{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:27:26Z","timestamp":1791671246191,"version":"4.3.4"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>Here, we present a case of severe meningoencephalitis caused by combined infection with tick-borne encephalitis (TBE) and Lyme borreliosis (LB) in a 25-year-old woman in a rural area of Zhambyl region, Kazakhstan. She presented with fever, nausea, vomiting, weakness, sweating, severe headache, arthralgia, and malaise. The course of illness was further complicated by encephalitis with symmetric lesions of the midbrain cerebral peduncles and serous meningitis. TBE and LB co-infection were established by a two-fold increase in serum IgG titers between day 21 and day 25 of illness. Both infections responded well to combined therapy with human TBE immunoglobulins, antibiotics, antiviral drugs, glucocorticoids, and diuretics. The outcome of the disease was favorable and the patient recovered completely.<\/jats:p>","DOI":"10.4103\/jgid.jgid_76_22","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T18:41:35Z","timestamp":1683744095000},"page":"81-83","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["A Case of Combined Infection with Tick-Borne Encephalitis and Lyme Borreliosis with Severe Meningoencephalitis and Complete Recovery"],"prefix":"10.4103","volume":"15","author":[{"given":"Yekaterina O.","family":"Ostapchuk","sequence":"first","affiliation":[{"name":"Almaty Branch of the National Center for Biotechnology, Almaty, Kazakhstan"},{"name":"Laboratory of Molecular Immunology and Immunobiotechnology, M.A. Aitkhozhin\u2019s Institute of Molecular Biology and Biochemistry, Almaty, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey M.","family":"Dmitrovskiy","sequence":"additional","affiliation":[{"name":"Almaty Branch of the National Center for Biotechnology, Almaty, Kazakhstan"},{"name":"National Scientific Center for Especially Dangerous Infections, Almaty, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena A.","family":"Pak","sequence":"additional","affiliation":[{"name":"Taraz City Multidisciplinary Hospital, Taraz, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliya V.","family":"Perfilyeva","sequence":"additional","affiliation":[{"name":"Almaty Branch of the National Center for Biotechnology, Almaty, Kazakhstan"},{"name":"Laboratory of Molecular Immunology and Immunobiotechnology, M.A. Aitkhozhin\u2019s Institute of Molecular Biology and Biochemistry, Almaty, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,3,31]]},"reference":[{"key":"R1-20240828","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1863-2378.2011.01435.x","article-title":"Following a tick bite:Double infections by tick-borne encephalitis virus and the spirochete Borrelia and other potential multiple infections","volume":"59","author":"Br\u00f6ker","year":"2012","journal-title":"Zoonoses Public Health"},{"key":"R2-20240828","first-page":"25","article-title":"Clinical characteristics of tick-borne encephalitis in mixed infection with Lyme borrelliosis","volume":"45","author":"Amosov","year":"2000","journal-title":"Vopr Virusol"},{"key":"R3-20240828","first-page":"26","article-title":"Combination therapy for the focal form of mixed tick-borne encephalitis and borreliosis infection","volume":"8","author":"Etenko","year":"2016","journal-title":"Neurol Neuropsychiatr Psychosom"},{"key":"R5-20240828","doi-asserted-by":"crossref","first-page":"119","DOI":"10.5604\/17331331.1197285","article-title":"IgG avidity:An important serologic marker for the diagnosis of tick-borne encephalitis virus infection","volume":"65","author":"Vilibic-Cavlek","year":"2016","journal-title":"Pol J Microbiol"},{"key":"R7-20240828","first-page":"Doc03","article-title":"Guidelines for diagnosis and treatment in neurology \u2013Lyme neuroborreliosis","volume":"18","author":"Rauer","year":"2020","journal-title":"Ger Med Sci"},{"key":"R8-20240828","doi-asserted-by":"crossref","first-page":"101498","DOI":"10.1016\/j.ttbdis.2020.101498","article-title":"Tick-borne pathogens and their vectors in Kazakhstan \u2013A review","volume":"11","author":"Perfilyeva","year":"2020","journal-title":"Ticks Tick Borne Dis"},{"key":"R10-20240828","first-page":"353","article-title":"Russian preparation of human immunoglobulin for urgent prophylaxis and treatment of tick-borne encephalitis","volume":"36","author":"Olefir","year":"2015","journal-title":"Immunologiya"}],"container-title":["Journal of Global Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jgid.jgid_76_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:07:15Z","timestamp":1787760435000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jgid.jgid_76_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,31]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/jgid.jgid_76_22","relation":{},"ISSN":["0974-777X","0974-8245"],"issn-type":[{"value":"0974-777X","type":"print"},{"value":"0974-8245","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,31]]},"assertion":[{"value":"2022-04-19","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-13","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}