels were higher in children with severe ECC (159.53 \u00b1 18.65 \u03bcg\/dl) compared to children with no caries (92.16 \u00b1 12.91 \u03bcg\/dl) and a highly significant statistical difference was seen (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Salivary ferritin levels were high with children having severe ECC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jfmpc.jfmpc_9_20","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T05:57:47Z","timestamp":1598939867000},"page":"3991-3993","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":12,"title":["Association of severe early childhood caries with salivary ferritin"],"prefix":"10.4103","volume":"9","author":[{"given":"Jagadish","family":"Rajkumaar","sequence":"first","affiliation":[{"name":"Department of Pedodontics and Preventive Dentistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mebin George","family":"Mathew","sequence":"additional","affiliation":[{"name":"Department of Pedodontics and Preventive Dentistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,8]]},"reference":[{"key":"R1-20260817","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/jphd.12299","article-title":"Association of food insecurity with early childhood caries","volume":"79","author":"Angelopoulou","year":"2019","journal-title":"J Public Health Dent"},{"key":"R2-20260817","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/ipd.12490","article-title":"Early childhood caries: IAPD Bangkok declaration","volume":"29","year":"2019","journal-title":"Int J Paediatr Dent"},{"key":"R3-20260817","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1159\/000492790","volume":"53","author":"Nakayama","year":"2019","journal-title":"Caries Res"},{"key":"R4-20260817","first-page":"9","article-title":"Salivary proteins and microbiota as biomarkers for early childhood caries risk assessment","volume":"10","author":"Hemadi","year":"2017","journal-title":"Int J Oral Sci"},{"key":"R5-20260817","doi-asserted-by":"crossref","first-page":"25","DOI":"10.17796\/jcpd.37.1.ap20543762015370","article-title":"Salivary ferritin as a predictive marker of iron deficiency anemia in children","volume":"37","author":"Jagannathan","year":"2012","journal-title":"J Clin Pediatr Dent"},{"key":"R6-20260817","doi-asserted-by":"crossref","first-page":"106","DOI":"10.4103\/JISPPD.JISPPD_71_16","article-title":"Evaluation and association of serum iron and ferritin levels in children with dental caries","volume":"35","author":"Venkatesh Babu","year":"2017","journal-title":"J Indian Soc Pedod Prev Dent"},{"key":"R7-20260817","first-page":"126","article-title":"Relationship between early childhood caries and anemia: A systematic review","volume":"8","author":"Hashemi","year":"2018","journal-title":"Iran J Ped Hematol Oncol"},{"key":"R8-20260817","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0140-6736(15)60865-0","article-title":"Iron deficiency anaemia","volume":"387","author":"Lopez","year":"2016","journal-title":"Lancet"},{"key":"R9-20260817","first-page":"294","article-title":"Is there an association between early childhood caries and serum iron and serum ferritin levels?","volume":"9","author":"Sadeghi","year":"2012","journal-title":"Dent Res J"},{"key":"R10-20260817","first-page":"254","article-title":"Malnourishment in a population of young children with severe early childhood caries","volume":"28","author":"Clarke","year":"2006","journal-title":"Pediatr Dent"},{"key":"R11-20260817","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1471-2431-13-22","article-title":"Association between iron status, iron deficiency anaemia, and severe early childhood caries: A case-control study","volume":"13","author":"Schroth","year":"2013","journal-title":"BMC Pediatr"},{"key":"R12-20260817","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1371\/journal.ppat.1000217","article-title":"The hyphal-associated adhesion and invasion of Candida albicans mediates iron acquisition from host ferritin","volume":"4","author":"Almeida","year":"2008","journal-title":"PLoS Pathog"},{"key":"R13-20260817","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/infdis\/131.1.44","article-title":"Mouth lesions in iron deficiency anemia relationship to Candida albicans in saliva and to impairment of lymphocyte transformation","volume":"131","author":"Fletcher Mather","year":"1975","journal-title":"J Infect Dis"},{"key":"R14-20260817","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3389\/fcimb.2018.00185","article-title":"Iron at the centre of Candida albicans interactions","volume":"8","author":"Fourie","year":"2018","journal-title":"Front Cell Infect Microbiol"},{"key":"R15-20260817","doi-asserted-by":"crossref","first-page":"e970","DOI":"10.1002\/mbo3.970","article-title":"The adaptive responseto iron involves changes in energetic strategies in the pathogen Candida albicans","volume":"9","author":"Duval","year":"2020","journal-title":"Microbiologyopen"},{"key":"R16-20260817","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1159\/000481833","article-title":"Candida albicans and early childhood caries: A systematic review and meta-analysis","volume":"52","author":"Xiao","year":"2018","journal-title":"Caries Res"},{"key":"R17-20260817","doi-asserted-by":"crossref","first-page":"1724484","DOI":"10.1080\/20002297.2020.1724484","article-title":"Candida biome of severe early childhood caries (S-ECC) and its cariogenic virulence traits","volume":"12","author":"Fakhruddin","year":"2020","journal-title":"J Oral Microbiol"},{"key":"R18-20260817","doi-asserted-by":"crossref","DOI":"10.1007\/s00784-020-03204-9","article-title":"Evaluation of adhesion of Streptococcus mutans, plaque accumulation on zirconia and stainless steel crowns, and surrounding gingival inflammation in primary molars: Randomized controlled trial","author":"Mathew","year":"2020","journal-title":"Clin Oral Invest"},{"key":"R19-20260817","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4103\/0970-4388.175508","article-title":"Association of severe early childhood caries with iron deficiency anemia","volume":"34","author":"Bansal","year":"2016","journal-title":"J Indian Soc Pedod Prev Dent"},{"key":"R20-20260817","first-page":"1","article-title":"Iron deficiency in young children: A risk marker for early childhood caries","volume":"6","author":"Koppal","year":"2013","journal-title":"Int J Clin Pediatr Dent"}],"container-title":["Journal of Family Medicine and Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_9_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:02:17Z","timestamp":1786986137000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jfmpc.jfmpc_9_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":20,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_9_20","relation":{},"ISSN":["2249-4863","2278-7135"],"issn-type":[{"value":"2249-4863","type":"print"},{"value":"2278-7135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"2020-01-02","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-03","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}