{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:34:49Z","timestamp":1792722889162,"version":"4.5.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Candida auris<\/jats:italic>\n                      has turned up as a multidrug-resistant nosocomial agent with outbreaks reported worldwide. The present study was conducted to evaluate the antifungal drug susceptibility pattern of\n                      <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Isolates of\n                      <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n                      were obtained from clinically suspected cases of candidemia from January 2019 to June 2021. Identification was done with matrix-assisted laser desorption\/ionization-time of flight (MALDI-TOF) and panfungal DNA polymerase chain reaction (PCR), followed by sequencing. Antifungal susceptibility testing was performed with broth microdilution method.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Out of 50 isolates\n                      <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n                      , 49 were identified by MALDI-TOF and one isolate was identified with panfungal DNA PCR followed by sequencing. For fluconazole, 84% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 42) isolates were found to be resistant and 16% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 8) isolates were susceptible (minimum inhibitory concentrations [MICs] range 0.5\u201316). Posaconazole exhibited potent activity, followed by itraconazole. For amphotericin B, only 6% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 3) isolates were resistant with MICs \u22652 \u03bcg\/mL. Only 4% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 2) isolates exhibited resistance to caspofungin. No resistance was noted for micafungin and anidulafungin. One (2%) isolate was found to be panazole resistant. One (2%) isolate was resistant to fluconazole, amphotericin B, and caspofungin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Correct identification of\n                      <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n                      can be obtained with the use of MALDI-TOF and sequencing methods. A small percentage of fluconazole-sensitive isolates are present. Although elevated MICs for amphotericin B and echinocandins are not generally observed, the possibility of resistance with the irrational use of these antifungal drugs cannot be denied. Pan azole-resistant and pan drug-resistant strains of\n                      <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n                      are on rise.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jgid.jgid_44_22","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T02:41:53Z","timestamp":1667270513000},"page":"131-135","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":15,"title":["Identification and Antifungal Drug Susceptibility Pattern of Candida auris in India"],"prefix":"10.4103","volume":"14","author":[{"given":"Smita","family":"Deshkar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niranjan","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shraddha","family":"Amberkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Lad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farozan","family":"Siddiqui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Sharan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-2-20240828","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1056\/NEJMra1315399","article-title":"Invasive candidiasis","volume":"373","author":"Kullberg","year":"2015","journal-title":"N Engl J Med"},{"key":"R2-2-20240828","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s40560-018-0342-4","article-title":"Epidemiology, clinical characteristics, resistance, and treatment of infections by Candida auris","volume":"6","author":"Cortegiani","year":"2018","journal-title":"J Intensive Care"},{"key":"R3-2-20240828","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1080\/21505594.2021.1928410","article-title":"A biological and genomic comparison of a drug-resistant and a drug-susceptible strain of Candida auris isolated from Beijing, China","volume":"12","author":"Fan","year":"2021","journal-title":"Virulence"},{"key":"R4-2-20240828","doi-asserted-by":"crossref","first-page":"e00458","DOI":"10.1128\/mSphere.00458-19","article-title":"Combined antifungal resistance and biofilm tolerance: The global threat of Candida auris","volume":"4","author":"Kean","year":"2019","journal-title":"mSphere"},{"key":"R5-2-20240828","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.3390\/microorganisms9102177","article-title":"What do we know about Candida auris? 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