{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:27:50Z","timestamp":1787772470966,"version":"build-2784847793"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>In addition to the well-known toxicities of treatment, survivors of pediatric solid tumors can also develop other health-related conditions. They may either be an indirect consequence of therapy or could be unrelated to their prior history of malignancy. We aim to evaluate the nontoxicity related health conditions in survivors of pediatric solid tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The study included a cohort of hepatoblastoma (HB), Wilm's tumor (WT), and malignant germ cell tumors (MGCT) survivors registered at pediatric surgical-oncology clinic from 1994 to 2016. Follow-up was done according to standard protocols and children were evaluated at each visit for any health-related conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the survivors, 318 survivors, comprising of 48, 81, and 189 survivors of HB, MGCT, and WT, respectively, were included in the analysis. We found 20.8% of patients with HB, 11.1% of patients with MGCT, and 16.4% of patients with WT to report nontoxicity-related health issues. A high prevalence of surgical conditions (3.4%), secondary malignancies (1.2%), gynecological conditions in girls (16.9%), tuberculosis (1.2%), gallstone disease (0.9%), pelvi-ureteral junction obstruction (0.9%), and neurological issues (0.9%) was noted. Two presumed survivors had died, one due to a late recurrence and the other due to a secondary malignancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>A high prevalence of medically or surgically manageable conditions makes it imperative to keep these children under follow-up to address any health-related conditions they may subsequently develop.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jiaps.jiaps_104_23","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T10:25:50Z","timestamp":1716546350000},"page":"472-478","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Looking Beyond Toxicities"],"prefix":"10.4103","volume":"28","author":[{"given":"Mehak","family":"Sehgal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishesh","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Agarwala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjan","family":"Dhua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabudh","family":"Goel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devendra Kumar","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Bakhshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mani","family":"Kalaivani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-5-20240905","doi-asserted-by":"crossref","first-page":"264","DOI":"10.4103\/0019-509X.55546","article-title":"Epidemiology of childhood cancer in India","volume":"46","author":"Arora","year":"2009","journal-title":"Indian J Cancer"},{"key":"R2-5-20240905","doi-asserted-by":"crossref","first-page":"e28556","DOI":"10.1002\/pbc.28556","article-title":"Childhood cancer survivorship and late effects: The landscape in India in 2020","volume":"67","author":"Arora","year":"2020","journal-title":"Pediatr Blood Cancer"},{"key":"R3-5-20240905","doi-asserted-by":"crossref","first-page":"e2200044","DOI":"10.1200\/GO.22.00044","article-title":"Long-term outcomes in survivors of childhood cancer: A 30-year experience from India","volume":"8","author":"Prasad","year":"2022","journal-title":"JCO Glob Oncol"},{"key":"R4-5-20240905","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/cncr.33981","article-title":"Chronic comorbid conditions among adult cancer survivors in the United States: Results from the national health interview survey, 2002-2018","volume":"128","author":"Jiang","year":"2022","journal-title":"Cancer"},{"key":"R5-5-20240905","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1056\/NEJMsa060185","article-title":"Chronic health conditions in adult survivors of childhood cancer","volume":"355","author":"Oeffinger","year":"2006","journal-title":"N Engl J Med"},{"key":"R7-5-20240905","doi-asserted-by":"crossref","first-page":"e29030","DOI":"10.1002\/pbc.29030","article-title":"Cumulative burden of chronic health conditions among adolescent and young adult survivors of childhood cancer: Identification of vulnerable groups at key medical transitions","volume":"68","author":"Ehrhardt","year":"2021","journal-title":"Pediatr Blood Cancer"},{"key":"R8-5-20240905","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1200\/JCO.2015.61.5070","article-title":"Intestinal obstruction in survivors of childhood cancer: A report from the childhood cancer survivor study","volume":"33","author":"Madenci","year":"2015","journal-title":"J Clin Oncol"},{"key":"R9-5-20240905","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1097\/00000658-199321850-00011","article-title":"Small bowel obstruction after nephrectomy for Wilms' tumor. 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