{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:33:27Z","timestamp":1787841207945,"version":"build-2784847793"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>The splenic tuberculous involvement is common than other intra-abdominal solid organs such as the liver, pancreas, and kidney. The aim of this article is to present and share a review of the English-language literature on splenic tuberculosis (TB) to gain a better understanding of etiopathogenesis, epidemiological features, and diagnostic methods and provide guidelines for its management and to present our experience of six cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The systematic search of the literature was performed on PubMed and Medline from 1950 to 2019 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Fifty-two manuscripts were included in this systematic review. All resulting titles, abstract, and full text, whenever available, were read and kept for reference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Direct histopathological demonstration is the best diagnostic modality. Fine-needle aspiration cytology is the study of choice and polymerase chain reaction assay increases its sensitivity. The standard short course antitubercular therapy for 6 months is recommended for isolated splenic TB, and for widespread disease, 12-month therapy is recommended. Surgery is reserved for failure of medical therapy and complications such as abscess formation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jgid.jgid_102_25","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:00:27Z","timestamp":1774684827000},"page":"10-18","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiological Features, Etiopathogenesis, Diagnostic Evaluation, and Management Protocol of Splenic Tuberculosis: A Systematic Review"],"prefix":"10.4103","volume":"18","author":[{"given":"Poras","family":"Chaudhary","sequence":"first","affiliation":[{"name":"Department of General Surgery, ABVIMS and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of General Surgery, ABVIMS and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milind","family":"Alokjee","sequence":"additional","affiliation":[{"name":"Department of General Surgery, ABVIMS and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhinav","family":"Bhalla","sequence":"additional","affiliation":[{"name":"Department of General Surgery, ABVIMS and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunny","family":"Thakur","sequence":"additional","affiliation":[{"name":"Department of General Surgery, ABVIMS and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanshu","family":"Das","sequence":"additional","affiliation":[{"name":"Department of General Surgery, ABVIMS and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"R1-20260330","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1001\/archinte.1912.00060180042004","article-title":"Tuberculosis of the spleen","volume":"9","author":"Winternitz","year":"1912","journal-title":"Arch Int Med"},{"key":"R2-20260330","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/00000441-193801000-00006","article-title":"A study of tuberculous splenomegaly and splenogenic control of the cell emission from bone marrow","volume":"195","author":"Englebreth-Holm","year":"1938","journal-title":"Am J Med Sci"},{"key":"R3-20260330","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1182\/blood.V4.12.1367.1367","article-title":"Tuberculous splenomegaly with the hypersplenism syndrome; 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