{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:17:34Z","timestamp":1787761054564,"version":"build-2784847793"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Cryptococcosis is a serious systemic mycosis. Its incidence has escalated in the past four decades.\n                      <jats:italic toggle=\"yes\">Cryptococcus neoformans<\/jats:italic>\n                      causes localized or disseminated infection in immunocompromised and immunocompetent patients. The capsulated form is commonly encountered which can be diagnosed on an India ink preparation or antigen detection. However, the noncapsulated forms are very rare and require a high index of suspicion for correct diagnosis. Herein, we present a case of cryptococcal meningitis due to a noncapsulated strain in an apparently immunocompetent patient with no proven immunodeficiencies along with review of world literature. Such cases are a diagnostic challenge for the clinician as well as microbiologist.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jgid.jgid_255_21","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T06:30:55Z","timestamp":1670308255000},"page":"165-169","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Capsule-Deficient Cryptococcal Meningitis"],"prefix":"10.4103","volume":"14","author":[{"given":"Trupti","family":"Shende","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gagandeep","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Immaculata","family":"Xess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Khullar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renu Kumari","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reshu","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Vasantha Padma","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-8-20240828","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/qjmed\/hcl014","article-title":"Cryptococcosis in apparently immunocompetent patients","volume":"99","author":"Lui","year":"2006","journal-title":"QJM"},{"key":"R2-8-20240828","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1128\/CMR.8.4.515","article-title":"Cryptococcosis in the era of AIDS \u2013 100 years after the discovery of Cryptococcus neoformans","volume":"8","author":"Mitchell","year":"1995","journal-title":"Clin Microbiol Rev"},{"key":"R4-8-20240828","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3389\/fmicb.2011.00181","article-title":"Multiple disguises for the same party: The concepts of morphogenesis and phenotypic variations in Cryptococcus neoformans","volume":"2","author":"Zaragoza","year":"2011","journal-title":"Front Microbiol"},{"key":"R5-8-20240828","first-page":"383","article-title":"Histologic response to capsule-deficient Cryptococcus neoformans","volume":"96","author":"Farmer","year":"1973","journal-title":"Arch Pathol"},{"key":"R6-8-20240828","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/art.1780170617","article-title":"Septic arthritis due to nonencapsulated Cryptococcus neoformans with coexisting sarcoidosis","volume":"17","author":"Levinson","year":"1974","journal-title":"Arthritis Rheum"},{"key":"R7-8-20240828","first-page":"347","article-title":"Cryptococcosis historically resembling histoplasmosis. A light and electron m\u00edcroscop\u00edcal study","volume":"99","author":"Gutierrez","year":"1975","journal-title":"Arch Pathol"},{"key":"R8-8-20240828","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF01102745","article-title":"Pulmonary infection with capsule-deficient Cryptococcus neoformans","volume":"382","author":"Harding","year":"1979","journal-title":"Virchows Arch A Pathol Anat Histol"},{"key":"R9-8-20240828","first-page":"49","article-title":"Capsule deficient Cryptococcus neoformans an unusual clinical presentation","volume":"31","author":"Attal","year":"1983","journal-title":"J Assoc Physicians India"},{"key":"R10-8-20240828","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0140-6736(85)90488-X","article-title":"Capsule-deficient cryptococci in AIDS","volume":"326","author":"Bottone","year":"1985","journal-title":"Lancet"},{"key":"R11-8-20240828","first-page":"400","article-title":"Capsule-deficient Cryptococcus neoformans in AIDS patients","volume":"1","author":"Mackenzie","year":"1985","journal-title":"Lancet"},{"key":"R12-8-20240828","first-page":"53","article-title":"Advantage of Fontana-Masson stain in capsule-deficient cryptococcal infection","volume":"111","author":"Ro","year":"1987","journal-title":"Arch Pathol Lab Med"},{"key":"R13-8-20240828","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.11150\/kansenshogakuzasshi1970.63.1206","article-title":"A case of sepsis and meningitis due to capsule-deficient Cryptococcus neoformans with SIADH","volume":"63","author":"Mukae","year":"1989","journal-title":"Kansenshogaku Zasshi"},{"key":"R14-8-20240828","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0022-5347(17)39965-2","article-title":"Granulomatous prostatitis induced by capsule-deficient cryptococcal infection","volume":"143","author":"Milchgrub","year":"1990","journal-title":"J Urol"},{"key":"R15-8-20240828","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1590\/S0004-282X1993000300019","article-title":"Neurocryptococcosis caused by nonencapsulated Cryptococcus neoformans","volume":"51","author":"Lacaz","year":"1993","journal-title":"Arq Neuropsiquiatr"},{"key":"R16-8-20240828","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1023\/A:1006890413901","article-title":"Pulmonary cryptococcosis due to a capsule-deficient strain confused with metastatic lung cancer","volume":"140","author":"Kimura","year":"1997","journal-title":"Mycopathologia"},{"key":"R17-8-20240828","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0163-4453(98)94567-4","article-title":"Microscopy and latex antigen negative cryptococcal meningitis","volume":"36","author":"Laurenson","year":"1998","journal-title":"J Infect"},{"key":"R18-8-20240828","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1136\/jnnp.2004.052662","article-title":"Difficulty in diagnosing chronic meningitis caused by capsule-deficient Cryptococcus neoformans","volume":"76","author":"Sugiura","year":"2005","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R19-8-20240828","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1439-0507.2004.01068.x","article-title":"Proven pulmonary cryptococcosis due to capsule-deficient Cryptococcus neoformans does not differ clinically from proven pulmonary cryptococcosis due to capsule-intact Cr. neoformans","volume":"48","author":"Torres","year":"2005","journal-title":"Mycoses"},{"key":"R20-8-20240828","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3904\/kjim.2006.21.1.83","article-title":"A case of pulmonary cryptococcosis by capsule-deficient Cryptococcus neoformans","volume":"21","author":"Cheon","year":"2006","journal-title":"Korean J Intern Med"},{"key":"R21-8-20240828","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1159\/000325499","article-title":"Capsule-deficient meningeal cryptococcosis","volume":"52","author":"Kanazawa","year":"2008","journal-title":"Acta Cytol"},{"key":"R22-8-20240828","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1590\/S0037-86822008000100015","article-title":"Histopathological techniques for diagnosing cryptococcosis due to capsule-deficient Cryptococcus: Case report","volume":"41","author":"Gazzoni","year":"2008","journal-title":"Rev Soc Bras Med Trop"},{"key":"R23-8-20240828","first-page":"937","article-title":"A case of pulmonary cryptococcosis caused by capsule-deficient Cryptococcus neoformans in an immunocompetent patient","volume":"55","author":"Bavishi","year":"2010","journal-title":"Respir Care"},{"key":"R24-8-20240828","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1590\/S0036-46652010000300006","article-title":"Unusual morphologies of Cryptococcus spp. in tissue specimens: Report of 10 cases","volume":"52","author":"Gazzoni","year":"2010","journal-title":"Rev Inst Med Trop S\u00e3o Paulo"},{"key":"R25-8-20240828","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1177\/1066896910373923","article-title":"Pediatric renal cryptococcosis: Novel manifestations in the acquired immunodeficiency syndrome era","volume":"19","author":"Ramdial","year":"2011","journal-title":"Int J Surg Pathol"},{"key":"R26-8-20240828","doi-asserted-by":"crossref","first-page":"e22","DOI":"10.4081\/cp.2012.e22","article-title":"Treatment of indolent, nonencapsulated cryptococcal meningitis associated with hydrocephalus","volume":"2","author":"Garber","year":"2012","journal-title":"Clin Pract"},{"key":"R27-8-20240828","first-page":"E26","article-title":"Primary capsule-deficient cutaneous cryptococcosis in a sporotrichoid pattern in an immunocompetent host","volume":"96","author":"Herring","year":"2015","journal-title":"Cutis"},{"key":"R30-8-20240828","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/tropicalmed4010001","article-title":"Cryptococcus neoformans: Diagnostic dilemmas, electron microscopy and capsular variants","volume":"4","author":"Birkhead","year":"2018","journal-title":"Trop Med Infect Dis"}],"container-title":["Journal of Global Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jgid.jgid_255_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:17:51Z","timestamp":1787757471000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jgid.jgid_255_21"}},"subtitle":["A Diagnostic Conundrum"],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/jgid.jgid_255_21","relation":{},"ISSN":["0974-777X"],"issn-type":[{"value":"0974-777X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]}}}