{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:09:52Z","timestamp":1790647792728,"version":"4.1.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Contacts of tuberculosis (TB) patients have an increased risk of latent TB infection (LTBI). Currently, it is diagnosed using one of the two methods: Tuberculin skin test (TST) or QuantiFERON-TB Gold Plus. This study aims to estimate the concordance of TST and QFT-TB Gold Plus and associated factors among 73 healthcare workers (HCWs) and 172 household contacts (HHCs) who came in contact with active TB patients. This study was conducted from January to June 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Prevalence and agreement were calculated. A regression analysis was performed to assess the predictors of discordance factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The prevalence of latent TB was 20.40% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 50), defined as a positive result on either test. The overall agreement among participants was 62.04%, with a kappa coefficient of 0.26 (0.16\u20130.36, 95% confidence interval [CI]) (McNemar,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). A higher risk of LTBI was associated with BCG vaccination history, odd ratio 1.63, (95% CI 0.78\u20133.43) for TST and 0.51 (95% CI 0.22\u20131.15) for QFT, but this was not significant. Moreover, in our study, only the body mass index of 18.5\u201325 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      yielded an odds ratio of 2.33 (95%CI 0.77\u20136.47) for TST and 1.72 (95% CI 0.48\u20136.05) for QFT, was significant. Compared with QFT-TB Gold Plus, the sensitivity and specificity of TST were 80.65 (68.63\u201389.58) and 55.74 (48.22\u201363.06).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>TST exhibited a profound level of agreement with the QFT-Gold Plus assay but showed a higher rate of positivity due to some associated factors among HCWs, HHCs, and TB patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jgid.jgid_78_24","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T04:18:39Z","timestamp":1743394719000},"page":"52-59","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Latent Tuberculosis Infection among Household Contacts of Tuberculosis Patients, Healthcare Workers, and Tuberculosis Patients Using QuantiFERON-tuberculosis Gold Plus and Tuberculin Skin Test in a Tertiary Care Hospital Setting Bhubaneswar, Odisha \u2013 A Cross-sectional Study"],"prefix":"10.4103","volume":"17","author":[{"given":"Braja Sundar","family":"Barik","sequence":"first","affiliation":[{"name":"Division of NCDs, ICMR-Regional Medical Research Centre, Bhubaneswar, Odisha, India"},{"name":"Department of Biotechnology, School of Biotechnology, KIIT University, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinmay Divyadarshi","family":"Kar","sequence":"additional","affiliation":[{"name":"Division of NCDs, ICMR-Regional Medical Research Centre, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shritam","family":"Das","sequence":"additional","affiliation":[{"name":"Division of NCDs, ICMR-Regional Medical Research Centre, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahziba","family":"Hussain","sequence":"additional","affiliation":[{"name":"Division of NCDs, ICMR-Regional Medical Research Centre, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasmita","family":"Nayak","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Biotechnology, KIIT University, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun Kumar","family":"Sahu","sequence":"additional","affiliation":[{"name":"Department of TB and Chest Diseases, Capital Hospital, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sooman","family":"Sundaray","sequence":"additional","affiliation":[{"name":"Department of TB and Chest Diseases, Capital Hospital, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanghamitra","family":"Pati","sequence":"additional","affiliation":[{"name":"Division of NCDs, ICMR-Regional Medical Research Centre, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,3,31]]},"reference":[{"key":"R1-20250331","first-page":"1","year":"2023","journal-title":"WHO"},{"key":"R2-20250331","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4103\/ijmr.ijmr_382_23","article-title":"The prevalence of tuberculosis infection in India: A systematic review and meta-analysis","volume":"157","author":"Chauhan","year":"2023","journal-title":"Indian J Med Res"},{"key":"R3-20250331","doi-asserted-by":"crossref","first-page":"201","DOI":"10.4046\/trd.2016.79.4.201","article-title":"Tuberculosis infection and latent tuberculosis","volume":"79","author":"Lee","year":"2016","journal-title":"Tuberc Respir Dis 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