{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:31:17Z","timestamp":1786728677018,"version":"build-2736575974"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome of immune dysregulation that results in multiorgan failure; HIV and histoplasmosis are known triggers of HLH. A young patient with AIDS was found to have disseminated histoplasmosis and met criteria for HLH. Despite 10 days of treatment with liposomal amphotericin B, she developed shock and acute respiratory distress syndrome and ultimately died. The few reported cases of HLH due to histoplasmosis in AIDS offer a variety of treatment approaches. There have been successful outcomes combining amphotericin with chemotherapies for HLH. Targeted therapies for HLH may be considered on a case-by-case basis in the setting of concurrent disseminated histoplasmosis and HIV\/AIDS.<\/jats:p>","DOI":"10.4103\/jgid.jgid_150_24","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T05:00:30Z","timestamp":1740373230000},"page":"63-65","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Hemophagocytic Lymphohistiocytosis Due to Disseminated Histoplasmosis in a Young Patient with AIDS"],"prefix":"10.4103","volume":"17","author":[{"given":"Zachary","family":"Mostel","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, Elmhurst Hospital Center, NYC Health and Hospitals, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Speed","family":"Rogers","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, Elmhurst Hospital Center, NYC Health and Hospitals, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushrita","family":"Neogi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, Elmhurst Hospital Center, NYC Health and Hospitals, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"R1-20250331","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s11046-020-00431-2","article-title":"Re-drawing the maps for endemic mycoses","volume":"185","author":"Ashraf","year":"2020","journal-title":"Mycopathologia"},{"key":"R2-20250331","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1093\/mmy\/myaa112","article-title":"A comparison of presentations and outcomes of histoplasmosis across patients with varying immune status","volume":"59","author":"Franklin","year":"2021","journal-title":"Medical Mycology"},{"key":"R3-20250331","doi-asserted-by":"crossref","first-page":"432","DOI":"10.7861\/clinmedicine.16-5-432","article-title":"Haemophagocytic lymphohistiocytosis: An elusive syndrome","volume":"16","author":"Thomas","year":"2016","journal-title":"Clin Med (Lond)"},{"key":"R4-20250331","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/pbc.21039","article-title":"HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis","volume":"48","author":"Henter","year":"2007","journal-title":"Pediatr Blood Cancer"},{"key":"R5-20250331","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1002\/art.38690","article-title":"Development and validation of the H Score, a score for the diagnosis of reactive hemophagocytic syndrome","volume":"66","author":"Fardet","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"R6-20250331","doi-asserted-by":"crossref","first-page":"ofac071","DOI":"10.1093\/ofid\/ofac071","article-title":"A review of hemophagocytic lymphohistiocytosis in patients with HIV","volume":"9","author":"Tabaja","year":"2022","journal-title":"Open Forum Infect Dis"},{"key":"R7-20250331","doi-asserted-by":"crossref","first-page":"7107326","DOI":"10.1155\/2019\/7107326","article-title":"Histoplasmosis-associated hemophagocytic lymphohistiocytosis: A review of the literature","volume":"2019","author":"Jabr","year":"2019","journal-title":"Can J Infect Dis Med Microbiol"},{"key":"R8-20250331","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.riam.2019.09.002","article-title":"Disseminated histoplasmosis and haemophagocytic syndrome in HIV patients: A case series in a Peruvian hospital","volume":"37","author":"Montenegro-Idrogo","year":"2020","journal-title":"Rev Iberoam Micol"},{"key":"R9-20250331","first-page":"102","article-title":"Hemophagocytic lymphohistiocytosis (HLH) caused by disseminated histoplasmosis by H capsulatum var","volume":"39","author":"Castej\u00f3n-Hern\u00e1ndez","year":"2021","journal-title":"duboisii in HIV patient: A case report. 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