{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:32:09Z","timestamp":1787776329292,"version":"build-2784847793"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,1]]},"abstract":"\n Background:<\/jats:title>\n \n Curcuma longa<\/jats:italic>\n has strong anti-inflammatory effect. This study aims to evaluated the level of anti-Toxoplasma immunoglobulin G and immunoglobulin M (IgG-IgM) antibody after intervention with\n C. longa<\/jats:italic>\n extract in early pregnant mice with acute toxoplasmosis.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n We evaluated 20 early pregnant mice that were divided into five groups, four mice in each. Group 1-4 received injections of\n Toxoplasma gondii<\/jats:italic>\n tachyzoites. Three days later, G1 and G2 were given orally 125 mg\/kg\/day and 500 mg\/kg\/day of\n C. longa<\/jats:italic>\n extract, respectively. G3 was given 60 mg\/kg\/day of spiramycin (positive control), and G4 was given 0.2 ml of distilled water (negative control). G5 underwent no intervention at all. Blood samples were obtained serially (before and 3 days after injection of tachyzoites, 3 days and 7 days after intervention) to assess anti-Toxoplasma IgG-IgM antibody levels by enzyme-linked immunosorbent assay methods.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Anti-Toxoplasma IgG-IgM antibody levels increased significantly 3 days after injection of tachyzoites (\n P<\/jats:italic>\n < 0.05), but decreased significantly (\n P<\/jats:italic>\n < 0.05) 3 days, and 7 days after administration of\n C. longa<\/jats:italic>\n extract dose 125 mg, 500 mg, and spiramycin 60 mg, and there was no significant difference between these three groups. Anti-Toxoplasma IgG-IgM antibody levels increased significantly (\n P<\/jats:italic>\n < 0.05) 3 days, 6 days, and 10 days after injections of tachyzoites on G4. The IgG-IgM antibody levels fluctuated on G5 and considered as insignificant (\n P<\/jats:italic>\n > 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n The administration of\n C. longa<\/jats:italic>\n extract at a dose of 125 mg\/kg\/day for 7 days effectively decreased anti-Toxoplasma IgG-IgM antibody level in early pregnant mice with acute toxoplasmosis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jgid.jgid_28_18","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T04:07:57Z","timestamp":1549512477000},"page":"25-29","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Analysis of Anti-toxoplasma Immunoglobulin G and Immunoglobulin M Antibody Levels after Intervention with Curcuma Longa Extract on Early Pregnant Mice with Acute Toxoplasmosis"],"prefix":"10.4103","volume":"11","author":[{"given":"Tigor Peniel","family":"Simanjuntak","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Christian University of Indonesia, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mochammad","family":"Hatta","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Molecular Biology and Immunology Laboratory and Faculty of Medicine, Hasanuddin University, Makassar,, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andi M.","family":"Tahir","sequence":"additional","affiliation":[{"name":"Department of Obstetric and Gynecology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Sirait","sequence":"additional","affiliation":[{"name":"Department of Anaestesiology, Faculty of Medicine, Christian University of Indonesia, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marni B.","family":"Karo","sequence":"additional","affiliation":[{"name":"Midwife Program of Medistra Health Higher School, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Titus","family":"Tambaib","sequence":"additional","affiliation":[{"name":"Midwife Program of Yaleka-Maro School, Merauke, Papua, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ressy","family":"Dwiyanti","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Molecular Biology and Immunology Laboratory and Faculty of Medicine, Hasanuddin University, Makassar,, Indonesia"},{"name":"Department of Medical Microbiology, Faculty of Medicine, Tadulako University, Palu, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rizki Amelia","family":"Noviyanthi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Molecular Biology and Immunology Laboratory and Faculty of Medicine, Hasanuddin University, Makassar,, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ade Rifka","family":"Junita","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Molecular Biology and Immunology Laboratory and Faculty of Medicine, Hasanuddin University, Makassar,, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250523","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/S0020-7519(00)00124-7","article-title":"Toxoplasma gondii: From animals to humans","volume":"30","author":"Tenter","year":"2000","journal-title":"Int J Parasitol"},{"key":"R3-20250523","doi-asserted-by":"crossref","first-page":"143","DOI":"10.4103\/0255-0857.62492","article-title":"Serological screening for antenatal toxoplasma infection in India","volume":"28","author":"Khurana","year":"2010","journal-title":"Indian J Med 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